PVRL1 ELISA Kit for Human(Homo sapiens) | EIAab.comPVRL1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PVRL1(Gene name) > Human

PVRL1 (Gene name),

Poliovirus receptor-related protein 1 (Protein name ), PVRL1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PVRL1(HVEC;PRR1);

Protein name:

Poliovirus receptor-related protein 1;

Alternative:

Herpesvirus Ig-like receptor(HIgR);Herpes virus entry mediator C(Herpesvirus entry mediator C;HveC);Nectin-1;

CD:

CD111;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Can form trans-heterodimers with PVRL3/nectin-3 and with PVRL4/nectin-4. Interacts (via C-terminus) with afadin (via PDZ domain); this interaction recruits PVRL1 to cadherin-based adherens junctions. Interacts with integrin alphaV/beta3. Interacts with herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.

Function:

Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.

Subcellular Location:

Isoform Gamma Secreted

Protein Attributes:

Sequence length:

517

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

517:

MVSQNDGSFI | SKKEWYV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08205

KEGG:

hsa:5818

UniGene:

Hs.334846

STRING:

9606.ENSP00000264025

String:

Q15223

MIM:

225060

SMR:

Q15223

Uniprot:

Q15223

FOR

ELISA Kit for Human Poliovirus receptor-related protein 1

Cat.:

E1711h

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96T

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ELISA Kit for Human Poliovirus receptor-related protein 1

Cat.:

E1711m

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96T

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ELISA Kit for Human Poliovirus receptor-related protein 1

Cat.:

E1711p

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Packing:

96T

CLIA Kit for Human Poliovirus receptor-related protein 1

Cat.:

U1711p

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Packing:

96T

CLIA Kit for Human Poliovirus receptor-related protein 1

Cat.:

U1711h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Poliovirus receptor-related protein 1

Cat.:

U1711m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Poliovirus receptor-related protein 1

Cat.:

P1711Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Poliovirus receptor-related protein 1

Cat.:

P1711Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Poliovirus receptor-related protein 1

Protein for Human Poliovirus receptor-related protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"cDNA characterization and chromosomal localization of a gene related to the poliovirus receptor gene."
Lopez M. , Eberle F. , Mattei M.-G. , Gabert J. , Bardin F. , Maroc C. , Dubreuil P.
Gene155:261-265(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA);FUNCTION AS A RECEPTOR FOR HHV-1; HHV-2 AND PRV
2.

"Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor."
Geraghty R.J. , Krummenacher C. , Cohen G.H. , Eisenberg R.J. , Spear P.G.
Science280:1618-1620(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA)
3.

"Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or prr1-HIgR-Hvec) modulates positively and negatively susceptibility to hsv infection."
Lopez M. , Cocchi F. , Avitabile E. , Leclerc A. , Adelaide J. , Campadelli-Fjume G. , Dubreuil P.
J. Virol.75:5684-5691(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GAMMA)
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA)
tissue: Brain.
5.

"Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia."
Suzuki K. , Hu D. , Bustos T. , Zlotogora J. , Richieri-Costa A. , Helms J.A. , Spritz R.A.
Nat. Genet.25:427-430(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-517 (ISOFORMS ALPHA AND DELTA);DISEASE
6.

"Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry."
Krummenacher C. , Nicola A.V. , Whitbeck J.C. , Lou H. , Hou W. , Lambris J.D. , Geraghty R.J. , Spear P.G. , Cohen G.H. , Eisenberg R.J.
J. Virol.72:7064-7074(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-1 AND HHV-2 GLYCOPROTEIN D
7.

"Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein."
Takahashi K. , Nakanishi H. , Miyahara M. , Mandai K. , Satoh K. , Satoh A. , Nishioka H. , Aoki J. , Nomoto A. , Mizoguchi A. , Takai Y.
J. Cell Biol.145:539-549(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AFADIN
8.

"Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction."
Reymond N. , Fabre S. , Lecocq E. , Adelaide J. , Dubreuil P. , Lopez M.
J. Biol. Chem.276:43205-43215(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PVRL3 AND PVRL4
9.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-202
tissue: Plasma.
10.

"Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions."
Sakamoto Y. , Ogita H. , Hirota T. , Kawakatsu T. , Fukuyama T. , Yasumi M. , Kanzaki N. , Ozaki M. , Takai Y.
J. Biol. Chem.281:19631-19644(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ITGAV/ITGB3
11.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-202
12.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-332
tissue: Leukemic T-cell.
13.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
14.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422 AND SER-434;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion."
Zhang N. , Yan J. , Lu G. , Guo Z. , Fan Z. , Wang J. , Shi Y. , Qi J. , Gao G.F.
Nat. Commun.2:577-577(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 30-335 IN COMPLEX WITH HERPES SIMPLEX VIRUS GLYCOPROTEIN D;SUBUNIT;DISULFIDE BONDS
16.

"Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1."
Di Giovine P. , Settembre E.C. , Bhargava A.K. , Luftig M.A. , Lou H. , Cohen G.H. , Eisenberg R.J. , Krummenacher C. , Carfi A.
PLoS Pathog.7:E1002277-E1002277(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 31-345 IN COMPLEX WITH HERPES SIMPLEX VIRUS GLYCOPROTEIN D;FUNCTION;SUBUNIT;MUTAGENESIS OF ASN-82; SER-84 AND PHE-129;DISULFIDE BONDS;GLYCOSYLATION AT ASN-72; ASN-139 AND ASN-202
17.

"Nectin ectodomain structures reveal a canonical adhesive interface."
Harrison O.J. , Vendome J. , Brasch J. , Jin X. , Hong S. , Katsamba P.S. , Ahlsen G. , Troyanovsky R.B. , Troyanovsky S.M. , Honig B. , Shapiro L.
Nat. Struct. Mol. Biol.19:906-915(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 31-337;SUBUNIT;GLYCOSYLATION AT ASN-202;DISULFIDE BONDS;IDENTIFICATION BY MASS SPECTROMETRY

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