PRDX2 ELISA Kit for Human(Homo sapiens) | EIAab.comPRDX2 ELISA Kit for Human(Homo sapiens)

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PRDX2 (Gene name),

Peroxiredoxin-2 (Protein name ), PRDX2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (3)

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Gene name:

PRDX2(NKEFB;TDPX1);

Protein name:

Peroxiredoxin-2;

Alternative:

PRP;Natural killer cell-enhancing factor B(NKEF-B);Thioredoxin peroxidase 1;Thiol-specific antioxidant protein(TSA);Thioredoxin-dependent peroxide reductase 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.

Function:

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

198

Sequence:

50:

100:

150:

198:

SVDEALRLVQ | AFQYTDEHGE | VCPAGWKPGS | DTIKPNVDDS | KEYFSKHN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:7001

String:

P32119

Pfam:

PF10417

MIM:

600538

STRING:

9606.ENSP00000301522

SMR:

P32119

UniGene:

Hs.432121

Uniprot:

P32119

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ELISA Kit for Human Peroxiredoxin-2

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E1123h

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96T

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ELISA Kit for Human Peroxiredoxin-2

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E1123r

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96T

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ELISA Kit for Human Peroxiredoxin-2

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E1123b

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96T

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ELISA Kit for Human Peroxiredoxin-2

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E1123m

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ELISA Kit for Human Peroxiredoxin-2

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CLIA Kit for Human Peroxiredoxin-2

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CLIA Kit for Human Peroxiredoxin-2

Cat.:

U1123b

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96T

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CLIA Kit for Human Peroxiredoxin-2

Cat.:

U1123h

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Packing:

96T

CLIA Kit for Human Peroxiredoxin-2

Cat.:

U1123m

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96T

CLIA Kit for Human Peroxiredoxin-2

Cat.:

U1123r

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96T

Polyclonal Antibody for Human Peroxiredoxin-2

Cat.:

P1123Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Peroxiredoxin-2

Cat.:

P1123Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Peroxiredoxin-2

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P1123Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Peroxiredoxin-2

Protein for Human Peroxiredoxin-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Novel links among peroxiredoxins, endothelial dysfunction, and severity of atherosclerosis in type 2 diabetic patients with peripheral atherosclerotic"

E El Eter, A Al Masri, S Habib, H Al Zamil, A AI Hersi, F AI Hussein, M AI Omran

From:Cell Stress and Chaperones

[2].

"Differential associations of circulating peroxiredoxins levels with indicators of glycemic control in type 2 diabetes mellitus"

AA Al-Masri, E El Eter, S Tayel, et al.

From:Eur Rev Med Pharmacol Sci

[3].

"Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus"

E El Eter, AA Al-Masri

From:Brazilian Journal of Medical and Biological Research

References

1.

"The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions."
Lim Y.-S. , Cha M.-K. , Kim H.-K. , Kim I.-H.
Gene140:279-284(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"Cloning and sequence analysis of candidate human natural killer-enhancing factor genes."
Shau H. , Butterfield L.H. , Chiu R. , Kim A.
Immunogenetics40:129-134(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Cerebellum.
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

NIEHS SNPs program
Submitted (2005-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-153
6.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Hypothalamus.
tissue: Lung.
9.

Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 8-26; 67-135 AND 140-150;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
10.

"Thioredoxin-linked peroxidase from human red blood cell: evidence for the existence of thioredoxin and thioredoxin reductase in human red blood cell."
Cha M.-K. , Kim I.-H.
Biochem. Biophys. Res. Commun.217:900-907(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 8-24;CATALYTIC ACTIVITY
tissue: Erythrocyte.
11.

"Plasma and red blood cell protein maps: update 1993."
Golaz O. , Hughes G.J. , Frutiger S. , Paquet N. , Bairoch A. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Appel R.D. , Walzer C. , Balant L. , Hochstrasser D.F.
Electrophoresis14:1223-1231(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-26; 93-103 AND 120-129
tissue: Erythrocyte.
12.

"A two-dimensional gel database of human colon carcinoma proteins."
Ji H. , Reid G.E. , Moritz R.L. , Eddes J.S. , Burgess A.W. , Simpson R.J.
Electrophoresis18:605-613(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-26; 111-135 AND 140-157
tissue: Colon carcinoma.
13.

"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-25; 140-150 AND 163-185
tissue: Keratinocyte.
14.

Oberbaeumer I.
Submitted (1996-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-198 (ISOFORM 1)
15.

"Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site."
Rabilloud T. , Heller M. , Gasnier F. , Luche S. , Rey C. , Aebersold R. , Benahmed M. , Louisot P. , Lunardi J.
J. Biol. Chem.277:19396-19401(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEROXIDATION AT CYS-51
16.

"Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress."
Chevallet M. , Wagner E. , Luche S. , van Dorsselaer A. , Leize-Wagner E. , Rabilloud T.
J. Biol. Chem.278:37146-37153(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RETROREDUCTION OF CYS-51;IDENTIFICATION BY MASS SPECTROMETRY
17.

"Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors."
Gotter A.L. , Suppa C. , Emanuel B.S.
J. Mol. Biol.366:36-52(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIPIN
18.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution."
Schroeder E. , Littlechild J.A. , Lebedev A.A. , Errington N. , Vagin A.A. , Isupov M.N.
Structure8:605-615(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1-198

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