Gene name:
PXDN (KIAA0230;MG50;PRG2;VPO;VPO1) ;
Protein name:
Peroxidasin homolog ;
Alternative:
Vascular peroxidase 1 ;Melanoma-associated antigen MG50 ;p53-responsive gene 2 protein ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Enriched in the peritubular space of fibrotic kidneys.
Protein Attributes:
50:
MAKRSRGPGR | RCLLALVLFC | AWGTLAVVAQ | KPGAGCPSRC | LCFRTTVRCM |
100:
HLLLEAVPAV | APQTSILDLR | FNRIREIQPG | AFRRLRNLNT | LLLNNNQIKR |
150:
IPSGAFEDLE | NLKYLYLYKN | EIQSIDRQAF | KGLASLEQLY | LHFNQIETLD |
200:
PDSFQHLPKL | ERLFLHNNRI | THLVPGTFNH | LESMKRLRLD | SNTLHCDCEI |
250:
LWLADLLKTY | AESGNAQAAA | ICEYPRRIQG | RSVATITPEE | LNCERPRITS |
300:
EPQDADVTSG | NTVYFTCRAE | GNPKPEIIWL | RNNNELSMKT | DSRLNLLDDG |
350:
TLMIQNTQET | DQGIYQCMAK | NVAGEVKTQE | VTLRYFGSPA | RPTFVIQPQN |
400:
TEVLVGESVT | LECSATGHPP | PRISWTRGDR | TPLPVDPRVN | ITPSGGLYIQ |
450:
NVVQGDSGEY | ACSATNNIDS | VHATAFIIVQ | ALPQFTVTPQ | DRVVIEGQTV |
500:
DFQCEAKGNP | PPVIAWTKGG | SQLSVDRRHL | VLSSGTLRIS | GVALHDQGQY |
550:
ECQAVNIIGS | QKVVAHLTVQ | PRVTPVFASI | PSDTTVEVGA | NVQLPCSSQG |
600:
EPEPAITWNK | DGVQVTESGK | FHISPEGFLT | INDVGPADAG | RYECVARNTI |
650:
GSASVSMVLS | VNVPDVSRNG | DPFVATSIVE | AIATVDRAIN | STRTHLFDSR |
700:
PRSPNDLLAL | FRYPRDPYTV | EQARAGEIFE | RTLQLIQEHV | QHGLMVDLNG |
750:
TSYHYNDLVS | PQYLNLIANL | SGCTAHRRVN | NCSDMCFHQK | YRTHDGTCNN |
800:
LQHPMWGASL | TAFERLLKSV | YENGFNTPRG | INPHRLYNGH | ALPMPRLVST |
850:
TLIGTETVTP | DEQFTHMLMQ | WGQFLDHDLD | STVVALSQAR | FSDGQHCSNV |
900:
CSNDPPCFSV | MIPPNDSRAR | SGARCMFFVR | SSPVCGSGMT | SLLMNSVYPR |
950:
EQINQLTSYI | DASNVYGSTE | HEARSIRDLA | SHRGLLRQGI | VQRSGKPLLP |
1000:
FATGPPTECM | RDENESPIPC | FLAGDHRANE | QLGLTSMHTL | WFREHNRIAT |
1050:
ELLKLNPHWD | GDTIYYETRK | IVGAEIQHIT | YQHWLPKILG | EVGMRTLGEY |
1100:
HGYDPGINAG | IFNAFATAAF | RFGHTLVNPL | LYRLDENFQP | IAQDHLPLHK |
1150:
AFFSPFRIVN | EGGIDPLLRG | LFGVAGKMRV | PSQLLNTELT | ERLFSMAHTV |
1200:
ALDLAAINIQ | RGRDHGIPPY | HDYRVYCNLS | AAHTFEDLKN | EIKNPEIREK |
1250:
LKRLYGSTLN | IDLFPALVVE | DLVPGSRLGP | TLMCLLSTQF | KRLRDGDRLW |
1300:
YENPGVFSPA | QLTQIKQTSL | ARILCDNADN | ITRVQSDVFR | VAEFPHGYGS |
1350:
CDEIPRVDLR | VWQDCCEDCR | TRGQFNAFSY | HFRGRRSLEF | SYQEDKPTKK |
1400:
TRPRKIPSVG | RQGEHLSNST | SAFSTRSDAS | GTNDFREFVL | EMQKTITDLR |
1450:
TQIKKLESRL | STTECVDAGG | ESHANNTKWK | KDACTICECK | DGQVTCFVEA |
1479:
CPPATCAVPV | NIPGACCPVC | LQKRAEEKP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Peroxidasin homolog
ELISA Kit for Human Peroxidasin homolog
CLIA Kit for Human Peroxidasin homolog
CLIA Kit for Human Peroxidasin homolog
Polyclonal Antibody for Human Peroxidasin homolog
Polyclonal Antibody for Human Peroxidasin homolog
Monoclonal Antibody for Human Peroxidasin homolog
Monoclonal Antibody for Human Peroxidasin homolog
Protein for Human Peroxidasin homolog
Protein for Human Peroxidasin homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Citations
[1].
Ji Fei Zhang , Fu Sheng Zhao, Geng Wu, Qing Fei Kong, Bo Sun, Jingyan Cao, Yao Zhang, Jing Hua Wang, Jing Zhang, Xu Dong Jin , Hu Lun Li
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION;TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);3D-STRUCTURE MODELING;FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;HEME COFACTOR;TISSUE SPECIFICITY
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Bone marrow .
5.
Mural R.J.
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Istrail S.
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Sutton G.G.
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Florea L.
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Halpern A.L.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1479 (ISOFORM 2)
tissue :
Chondrosarcoma .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1176 AND SER-1180;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
9.
"Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney."
Peterfi Z.
,
Donko A.
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Orient A.
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Sum A.
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Prokai A.
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Molnar B.
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Vereb Z.
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Rajnavolgyi E.
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Geiszt M.
Am. J. Pathol.175:725-735(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION BY TGFB1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1178
tissue :
Liver .
11.
"Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma."
Khan K.
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Rudkin A.
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Parry D.A.
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Burdon K.P.
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McKibbin M.
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Logan C.V.
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more...
Am. J. Hum. Genet.89:464-473(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN COPOA;VARIANT COPOA CYS-880