Protein name:
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) ;
Alternative:
Nuclear receptor subfamily 1 group C member 3 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with FAM120B. Interacts with PRDM16 (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with TGFB1I1. Interacts with DNTTIP2. Interacts with PRMT2.
Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MGETLGDSPI | DPESDSFTDT | LSANISQEMT | MVDTEMPFWP | TNFGISSVDL |
100:
SVMEDHSHSF | DIKPFTTVDF | SSISTPHYED | IPFTRTDPVV | ADYKYDLKLQ |
150:
EYQSAIKVEP | ASPPYYSEKT | QLYNKPHEEP | SNSLMAIECR | VCGDKASGFH |
200:
YGVHACEGCK | GFFRRTIRLK | LIYDRCDLNC | RIHKKSRNKC | QYCRFQKCLA |
250:
VGMSHNAIRF | GRMPQAEKEK | LLAEISSDID | QLNPESADLR | ALAKHLYDSY |
300:
IKSFPLTKAK | ARAILTGKTT | DKSPFVIYDM | NSLMMGEDKI | KFKHITPLQE |
350:
QSKEVAIRIF | QGCQFRSVEA | VQEITEYAKS | IPGFVNLDLN | DQVTLLKYGV |
400:
HEIIYTMLAS | LMNKDGVLIS | EGQGFMTREF | LKSLRKPFGD | FMEPKFEFAV |
450:
KFNALELDDS | DLAIFIAVII | LSGDRPGLLN | VKPIEDIQDN | LLQALELQLK |
500:
LNHPESSQLF | AKLLQKMTDL | RQIVTEHVQL | LQVIKKTETD | MSLHPLLQEI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Dog
Pig
Mouse
Rabbit
ELISA Kit for Human PPAR-gamma
ELISA Kit for Human PPAR-gamma
ELISA Kit for Human PPAR-gamma
ELISA Kit for Human PPAR-gamma
ELISA Kit for Human PPAR-gamma
ELISA Kit for Human PPAR-gamma
ELISA Kit for Human PPAR-gamma
CLIA Kit for Human PPAR-gamma
CLIA Kit for Human PPAR-gamma
CLIA Kit for Human PPAR-gamma
CLIA Kit for Human PPAR-gamma
CLIA Kit for Human PPAR-gamma
CLIA Kit for Human PPAR-gamma
CLIA Kit for Human PPAR-gamma
Polyclonal Antibody for Human PPAR-gamma
Polyclonal Antibody for Human PPAR-gamma
Polyclonal Antibody for Human PPAR-gamma
Polyclonal Antibody for Human PPAR-gamma
Polyclonal Antibody for Human PPAR-gamma
Polyclonal Antibody for Human PPAR-gamma
Polyclonal Antibody for Human PPAR-gamma
Monoclonal Antibody for Human PPAR-gamma
Monoclonal Antibody for Human PPAR-gamma
Monoclonal Antibody for Human PPAR-gamma
Monoclonal Antibody for Human PPAR-gamma
Monoclonal Antibody for Human PPAR-gamma
Monoclonal Antibody for Human PPAR-gamma
Monoclonal Antibody for Human PPAR-gamma
Protein for Human PPAR-gamma
Protein for Human PPAR-gamma
Protein for Human PPAR-gamma
Protein for Human PPAR-gamma
Protein for Human PPAR-gamma
Protein for Human PPAR-gamma
Protein for Human PPAR-gamma
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;TISSUE SPECIFICITY
tissue :
Heart .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue :
Adipose tissue .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Adipose tissue .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO 36; 37; 213; 214 AND 240
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
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Placenta .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Placenta .
8.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
9.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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"Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility."
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Submitted (2008-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-12
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"The DNA sequence, annotation and analysis of human chromosome 3."
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
15.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
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Cited for : INTERACTION WITH NCOA6
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO GLIOMA
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PRMT2
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NOCA7
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DNTTIP2
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TGFB1I1
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HELZ2
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PDPK1;ENZYME REGULATION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MAP2K1/MEK1;SUBCELLULAR LOCATION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ASXL1 AND ASXL2
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH HELZ2 AND THRAP3;SUBCELLULAR LOCATION
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 232-505
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 235-504 IN COMPLEXES WITH THE SYNTHETIC AGONIST ROSIGLITAZONE AND NCOA1;SUBUNIT
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEXES WITH RXRA AND SYNTHETIC AGONISTS
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 234-505 IN COMPLEXES WITH SYNTHETIC AGONIST AND NCOA1
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 225-505 IN COMPLEX WITH SYNTHETIC AGONIST
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 230-505 IN COMPLEX WITH SYNTHETIC AGONIST
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 232-505 IN COMPLEX WITH NCOA2 AND SYNTHETIC AGONIST
35.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 235-505 IN COMPLEX WITH RXRA; NCOA1 AND SYNTHETIC AGONIST
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 231-505 IN COMPLEX WITH SYNTHETIC AGONIST
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 234-505 IN COMPLEX WITH SYNTHETIC AGONIST AND NR0B2
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"Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 234-505 IN COMPLEX WITH SYNTHETIC AGONIST AND NCOA1
39.
"Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) OF 235-505 IN COMPLEX WITH SYNTHETIC AGONIST
40.
"Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities."
Lu I.-L.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS) OF 235-505 IN COMPLEX WITH SYNTHETIC AGONIST
41.
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Cited for : VARIANT ALA-12
42.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT OBESITY GLN-113
43.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION OF VARIANT ALA-12 WITH BMI
44.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ALA-12
45.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION OF VARIANT ALA-12 WITH BMI
46.
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Cited for : VARIANTS COLON CANCER PRO-314 AND HIS-316;VARIANT ALA-12
47.
"Dominant negative mutations in human PPAR-gamma associated with severe insulin resistance, diabetes mellitus and hypertension."
Barroso I.
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Nature402:880-883(1999)
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Cited for : VARIANTS DIABETES MET-318 AND LEU-495
48.
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Cited for : VARIANT FPLD3 LEU-388
49.
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Cited for : VARIANT FPLD3 CYS-425
50.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION OF VARIANT ALA-12 WITH BMI
51.
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Cited for : ASSOCIATION OF VARIANT ALA-12 WITH CIMT
52.
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Cited for : VARIANT ALA-12