Protein name:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct. Interacts with TP53, SGOL1 and SGOL2. Interacts with AXIN1; the interaction dephosphorylates AXIN1(By similarity). Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3.
Function:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I.
Subcellular Location:
Cytoplasm
Nucleus
Chromosome
centromere
Cytoplasm
cytoskeleton
spindle pole
In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). Centromeric localization requires the presence of SGOL2.
Protein Attributes:
50:
MDEKLFTKEL | DQWIEQLNEC | KQLSESQVKS | LCEKAKEILT | KESNVQEVRC |
100:
PVTVCGDVHG | QFHDLMELFR | IGGKSPDTNY | LFMGDYVDRG | YYSVETVTLL |
150:
VALKVRYRER | ITILRGNHES | RQITQVYGFY | DECLRKYGNA | NVWKYFTDLF |
200:
DYLPLTALVD | GQIFCLHGGL | SPSIDTLDHI | RALDRLQEVP | HEGPMCDLLW |
250:
SDPDDRGGWG | ISPRGAGYTF | GQDISETFNH | ANGLTLVSRA | HQLVMEGYNW |
300:
CHDRNVVTIF | SAPNYCYRCG | NQAAIMELDD | TLKYSFLQFD | PAPRRGEPHV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Human
Mouse
Pig
Bovine
Rabbit
Rat
ELISA Kit for Mouse PP2A-alpha
ELISA Kit for Mouse PP2A-alpha
ELISA Kit for Mouse PP2A-alpha
ELISA Kit for Mouse PP2A-alpha
ELISA Kit for Mouse PP2A-alpha
ELISA Kit for Mouse PP2A-alpha
ELISA Kit for Mouse PP2A-alpha
CLIA Kit for Mouse PP2A-alpha
CLIA Kit for Mouse PP2A-alpha
CLIA Kit for Mouse PP2A-alpha
CLIA Kit for Mouse PP2A-alpha
CLIA Kit for Mouse PP2A-alpha
CLIA Kit for Mouse PP2A-alpha
CLIA Kit for Mouse PP2A-alpha
Polyclonal Antibody for Mouse PP2A-alpha
Polyclonal Antibody for Mouse PP2A-alpha
Polyclonal Antibody for Mouse PP2A-alpha
Polyclonal Antibody for Mouse PP2A-alpha
Polyclonal Antibody for Mouse PP2A-alpha
Polyclonal Antibody for Mouse PP2A-alpha
Polyclonal Antibody for Mouse PP2A-alpha
Monoclonal Antibody for Mouse PP2A-alpha
Monoclonal Antibody for Mouse PP2A-alpha
Monoclonal Antibody for Mouse PP2A-alpha
Monoclonal Antibody for Mouse PP2A-alpha
Monoclonal Antibody for Mouse PP2A-alpha
Monoclonal Antibody for Mouse PP2A-alpha
Monoclonal Antibody for Mouse PP2A-alpha
Protein for Mouse PP2A-alpha
Protein for Mouse PP2A-alpha
Protein for Mouse PP2A-alpha
Protein for Mouse PP2A-alpha
Protein for Mouse PP2A-alpha
Protein for Mouse PP2A-alpha
Protein for Mouse PP2A-alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6 X DBA/2 .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
NOD .
tissue :
Spleen .
4.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
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more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Eye .
tissue :
Mammary gland .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-307
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF TYR-307 AND LEU-309;METHYLATION AT LEU-309
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NXN
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BTBD10
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH KCTD20