PLD6;

Mitochondrial cardiolipin hydrolase;

Mitochondrial phospholipase(MitoPLD);Choline phosphatase 6;Phospholipase D6(PLD 6);Phosphatidylcholine-hydrolyzing phospholipase D6;

Bovine (Bos taurus). 

Homodimer.

Cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

Mitochondrion outer membrane Single-pass membrane protein

220

N/A

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bta:526651

PF13091

Bt.88339