Rad9a ELISA Kit for Mouse(Mus musculus) | EIAab.comRad9a ELISA Kit for Mouse(Mus musculus)

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Rad9a (Gene name),

Cell cycle checkpoint control protein RAD9A (Protein name ), RAD9A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Rad9a(Rad9);

Protein name:

Cell cycle checkpoint control protein RAD9A(mRAD9);

Alternative:

Rad9-like protein;DNA repair exonuclease rad9 homolog A;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. RAD9A interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1 and RPA2. Interacts with DNAJC7 and RHINO (By similarity). Interacts with ATAD5.

Function:

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHINO to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

389

Sequence:

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