PPP1CA ELISA Kit for Human(Homo sapiens) | EIAab.comPPP1CA ELISA Kit for Human(Homo sapiens)

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PPP1CA (Gene name),

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Protein name ), PP1A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PPP1CA(PPP1A);

Protein name:

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit(PP-1A);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with SH3RF2 (By similarity). Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with HHV-1 ICP34.5. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site. Interacts with isoform 1 and isoform 4 of NEK2.

Function:

Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.

Subcellular Location:

Cytoplasm Nucleus Nucleus nucleoplasm Nucleus nucleolus Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.

Protein Attributes:

Sequence length:

330

Sequence:

50:

100:

150:

200:

250:

300:

330:

KNKGKYGQFS | GLNPGGRPIT | PPRNSAKAKK |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.183994

STRING:

9606.ENSP00000326031

String:

P62136

MIM:

176875

Pfam:

PF00149

SMR:

P62136

KEGG:

hsa:5499

Uniprot:

P62136

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ELISA Kit for Human PP-1A

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E9568h

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ELISA Kit for Human PP-1A

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ELISA Kit for Human PP-1A

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ELISA Kit for Human PP-1A

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E9568m

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96T

ELISA Kit for Human PP-1A

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E9568r

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96T

ELISA Kit for Human PP-1A

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CLIA Kit for Human PP-1A

Cat.:

U9568b

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96T

CLIA Kit for Human PP-1A

MSDS:

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CLIA Kit for Human PP-1A

Cat.:

U9568h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human PP-1A

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CLIA Kit for Human PP-1A

Cat.:

U9568m

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Packing:

96T

CLIA Kit for Human PP-1A

Cat.:

U9568r

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96T

Polyclonal Antibody for Human PP-1A

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P9568Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human PP-1A

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P9568Rb-m

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Polyclonal Antibody for Human PP-1A

Monoclonal Antibody for Human PP-1A

Protein for Human PP-1A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of a human protein phosphatase 1-encoding cDNA."
Song Q. , Khanna K.K. , Lu H. , Lavin M.F.
Gene129:291-295(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Lung.
2.

"The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit."
Durfee T. , Becherer K. , Chen P.L. , Yeh S.H. , Yang Y. , Kilburn A.E. , Lee W.H. , Elledge S.J.
Genes Dev.7:555-569(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.

Tung L.
Submitted (1991-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Synovial cell.
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Muscle.
tissue: Pancreas.
tissue: Placenta.
8.

Bienvenut W.V. , Heiserich L. , Gottlieb E.
Submitted (2008-10) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-15 AND 247-261;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Colon carcinoma.
9.

"Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13."
Barker H.M. , Jones T.A. , da Cruz e Silva E.F. , Spurr N.K. , Sheer D. , Cohen P.T.W.
Genomics7:159-166(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-330 (ISOFORM 1)
10.

"The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase."
He B. , Gross M. , Roizman B.
Proc. Natl. Acad. Sci. U.S.A.94:843-848(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R15A AND HHV-1 ICP34.5
11.

"Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells."
Trinkle-Mulcahy L. , Sleeman J.E. , Lamond A.I.
J. Cell Sci.114:4219-4228(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PPP1R8
12.

"Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1."
Connor J.H. , Weiser D.C. , Li S. , Hallenbeck J.M. , Shenolikar S.
Mol. Cell. Biol.21:6841-6850(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R15A
13.

"Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1."
Ceulemans H. , Vulsteke V. , De Maeyer M. , Tatchell K. , Stalmans W. , Bollen M.
J. Biol. Chem.277:47331-47337(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R7
14.

"Protein phosphatase 1 -- targeted in many directions."
Cohen P.T.W.
J. Cell Sci.115:241-256(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
15.

"The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation."
Kim K. , Li L. , Kozlowski K. , Suh H.S. , Cao W. , Ballermann B.J.
Biochem. Biophys. Res. Commun.338:1327-1334(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R16B AND RPSA
16.

"A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress."
Boyce M. , Bryant K.F. , Jousse C. , Long K. , Harding H.P. , Scheuner D. , Kaufman R.J. , Ma D. , Coen D.M. , Ron D. , Yuan J.
Science307:935-939(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
17.

"Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells."
Pasder O. , Shpungin S. , Salem Y. , Makovsky A. , Vilchick S. , Michaeli S. , Malovani H. , Nir U.
Oncogene25:4194-4206(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FER;PHOSPHORYLATION AT THR-320
18.

"The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G."
Ulke-Lemee A. , Trinkle-Mulcahy L. , Chaulk S. , Bernstein N.K. , Morrice N. , Glover M. , Lamond A.I. , Moorhead G.B.G.
Biochim. Biophys. Acta1774:1339-1350(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH ILF2; ILF3; YLPM1; KHDRBS1; RBMX AND NCOA5;INTERACTION WITH YLPM1
19.

"Protein phosphatase-1alpha regulates centrosome splitting through Nek2."
Mi J. , Guo C. , Brautigan D.L. , Larner J.M.
Cancer Res.67:1082-1089(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NEK2;DEPHOSPHORYLATION
20.

"Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase."
Wu W. , Baxter J.E. , Wattam S.L. , Hayward D.G. , Fardilha M. , Knebel A. , Ford E.M. , da Cruz e Silva E.F. , Fry A.M.
J. Biol. Chem.282:26431-26440(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEK2
21.

"NOM1 targets protein phosphatase I to the nucleolus."
Gunawardena S.R. , Ruis B.L. , Meyer J.A. , Kapoor M. , Conklin K.F.
J. Biol. Chem.283:398-404(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH NOM1
22.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-320;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
23.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-320;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
24.

"GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis."
Fujiki R. , Chikanishi T. , Hashiba W. , Ito H. , Takada I. , Roeder R.G. , Kitagawa H. , Kato S.
Nature459:455-459(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MLL5-L COMPLEX
25.

"Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions."
Jiang Y. , Luo W. , Howe P.H.
Oncogene28:2999-3007(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
26.

"Identification and characterization of a novel human PP1 phosphatase complex."
Lee J.H. , You J. , Dobrota E. , Skalnik D.G.
J. Biol. Chem.285:24466-24476(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE PTW/PP1 PHOSPHATASE COMPLEX;INTERACTION WITH WDR82; PPP1R8 AND PPP1R10/PNUTS
27.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-320;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
28.

"SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1."
Li X. , Lin H.H. , Chen H. , Xu X. , Shih H.M. , Ann D.K.
Sci. Signal.3:RA32-RA32(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM28
29.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
30.

"Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock."
Schmutz I. , Wendt S. , Schnell A. , Kramer A. , Mansuy I.M. , Albrecht U.
PLoS ONE6:E21325-E21325(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN CLOCK
31.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
32.

"Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors."
Kelker M.S. , Page R. , Peti W.
J. Mol. Biol.385:11-21(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 7-300 IN COMPLEX WITH INHIBITORS;COFACTOR;MANGANESE-BINDING SITES;SUBUNIT
33.

"Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites."
Ragusa M.J. , Dancheck B. , Critton D.A. , Nairn A.C. , Page R. , Peti W.
Nat. Struct. Mol. Biol.17:459-464(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 7-330 IN COMPLEX WITH RAT PPP1R9A AND PPP1R9B

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