PGR ELISA Kit for Human(Homo sapiens) | EIAab.comPGR ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > PGR(Gene name) > Human

PGR (Gene name),

Progesterone receptor (Protein name ), PRGR_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

PGR(NR3C3);

Protein name:

Progesterone receptor(PR);

Alternative:

Nuclear receptor subfamily 3 group C member 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.

Function:

Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.

Subcellular Location:

Isoform A Nucleus Cytoplasm Mainly nuclear.

Protein Attributes:

Sequence length:

933

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

933:

LSVEFPEMMS | EVIAAQLPKI | LAGMVKPLLF | HKK

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

9606.ENSP00000325120

SMR:

P06401

MIM:

607311

Pfam:

PF00104

KEGG:

hsa:5241

UniGene:

Hs.32405

String:

P06401

Uniprot:

P06401

FOR

ELISA Kit for Human PR

Cat.:

E1273h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human PR

Cat.:

E1273r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human PR

Cat.:

E1273d

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human PR

Cat.:

E1273c

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human PR

Cat.:

E1273m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human PR

MSDS:

Please sign in first.

CLIA Kit for Human PR

Cat.:

U1273m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human PR

Cat.:

U1273d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human PR

Cat.:

U1273c

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human PR

MSDS:

Please sign in first.

CLIA Kit for Human PR

Cat.:

U1273r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human PR

Cat.:

U1273h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human PR

Cat.:

P1273Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human PR

Cat.:

P1273Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human PR

Cat.:

P1273Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human PR

Protein for Human PR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B."
Kastner P. , Krust A. , Turcotte B. , Stropp U. , Tora L. , Gronemeyer H. , Chambon P.
EMBO J.9:1603-1614(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING;VARIANT THR-344
2.

"Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA."
Misrahi M. , Atger M. , D'Auriol L. , Loosfelt H. , Meriel C. , Fridlansky F. , Guiochon-Mantel A. , Galibert F. , Milgrom E.
Biochem. Biophys. Res. Commun.143:740-748(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LEU-660
3.

Kieback D.G. , Agoulnik I.U. , Tong X.-W.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LEU-660
4.

"Progesterone Receptor, alternative splicing variant, mRNA."
Hisatomi H. , Wakita K. , Kohno N. , Nagao K. , Hirata H. , Hikiji K.
Submitted (2002-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
tissue: Mammary tumor.
5.

"The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor."
Chen C. , Opazo J.C. , Erez O. , Uddin M. , Santolaya-Forgas J. , Goodman M. , Grossman L.I. , Romero R. , Wildman D.E.
Mol. Phylogenet. Evol.47:637-649(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Cloning and expression of a novel, truncated, progesterone receptor."
Saner K.J. , Welter B.H. , Zhang F. , Hansen E. , Dupont B. , Wei Y. , Price T.M.
Mol. Cell. Endocrinol.200:155-163(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);VARIANT LEU-660
tissue: Adipose tissue.
tissue: Aorta.
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Uterus.
8.

NIEHS SNPs program
Submitted (2004-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-50; VAL-120; LEU-186; ARG-301; THR-344; SER-444; LEU-529; PRO-536; VAL-651 AND LEU-865
9.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites."
Knotts T.A. , Orkiszewski R.S. , Cook R.G. , Edwards D.P. , Weigel N.L.
J. Biol. Chem.276:8475-8483(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 11-22 AND 673-679;PHOSPHORYLATION AT SER-20; SER-102; SER-130; SER-162; SER-190; SER-213; SER-345 AND SER-676;IDENTIFICATION BY MASS SPECTROMETRY
12.

"A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration."
Dai Q. , Shah A.A. , Garde R.V. , Yonish B.A. , Zhang L. , Medvitz N.A. , Miller S.E. , Hansen E.L. , Dunn C.N. , Price T.M.
Mol. Endocrinol.27:741-753(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 204-217;FUNCTION (ISOFORM 4);SUBCELLULAR LOCATION (ISOFORM 4)
tissue: Heart.
13.

"Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor."
Zhang Y. , Beck C.A. , Poletti A. , Edwards D.P. , Weigel N.L.
Mol. Endocrinol.9:1029-1040(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-81 AND SER-162
14.

"Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system."
Beck C.A. , Zhang Y. , Altmann M. , Weigel N.L. , Edwards D.P.
J. Biol. Chem.271:19546-19555(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-81; SER-102; SER-162; SER-294 AND SER-345
15.

"Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo."
Zhang Y. , Beck C.A. , Poletti A. , Clement J.P. IV , Prendergast P. , Yip T.-T. , Hutchens T.W. , Edwards D.P. , Weigel N.L.
Mol. Endocrinol.11:823-832(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-162; SER-190 AND SER-400
16.

"Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody."
Clemm D.L. , Sherman L. , Boonyaratanakornkit V. , Schrader W.T. , Weigel N.L. , Edwards D.P.
Mol. Endocrinol.14:52-65(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-190 AND SER-294
17.

"Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome."
Lange C.A. , Shen T. , Horwitz K.B.
Proc. Natl. Acad. Sci. U.S.A.97:1032-1037(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-294;UBIQUITINATION;MUTAGENESIS OF SER-294; SER-344 AND SER-345
18.

"Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."
Qi C. , Chang J. , Zhu Y. , Yeldandi A.V. , Rao S.M. , Zhu Y.-J.
J. Biol. Chem.277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRMT2
19.

"BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation."
Hsiao P.W. , Fryer C.J. , Trotter K.W. , Wang W. , Archer T.K.
Mol. Cell. Biol.23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMARD1
20.

"Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2."
Pierson-Mullany L.K. , Lange C.A.
Mol. Cell. Biol.24:10542-10557(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-400;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-400
21.

"Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity."
Narayanan R. , Edwards D.P. , Weigel N.L.
Mol. Cell. Biol.25:2885-2898(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-162; SER-190 AND SER-294;SUBCELLULAR LOCATION;FUNCTION
22.

"GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway."
Chadli A. , Graham J.D. , Abel M.G. , Jackson T.A. , Gordon D.F. , Wood W.M. , Felts S.J. , Horwitz K.B. , Toft D.
Mol. Cell. Biol.26:1722-1730(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UNC45A
23.

"PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus."
Man J.-H. , Li H.-Y. , Zhang P.-J. , Zhou T. , He K. , Pan X. , Liang B. , Li A.-L. , Zhao J. , Gong W.-L. , Jin B.-F. , Xia Q. , Yu M. , Shen B.-F. , Zhang X.-M.
Nucleic Acids Res.34:5552-5566(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-7; LYS-388 AND LYS-531;INTERACTION WITH PIAS3;FUNCTION;MUTAGENESIS OF LYS-7; LYS-388 AND LYS-531
24.

"CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome."
Zhang P.-J. , Zhao J. , Li H.-Y. , Man J.-H. , He K. , Zhou T. , Pan X. , Li A.-L. , Gong W.-L. , Jin B.-F. , Xia Q. , Yu M. , Shen B.-F. , Zhang X.-M.
EMBO J.26:1831-1842(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CUEDC2;SUMOYLATION AT LYS-388;UBIQUITINATION AT LYS-388;FUNCTION;MUTAGENESIS OF LYS-388
25.

"Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells."
Daniel A.R. , Faivre E.J. , Lange C.A.
Mol. Endocrinol.21:2890-2906(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-294;SUMOYLATION AT LYS-388;FUNCTION;MUTAGENESIS OF SER-294 AND LYS-388
26.

"Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth."
Daniel A.R. , Qiu M. , Faivre E.J. , Ostrander J.H. , Skildum A. , Lange C.A.
Steroids72:188-201(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-294;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-294
27.

"Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors."
Faivre E.J. , Daniel A.R. , Hillard C.J. , Lange C.A.
Mol. Endocrinol.22:823-837(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-294; SER-345 AND SER-400;INTERACTION WITH SP1;FUNCTION;MUTAGENESIS OF SER-344; SER-345 AND SER-400
28.

"DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors."
Pedram A. , Razandi M. , Deschenes R.J. , Levin E.R.
Mol. Biol. Cell23:188-199(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION
29.

"Atomic structure of progesterone complexed with its receptor."
Williams S.P. , Sigler P.B.
Nature393:392-396(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 682-933
30.

"Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget."
Zhang Z. , Olland A.M. , Zhu Y. , Cohen J. , Berrodin T. , Chippari S. , Appavu C. , Li S. , Wilhem J. , Chopra R. , Fensome A. , Zhang P. , Wrobel J. , Unwalla R.J. , Lyttle C.R. , Winneker R.C.
J. Biol. Chem.280:28468-28475(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 676-933

Product Feedback Wall

* Email:
*Comments: