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Index > Protein center > PROK1(Gene name) > Human
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  • PROK1 (Gene name),
  • Prokineticin-1 (Protein name ),  PROK1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    PROK1(UNQ600/PRO1186);
    Protein name:
    Prokineticin-1;
    Alternative:
    Mambakine;Endocrine-gland-derived vascular endothelial growth factor(EG-VEGF);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    105
    Sequence:
    50:
    MRGATRVSIM | LLLVTVSDCA | VITGACERDV | QCGAGTCCAI | SLWLRGLRMC | 
    100:
    TPLGREGEEC | HPGSHKVPFF | RKRKHHTCPC | LPNLLCSRFP | DGRYRCSMDL | 
    105:
    KNINF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Prokineticin-1
    Cat.:
    E0024h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Prokineticin-1
    Cat.:
    E0024m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Prokineticin-1
    Cat.:
    E0024r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Prokineticin-1
    Cat.:
    U0024h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Prokineticin-1
    Cat.:
    U0024m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Prokineticin-1
    Cat.:
    U0024r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Prokineticin-1
    Cat.:
    P0024Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prokineticin-1
    Cat.:
    P0024Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prokineticin-1
    Cat.:
    P0024Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Prokineticin-1
    Monoclonal Antibody for Human Prokineticin-1
    Monoclonal Antibody for Human Prokineticin-1
    Protein for Human Prokineticin-1
    Protein for Human Prokineticin-1
    Protein for Human Prokineticin-1

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    Linearity
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    References
    1. 1.
      "Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle."
      Li M. , Bullock C.M. , Knauer D.J. , Ehlert F.J. , Zhou Q.-Y.
      Mol. Pharmacol.59:692-698(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
    2. 2.
      "Identification of an angiogenic mitogen selective for endocrine gland endothelium."
      LeCouter J. , Kowalski J. , Foster J. , Hass P. , Zhang Z. , Dillard-Telm L. , Frantz G. , Rangell L. , DeGuzman L. , Keller G.-A. , Peale F. , Gurney A. , Hillan K.J. , Ferrara N.
      Nature412:877-884(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
    3. 3.
      "Mambakine, a snake venom related endocrine hormone that controls macrophages."
      Fraser C.
      Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ILE-67
      tissue: Testis.
    8. 8.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-34
    9. 9.
      "Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis."
      Samson M. , Peale F.V. Jr. , Frantz G. , Rioux-Leclercq N. , Rajpert-De Meyts E. , Ferrara N.
      J. Clin. Endocrinol. Metab.89:4078-4088(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    10. 10.
      "Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression."
      Ngan E.S.W. , Sit F.Y.L. , Lee K.L. , Miao X. , Yuan Z. , Wang W. , Nicholls J.M. , Wong K.K.Y. , Garcia-Barcelo M. , Lui V.C.H. , Tam P.K.H.
      Clin. Cancer Res.13:868-875(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Prokineticin 1 signaling and gene regulation in early human pregnancy."
      Evans J. , Catalano R.D. , Morgan K. , Critchley H.O.D. , Millar R.P. , Jabbour H.N.
      Endocrinology149:2877-2887(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
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