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Index > Protein center > PPARG(Gene name) > Human
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  • PPARG (Gene name),
  • Peroxisome proliferator-activated receptor gamma (Protein name ),  PPARG_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PPARG(NR1C3);
    Protein name:
    Peroxisome proliferator-activated receptor gamma(PPAR-gamma);
    Alternative:
    Nuclear receptor subfamily 1 group C member 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with FAM120B. Interacts with PRDM16 (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with TGFB1I1. Interacts with DNTTIP2. Interacts with PRMT2.
    Function:
    Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    505
    Sequence:
    50:
    MGETLGDSPI | DPESDSFTDT | LSANISQEMT | MVDTEMPFWP | TNFGISSVDL | 
    100:
    SVMEDHSHSF | DIKPFTTVDF | SSISTPHYED | IPFTRTDPVV | ADYKYDLKLQ | 
    150:
    EYQSAIKVEP | ASPPYYSEKT | QLYNKPHEEP | SNSLMAIECR | VCGDKASGFH | 
    200:
    YGVHACEGCK | GFFRRTIRLK | LIYDRCDLNC | RIHKKSRNKC | QYCRFQKCLA | 
    250:
    VGMSHNAIRF | GRMPQAEKEK | LLAEISSDID | QLNPESADLR | ALAKHLYDSY | 
    300:
    IKSFPLTKAK | ARAILTGKTT | DKSPFVIYDM | NSLMMGEDKI | KFKHITPLQE | 
    350:
    QSKEVAIRIF | QGCQFRSVEA | VQEITEYAKS | IPGFVNLDLN | DQVTLLKYGV | 
    400:
    HEIIYTMLAS | LMNKDGVLIS | EGQGFMTREF | LKSLRKPFGD | FMEPKFEFAV | 
    450:
    KFNALELDDS | DLAIFIAVII | LSGDRPGLLN | VKPIEDIQDN | LLQALELQLK | 
    500:
    LNHPESSQLF | AKLLQKMTDL | RQIVTEHVQL | LQVIKKTETD | MSLHPLLQEI | 
    505:
    YKDLY
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human PPAR-gamma
    Cat.:
    E0886h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PPAR-gamma
    Cat.:
    E0886r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PPAR-gamma
    Cat.:
    E0886b
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    MSDS:
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    96T
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    ELISA Kit for Human PPAR-gamma
    Cat.:
    E0886d
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    96T
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    ELISA Kit for Human PPAR-gamma
    Cat.:
    E0886p
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    MSDS:
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    96T
    Range:
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    ELISA Kit for Human PPAR-gamma
    Cat.:
    E0886m
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human PPAR-gamma
    MSDS:
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    CLIA Kit for Human PPAR-gamma
    Cat.:
    U0886r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PPAR-gamma
    Cat.:
    U0886p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PPAR-gamma
    MSDS:
    Please sign in first.
    CLIA Kit for Human PPAR-gamma
    Cat.:
    U0886h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PPAR-gamma
    Cat.:
    U0886m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PPAR-gamma
    Cat.:
    U0886d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PPAR-gamma
    Cat.:
    U0886b
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PPAR-gamma
    Polyclonal Antibody for Human PPAR-gamma
    Polyclonal Antibody for Human PPAR-gamma
    Polyclonal Antibody for Human PPAR-gamma
    Cat.:
    P0886Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PPAR-gamma
    Cat.:
    P0886Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PPAR-gamma
    Polyclonal Antibody for Human PPAR-gamma
    Cat.:
    P0886Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PPAR-gamma
    Monoclonal Antibody for Human PPAR-gamma
    Monoclonal Antibody for Human PPAR-gamma
    Monoclonal Antibody for Human PPAR-gamma
    Monoclonal Antibody for Human PPAR-gamma
    Monoclonal Antibody for Human PPAR-gamma
    Monoclonal Antibody for Human PPAR-gamma
    Protein for Human PPAR-gamma
    Protein for Human PPAR-gamma
    Protein for Human PPAR-gamma
    Protein for Human PPAR-gamma
    Protein for Human PPAR-gamma
    Protein for Human PPAR-gamma
    Protein for Human PPAR-gamma

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    Precision
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    Recovery
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    Linearity
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    L

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    References
    1. 1.
      "Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists."
      Mukherjee R. , Jow L. , Croston G.E. , Paterniti J.R. Jr.
      J. Biol. Chem.272:8071-8076(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;TISSUE SPECIFICITY
      tissue: Heart.
    2. 2.
      "Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2."
      Elbrecht A. , Chen Y. , Cullinan C.A. , Hayes N. , Leibowitz M.D. , Moller D.E. , Berger J.
      Biochem. Biophys. Res. Commun.224:431-437(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Adipose tissue.
    3. 3.
      "Differential expression of PPAR gamma1 and gamma2 isoforms in human adipose tissue."
      Yanase T. , Yashiro T. , Takitani K. , Kato S. , Taniguchi S. , Takayanagi R. , Nawata H.
      Biochem. Biophys. Res. Commun.233:320-324(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Adipose tissue.
    4. 4.
      "Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping."
      Greene M.E. , Blumberg B. , McBride O.W. , Yi H.F. , Kronquist K. , Kwan K. , Hsieh L. , Greene G. , Nimer S.D.
      Gene Expr.4:281-299(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Bone marrow.
    5. 5.
      Greene M.E.
      Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 36; 37; 213; 214 AND 240
    6. 6.
      "No coding mutations are detected in the peroxisome proliferator-activated receptor-gamma gene in Japanese patients with lipoatrophic diabetes."
      Okazawa H. , Mori H. , Tamori Y. , Araki S. , Niki T. , Masugi J. , Kawanishi M. , Kubota T. , Shinoda H. , Kasuga M.
      Diabetes46:1904-1906(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
      tissue: Placenta.
    7. 7.
      "A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs."
      Lambe K.G. , Tugwood J.D.
      Eur. J. Biochem.239:1-7(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    8. 8.
      "Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity."
      Kim H.J. , Woo I.S. , Kang E.S. , Eun S.Y. , Kim H.J. , Lee J.H. , Chang K.C. , Kim J.H. , Seo H.G.
      Biochem. Biophys. Res. Commun.347:698-706(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    10. 10.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    11. 11.
      "Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility."
      Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
      Submitted (2008-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    12. 12.
      SeattleSNPs variation discovery resource
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-12
    13. 13.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    15. 15.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    16. 16.
      "Cloning and characterization of RAP250, a nuclear receptor coactivator."
      Caira F. , Antonson P. , Pelto-Huikko M. , Treuter E. , Gustafsson J.-A.
      J. Biol. Chem.275:5308-5317(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
    17. 17.
      "Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population."
      Zhou X.P. , Smith W.M. , Gimm O. , Mueller E. , Gao X. , Sarraf P. , Prior T.W. , Plass C. , von Deimling A. , Black P.M. , Yates A.J. , Eng C.
      J. Med. Genet.37:410-414(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO GLIOMA
    18. 18.
      "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."
      Qi C. , Chang J. , Zhu Y. , Yeldandi A.V. , Rao S.M. , Zhu Y.-J.
      J. Biol. Chem.277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRMT2
    19. 19.
      "ERAP140, a conserved tissue-specific nuclear receptor coactivator."
      Shao W. , Halachmi S. , Brown M.
      Mol. Cell. Biol.22:3358-3372(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOCA7
    20. 20.
      "ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."
      Bu H. , Kashireddy P. , Chang J. , Zhu Y.T. , Zhang Z. , Zheng W. , Rao S.M. , Zhu Y.-J.
      Biochem. Biophys. Res. Commun.317:54-59(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNTTIP2
    21. 21.
      "Hic-5 regulates an epithelial program mediated by PPARgamma."
      Drori S. , Girnun G.D. , Tou L. , Szwaya J.D. , Mueller E. , Xia K. , Shivdasani R.A. , Spiegelman B.M.
      Genes Dev.19:362-375(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
    22. 22.
      "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the DNA-binding domain of peroxisome proliferator-activated receptor gamma."
      Tomaru T. , Satoh T. , Yoshino S. , Ishizuka T. , Hashimoto K. , Monden T. , Yamada M. , Mori M.
      Endocrinology147:377-388(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HELZ2
    23. 23.
      "3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation."
      Yin Y. , Yuan H. , Wang C. , Pattabiraman N. , Rao M. , Pestell R.G. , Glazer R.I.
      Mol. Endocrinol.20:268-278(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PDPK1;ENZYME REGULATION
    24. 24.
      "Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma."
      Burgermeister E. , Chuderland D. , Hanoch T. , Meyer M. , Liscovitch M. , Seger R.
      Mol. Cell. Biol.27:803-817(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP2K1/MEK1;SUBCELLULAR LOCATION
    25. 25.
      "Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma."
      Park S.H. , Choi H.J. , Yang H. , Do K.H. , Kim J. , Lee D.W. , Moon Y.
      J. Biol. Chem.285:35330-35339(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    26. 26.
      "Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}."
      Park U.H. , Yoon S.K. , Park T. , Kim E.J. , Um S.J.
      J. Biol. Chem.286:1354-1363(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASXL1 AND ASXL2
    27. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HELZ2 AND THRAP3;SUBCELLULAR LOCATION
    28. 28.
      "Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma."
      Uppenberg J. , Svensson C. , Jaki M. , Bertilsson G. , Jendeberg L. , Berkenstam A.
      J. Biol. Chem.273:31108-31112(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 232-505
    29. 29.
      "Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma."
      Nolte R.T. , Wisely G.B. , Westin S. , Cobb J.E. , Lambert M.H. , Kurokawa R. , Rosenfeld M.G. , Willson T.M. , Glass C.K. , Milburn M.V.
      Nature395:137-143(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 235-504 IN COMPLEXES WITH THE SYNTHETIC AGONIST ROSIGLITAZONE AND NCOA1;SUBUNIT
    30. 30.
      "Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors."
      Gampe R.T. Jr. , Montana V.G. , Lambert M.H. , Miller A.B. , Bledsoe R.K. , Milburn M.V. , Kliewer S.A. , Willson T.M. , Xu H.E.
      Mol. Cell5:545-555(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEXES WITH RXRA AND SYNTHETIC AGONISTS
    31. 31.
      "Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors."
      Xu H.E. , Lambert M.H. , Montana V.G. , Plunket K.D. , Moore L.B. , Collins J.L. , Oplinger J.A. , Kliewer S.A. , Gampe R.T. Jr. , McKee D.D. , Moore J.T. , Willson T.M.
      Proc. Natl. Acad. Sci. U.S.A.98:13919-13924(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 234-505 IN COMPLEXES WITH SYNTHETIC AGONIST AND NCOA1
    32. 32.
      "Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family."
      Cronet P. , Petersen J.F.W. , Folmer R. , Blomberg N. , Sjoeblom K. , Karlsson U. , Lindstedt E.-L. , Bamberg K.
      Structure9:699-706(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 225-505 IN COMPLEX WITH SYNTHETIC AGONIST
    33. 33.
      "Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar."
      Ebdrup S. , Pettersson I. , Rasmussen H.B. , Deussen H.-J. , Frost Jensen A. , Mortensen S.B. , Fleckner J. , Pridal L. , Nygaard L. , Sauerberg P.
      J. Med. Chem.46:1306-1317(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 230-505 IN COMPLEX WITH SYNTHETIC AGONIST
    34. 34.
      "A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects."
      Oestberg T. , Svensson S. , Selen G. , Uppenberg J. , Thor M. , Sundbom M. , Sydow-Baeckman M. , Gustavsson A.-L. , Jendeberg L.
      J. Biol. Chem.279:41124-41130(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 232-505 IN COMPLEX WITH NCOA2 AND SYNTHETIC AGONIST
    35. 35.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 235-505 IN COMPLEX WITH RXRA; NCOA1 AND SYNTHETIC AGONIST
    36. 36.
      "Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity."
      Shi G.Q. , Dropinski J.F. , McKeever B.M. , Xu S. , Becker J.W. , Berger J.P. , MacNaul K.L. , Elbrecht A. , Zhou G. , Doebber T.W. , Wang P. , Chao Y.-S. , Forrest M. , Heck J.V. , Moller D.E. , Jones A.B.
      J. Med. Chem.48:4457-4468(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 231-505 IN COMPLEX WITH SYNTHETIC AGONIST
    37. 37.
      "Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner."
      Li Y. , Choi M. , Suino K. , Kovach A. , Daugherty J. , Kliewer S.A. , Xu H.E.
      Proc. Natl. Acad. Sci. U.S.A.102:9505-9510(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 234-505 IN COMPLEX WITH SYNTHETIC AGONIST AND NR0B2
    38. 38.
      "Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis."
      Hopkins C.R. , O'neil S.V. , Laufersweiler M.C. , Wang Y. , Pokross M. , Mekel M. , Evdokimov A. , Walter R. , Kontoyianni M. , Petrey M.E. , Sabatakos G. , Roesgen J.T. , Richardson E. , Demuth T.P. Jr.
      Bioorg. Med. Chem. Lett.16:5659-5663(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 234-505 IN COMPLEX WITH SYNTHETIC AGONIST AND NCOA1
    39. 39.
      "Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies."
      Mahindroo N. , Wang C.-C. , Liao C.-C. , Huang C.-F. , Lu I.-L. , Lien T.-W. , Peng Y.-H. , Huang W.-J. , Lin Y.-T. , Hsu M.-C. , Lin C.-H. , Tsai C.-H. , Hsu J.-T. , Chen X. , Lyu P.-C. , Chao Y.-S. , Wu S.-Y. , Hsieh H.-P.
      J. Med. Chem.49:1212-1216(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) OF 235-505 IN COMPLEX WITH SYNTHETIC AGONIST
    40. 40.
      "Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities."
      Lu I.-L. , Huang C.-F. , Peng Y.-H. , Lin Y.-T. , Hsieh H.-P. , Chen C.-T. , Lien T.-W. , Lee H.-J. , Mahindroo N. , Prakash E. , Yueh A. , Chen H.-Y. , Goparaju C.M.V. , Chen X. , Liao C.-C. , Chao Y.-S. , Hsu J.-T. , Wu S.-Y.
      J. Med. Chem.49:2703-2712(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS) OF 235-505 IN COMPLEX WITH SYNTHETIC AGONIST
    41. 41.
      "Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR-gamma) gene in diabetic Caucasians: identification of a pro12ala PPAR-gamma-2 missense mutation."
      Yen C.-J. , Beamer B.A. , Negri C. , Silver K. , Brown K.A. , Yarnall D.P. , Burns D.K. , Roth J. , Shuldiner A.R.
      Biochem. Biophys. Res. Commun.241:270-274(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-12
    42. 42.
      "Obesity associated with a mutation in a genetic regulator of adipocyte differentiation."
      Ristow M. , Muller-Wieland D. , Pfeiffer A. , Krone W. , Kahn C.R.
      N. Engl. J. Med.339:953-959(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OBESITY GLN-113
    43. 43.
      "A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity."
      Deeb S.S. , Fajas L. , Nemoto M. , Pihlajamaeki J. , Mykkaenen L. , Kuusisto J. , Laakso M. , Fujimoto W. , Auwerx J.
      Nat. Genet.20:284-287(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT ALA-12 WITH BMI
    44. 44.
      "Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjects."
      Hamann A. , Munzberg H. , Buttron P. , Busing B. , Hinney A. , Mayer H. , Siegfried W. , Hebebrand J. , Greten H.
      Eur. J. Endocrinol.141:90-92(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-12
    45. 45.
      "Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women."
      Valve R. , Sivenius K. , Miettinen R. , Pihlajamaeki J. , Rissanen A. , Deeb S.S. , Auwerx J. , Uusitupa M. , Laakso M.
      J. Clin. Endocrinol. Metab.84:3708-3712(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT ALA-12 WITH BMI
    46. 46.
      "Loss-of-function mutations in PPAR-gamma associated with human colon cancer."
      Sarraf P. , Mueller E. , Smith W.M. , Wright H.M. , Kum J.B. , Aaltonen L.A. , de la Chapelle A. , Spiegelman B.M. , Eng C.
      Mol. Cell3:799-804(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS COLON CANCER PRO-314 AND HIS-316;VARIANT ALA-12
    47. 47.
      "Dominant negative mutations in human PPAR-gamma associated with severe insulin resistance, diabetes mellitus and hypertension."
      Barroso I. , Gurnell M. , Crowley V.E.F. , Agostini M. , Schwabel J.W. , Soos M.A. , Masien G.L. , Williams T.D.M. , Lewis H. , Schafer A.J. , Chatterjee V.K.K. , O'Rahilly S.
      Nature402:880-883(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DIABETES MET-318 AND LEU-495
    48. 48.
      "PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy."
      Hegele R.A. , Cao H. , Frankowski C. , Mathews S.T. , Leff T.
      Diabetes51:3586-3590(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FPLD3 LEU-388
    49. 49.
      "A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy."
      Agarwal A.K. , Garg A.
      J. Clin. Endocrinol. Metab.87:408-411(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FPLD3 CYS-425
    50. 50.
      "Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis."
      Masud S. , Ye S.
      J. Med. Genet.40:773-780(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT ALA-12 WITH BMI
    51. 51.
      "Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis."
      Temelkova-Kurktschiev T. , Hanefeld M. , Chinetti G. , Zawadzki C. , Haulon S. , Kubaszek A. , Koehler C. , Leonhardt W. , Staels B. , Laakso M.
      J. Clin. Endocrinol. Metab.89:4238-4242(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT ALA-12 WITH CIMT
    52. 52.
      "Effects of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism on body fat distribution in female Korean subjects."
      Kim K.S. , Choi S.M. , Shin S.U. , Yang H.S. , Yoon Y.
      Metabolism53:1538-1543(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-12
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