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Index > Protein center > PTH(Gene name) > Human
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  • PTH (Gene name),
  • Parathyroid hormone (Protein name ),  PTHY_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    PTH;
    Protein name:
    Parathyroid hormone(PTH);
    Alternative:
    Parathyrin;Parathormone;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PTH1R (via N-terminal extracellular domain).
    Function:
    PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    115
    Sequence:
    50:
    MIPAKDMAKV | MIVMLAICFL | TKSDGKSVKK | RSVSEIQLMH | NLGKHLNSME | 
    100:
    RVEWLRKKLQ | DVHNFVALGA | PLAPRDAGSQ | RPRKKEDNVL | VESHEKSLGE | 
    115:
    ADKADVNVLT | KAKSQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human PTH
    Cat.:
    E0866r
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    96T
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    ELISA Kit for Human PTH
    Cat.:
    E0866b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PTH
    Cat.:
    E0866h
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    MSDS:
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    96T
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    ELISA Kit for Human PTH
    Cat.:
    E0866p
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    96T
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    ELISA Kit for Human PTH
    Cat.:
    E0866d
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PTH
    Cat.:
    E0866c
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human PTH
    Cat.:
    U0866r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PTH
    Cat.:
    U0866h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PTH
    Cat.:
    U0866c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PTH
    Cat.:
    U0866p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PTH
    Cat.:
    U0866b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PTH
    Cat.:
    U0866d
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PTH
    Polyclonal Antibody for Human PTH
    Polyclonal Antibody for Human PTH
    Polyclonal Antibody for Human PTH
    Cat.:
    P0866Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PTH
    Cat.:
    P0866Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PTH
    Monoclonal Antibody for Human PTH
    Monoclonal Antibody for Human PTH
    Monoclonal Antibody for Human PTH
    Monoclonal Antibody for Human PTH
    Monoclonal Antibody for Human PTH
    Monoclonal Antibody for Human PTH
    Protein for Human PTH
    Protein for Human PTH
    Protein for Human PTH
    Protein for Human PTH
    Protein for Human PTH
    Protein for Human PTH

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    References
    1. 1.
      "Nucleotide sequence of cloned cDNAs encoding human preproparathyroid hormone."
      Hendy G.N. , Kronenberg H.M. , Potts J.T. Jr. , Rich A.
      Proc. Natl. Acad. Sci. U.S.A.78:7365-7369(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Inefficient membrane targeting, translocation, and proteolytic processing by signal peptidase of a mutant preproparathyroid hormone protein."
      Karaplis A.C. , Lim S.-K. , Baba H. , Arnold A. , Kronenberg H.M.
      J. Biol. Chem.270:1629-1635(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31;MUTAGENESIS OF ALA-16;VARIANT ARG-18
    5. 5.
      "Structural analysis of human proparathyroid hormone by a new microsequencing approach."
      Jacobs J.W. , Kemper B. , Niall H.D. , Habener J.F. , Potts J.T. Jr.
      Nature249:155-157(1974) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-37
    6. 6.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-40
    7. 7.
      "The amino-acid sequence of the amino-terminal 37 residues of human parathyroid hormone."
      Niall H.D. , Sauer R.T. , Jacobs J.W. , Keutmann H.T. , Segre G.V. , O'Riordan J.L.H. , Aurbach G.D. , Potts J.T. Jr.
      Proc. Natl. Acad. Sci. U.S.A.71:384-388(1974) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-68
    8. 8.
      "Complete amino acid sequence of human parathyroid hormone."
      Keutmann H.T. , Sauer M.M. , Hendy G.N. , O'Riordan J.L.H. , Potts J.T. Jr.
      Biochemistry17:5723-5729(1978) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 61-83 AND 84-115
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 75-100
    10. 10.
      "A reinvestigation of the amino-terminal sequence of human parathyroid hormone."
      Keutmann H.T. , Niall H.D. , O'Riordan J.L.H. , Potts J.T. Jr.
      Biochemistry14:1842-1847(1975) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    11. 11.
      "Solid-phase synthesis of the biologically active N-terminal 1-34 peptide of human parathyroid hormone."
      Tregear G.W. , van Rietschoten J. , Green E. , Niall H.D. , Keutmann H.T. , Parsons J.A. , O'Riordan J.L.H. , Potts J.T. Jr.
      Hoppe-Seyler's Z. Physiol. Chem.355:415-421(1974) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 32-65
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 32-65
    13. 13.
      "Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I."
      Zoidis E. , Ghirlanda-Keller C. , Schmid C.
      Mol. Cell. Biochem.348:33-42(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Investigation of the solution structure of the human parathyroid hormone fragment (1-34) by 1H NMR spectroscopy, distance geometry, and molecular dynamics calculations."
      Klaus W. , Dieckmann T. , Wray V. , Schomburg D. , Wingender E. , Mayer H.
      Biochemistry30:6936-6942(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 32-65
    15. 15.
      "Stabilized NMR structure of human parathyroid hormone(1-34)."
      Barden J.A. , Cuthbertson R.M.
      Eur. J. Biochem.215:315-321(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 32-65
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 32-68
    17. 17.
      "Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37)."
      Marx U.C. , Adermann K. , Bayer P. , Forssmann W.-G. , Rosch P.
      Biochem. Biophys. Res. Commun.267:213-220(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 32-70
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.9 ANGSTROMS) OF 32-65
    19. 19.
      "Molecular recognition of parathyroid hormone by its G protein-coupled receptor."
      Pioszak A.A. , Xu H.E.
      Proc. Natl. Acad. Sci. U.S.A.105:5034-5039(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 46-65 IN COMPLEX WITH PTH1R;INTERACTION WITH PTH1R;MUTAGENESIS OF ARG-51; TRP-54; LEU-55; LYS-58 AND LEU-59
    20. 20.
      "Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism."
      Arnold A. , Horst S.A. , Gardella T.J. , Baba H. , Levine M.A. , Kronenberg H.M.
      J. Clin. Invest.86:1084-1087(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FIH ARG-18
    21. 21.
      "A novel mutation of the signal peptide of the preproparathyroid hormone gene associated with autosomal recessive familial isolated hypoparathyroidism."
      Sunthornthepvarakul T. , Churesigaew S. , Ngowngarmratana S.
      J. Clin. Endocrinol. Metab.84:3792-3796(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FIH PRO-23
    22. 22.
      "Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone."
      Datta R. , Waheed A. , Shah G.N. , Sly W.S.
      Proc. Natl. Acad. Sci. U.S.A.104:19989-19994(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT FIH ARG-18
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