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Index > Protein center > Ppp2ca(Gene name) > Mouse
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  • Ppp2ca (Gene name),
  • Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (Protein name ),  PP2AA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ppp2ca;
    Protein name:
    Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform(PP2A-alpha);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct. Interacts with TP53, SGOL1 and SGOL2. Interacts with AXIN1; the interaction dephosphorylates AXIN1(By similarity). Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3.
    Function:
    PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I.
    Subcellular Location:
    Cytoplasm Nucleus Chromosome centromere Cytoplasm cytoskeleton spindle pole In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). Centromeric localization requires the presence of SGOL2.
    Protein Attributes:
    Sequence length:
    309
    Sequence:
    50:
    MDEKLFTKEL | DQWIEQLNEC | KQLSESQVKS | LCEKAKEILT | KESNVQEVRC | 
    100:
    PVTVCGDVHG | QFHDLMELFR | IGGKSPDTNY | LFMGDYVDRG | YYSVETVTLL | 
    150:
    VALKVRYRER | ITILRGNHES | RQITQVYGFY | DECLRKYGNA | NVWKYFTDLF | 
    200:
    DYLPLTALVD | GQIFCLHGGL | SPSIDTLDHI | RALDRLQEVP | HEGPMCDLLW | 
    250:
    SDPDDRGGWG | ISPRGAGYTF | GQDISETFNH | ANGLTLVSRA | HQLVMEGYNW | 
    300:
    CHDRNVVTIF | SAPNYCYRCG | NQAAIMELDD | TLKYSFLQFD | PAPRRGEPHV | 
    309:
    TRRTPDYFL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse PP2A-alpha
    ELISA Kit for Mouse PP2A-alpha
    ELISA Kit for Mouse PP2A-alpha
    ELISA Kit for Mouse PP2A-alpha
    ELISA Kit for Mouse PP2A-alpha
    ELISA Kit for Mouse PP2A-alpha
    ELISA Kit for Mouse PP2A-alpha
    CLIA Kit for Mouse PP2A-alpha
    CLIA Kit for Mouse PP2A-alpha
    CLIA Kit for Mouse PP2A-alpha
    CLIA Kit for Mouse PP2A-alpha
    CLIA Kit for Mouse PP2A-alpha
    CLIA Kit for Mouse PP2A-alpha
    CLIA Kit for Mouse PP2A-alpha
    Polyclonal Antibody for Mouse PP2A-alpha
    Polyclonal Antibody for Mouse PP2A-alpha
    Polyclonal Antibody for Mouse PP2A-alpha
    Polyclonal Antibody for Mouse PP2A-alpha
    Polyclonal Antibody for Mouse PP2A-alpha
    Polyclonal Antibody for Mouse PP2A-alpha
    Polyclonal Antibody for Mouse PP2A-alpha
    Monoclonal Antibody for Mouse PP2A-alpha
    Monoclonal Antibody for Mouse PP2A-alpha
    Monoclonal Antibody for Mouse PP2A-alpha
    Monoclonal Antibody for Mouse PP2A-alpha
    Monoclonal Antibody for Mouse PP2A-alpha
    Monoclonal Antibody for Mouse PP2A-alpha
    Monoclonal Antibody for Mouse PP2A-alpha
    Protein for Mouse PP2A-alpha
    Protein for Mouse PP2A-alpha
    Protein for Mouse PP2A-alpha
    Protein for Mouse PP2A-alpha
    Protein for Mouse PP2A-alpha
    Protein for Mouse PP2A-alpha
    Protein for Mouse PP2A-alpha

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    References
    1. 1.
      Goetz J.M. , Kues W.
      Submitted (1996-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6 X DBA/2.
      tissue: Brain.
    2. 2.
      "Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain."
      Hsu W. , Zeng L. , Costantini F.
      J. Biol. Chem.274:3439-3445(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Spleen.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Eye.
      tissue: Mammary gland.
    6. 6.
      "Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts."
      Chen J. , Parsons S. , Brautigan D.L.
      J. Biol. Chem.269:7957-7962(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-307
    7. 7.
      "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2."
      Chung H. , Nairn A.C. , Murata K. , Brautigan D.L.
      Biochemistry38:10371-10376(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-307 AND LEU-309;METHYLATION AT LEU-309
    8. 8.
      "Interaction of nucleoredoxin with protein phosphatase 2A."
      Lechward K. , Sugajska E. , de Baere I. , Goris J. , Hemmings B.A. , Zolnierowicz S.
      FEBS Lett.580:3631-3637(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NXN
    9. 9.
      "A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB."
      Nawa M. , Kanekura K. , Hashimoto Y. , Aiso S. , Matsuoka M.
      Cell. Signal.20:493-505(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BTBD10
    10. 10.
      "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells."
      Lee J. , Kitajima T.S. , Tanno Y. , Yoshida K. , Morita T. , Miyano T. , Miyake M. , Watanabe Y.
      Nat. Cell Biol.10:42-52(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    11. 11.
      "KCTD20, a relative of BTBD10, is a positive regulator of Akt."
      Nawa M. , Matsuoka M.
      BMC Biochem.14:27-27(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCTD20
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