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Index > Protein center > AGER(Gene name) > Human
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  • AGER (Gene name),
  • Advanced glycosylation end product-specific receptor (Protein name ),  RAGE_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    AGER(RAGE);
    Protein name:
    Advanced glycosylation end product-specific receptor;
    Alternative:
    Receptor for advanced glycosylation end products;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with S100B, S100A1 and APP (By similarity). Interacts with S100A12.
    Function:
    Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
    Subcellular Location:
    Isoform 2 Secreted
    Protein Attributes:
    Sequence length:
    404
    Sequence:
    50:
    MAAGTAVGAW | VLVLSLWGAV | VGAQNITARI | GEPLVLKCKG | APKKPPQRLE | 
    100:
    WKLNTGRTEA | WKVLSPQGGG | PWDSVARVLP | NGSLFLPAVG | IQDEGIFRCQ | 
    150:
    AMNRNGKETK | SNYRVRVYQI | PGKPEIVDSA | SELTAGVPNK | VGTCVSEGSY | 
    200:
    PAGTLSWHLD | GKPLVPNEKG | VSVKEQTRRH | PETGLFTLQS | ELMVTPARGG | 
    250:
    DPRPTFSCSF | SPGLPRHRAL | RTAPIQPRVW | EPVPLEEVQL | VVEPEGGAVA | 
    300:
    PGGTVTLTCE | VPAQPSPQIH | WMKDGVPLPL | PPSPVLILPE | IGPQDQGTYS | 
    350:
    CVATHSSHGP | QESRAVSISI | IEPGEEGPTA | GSVGGSGLGT | LALALGILGG | 
    400:
    LGTAALLIGV | ILWQRRQRRG | EERKAPENQE | EEEERAELNQ | SEEPEAGESS | 
    404:
    TGGP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    SMR:
    MIM:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Advanced glycosylation end product-specific receptor
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    ELISA Kit for Human Advanced glycosylation end product-specific receptor
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    ELISA Kit for Human Advanced glycosylation end product-specific receptor
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    ELISA Kit for Human Advanced glycosylation end product-specific receptor
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    CLIA Kit for Human Advanced glycosylation end product-specific receptor
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    CLIA Kit for Human Advanced glycosylation end product-specific receptor
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    CLIA Kit for Human Advanced glycosylation end product-specific receptor
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    U1956b
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    CLIA Kit for Human Advanced glycosylation end product-specific receptor
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    Packing:
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    Polyclonal Antibody for Human Advanced glycosylation end product-specific receptor
    Polyclonal Antibody for Human Advanced glycosylation end product-specific receptor
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    P1956Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human Advanced glycosylation end product-specific receptor
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    Polyclonal Antibody for Human Advanced glycosylation end product-specific receptor
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Advanced glycosylation end product-specific receptor
    Monoclonal Antibody for Human Advanced glycosylation end product-specific receptor
    Monoclonal Antibody for Human Advanced glycosylation end product-specific receptor
    Monoclonal Antibody for Human Advanced glycosylation end product-specific receptor
    Protein for Human Advanced glycosylation end product-specific receptor
    Protein for Human Advanced glycosylation end product-specific receptor
    Protein for Human Advanced glycosylation end product-specific receptor
    Protein for Human Advanced glycosylation end product-specific receptor

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    References
    1. 1.
      "Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins."
      Neeper M. , Schmidt A.M. , Brett J. , Yan S.D. , Wang F. , Pan Y.C. , Elliston K. , Stern D. , Shaw A.
      J. Biol. Chem.267:14998-15004(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lung.
    2. 2.
      "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3."
      Sugaya K. , Fukagawa T. , Matsumoto K. , Mita K. , Takahashi E. , Ando A. , Inoko H. , Ikemura T.
      Genomics23:408-419(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    3. 3.
      "Molecular heterogeneity of the receptor for advanced glycation endproducts."
      Abedin M.J. , Yonekura H. , Migita H. , Karasawa J. , Yamamoto Y. , Yamamoto H.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-100
    4. 4.
      "cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products (RAGE) and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein."
      Malherbe P. , Richards J. , Gaillard H. , Thompson A. , Diener C. , Schuler A. , Huber G.
      Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      "Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury."
      Yonekura H. , Yamamoto Y. , Sakurai S. , Petrova R.G. , Abedin J. , Li H. , Yasui K. , Takeuchi M. , Makita Z. , Takasawa S. , Okamoto H. , Watanabe T. , Yamamoto H.
      Biochem. J.370:1097-1109(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);ALTERNATIVE SPLICING
      tissue: Skin.
    6. 6.
      "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
      Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Identification, classification, and expression of RAGE gene splice variants."
      Hudson B.I. , Carter A.M. , Harja E. , Kalea A.Z. , Arriero M. , Yang H. , Grant P.J. , Schmidt A.M.
      FASEB J.22:1572-1580(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6; 7; 8 AND 9);ALTERNATIVE SPLICING
      tissue: Aortic smooth muscle.
      tissue: Lung.
    8. 8.
      "Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function."
      Jules J. , Maiguel D. , Hudson B.I.
      PLoS ONE8:E78267-E78267(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10);SUBCELLULAR LOCATION (ISOFORM 10)
      tissue: Lung.
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    10. 10.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-82
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    13. 13.
      "Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy."
      Hudson B.I. , Stickland M.H. , Futers T.S. , Grant P.J.
      Diabetes50:1505-1511(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12
    14. 14.
      "Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function."
      Moroz O.V. , Burkitt W. , Wittkowski H. , He W. , Ianoul A. , Novitskaya V. , Xie J. , Polyakova O. , Lednev I.K. , Shekhtman A. , Derrick P.J. , Bjoerk P. , Foell D. , Bronstein I.B.
      BMC Biochem.10:11-11(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH S100A12
    15. 15.
      "RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease."
      Fang F. , Lue L.-F. , Yan S. , Xu H. , Luddy J.S. , Chen D. , Walker D.G. , Stern D.M. , Yan S. , Schmidt A.M. , Chen J.X. , Yan S.S.
      FASEB J.24:1043-1055(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)."
      Jin Q. , Chen H. , Luo A. , Ding F. , Liu Z.
      PLoS ONE6:E19375-E19375(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH S100A14;FUNCTION
    17. 17.
      "Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis."
      Wei W. , Lampe L. , Park S. , Vangara B.S. , Waldo G.S. , Cabantous S. , Subaran S.S. , Yang D. , Lakatta E.G. , Lin L.
      PLoS ONE7:E50736-E50736(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;INTERCHAIN DISULFIDE BONDS
    18. 18.
      "Solution structure of the third Ig-like domain from human advanced glycosylation end product-specific receptor."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2008-04) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 235-323
    19. 19.
      "The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding."
      Park H. , Adsit F.G. , Boyington J.C.
      J. Biol. Chem.285:40762-40770(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 23-231;FUNCTION;DNA-BINDING;INTERACTION WITH S100B
    20. 20.
      "Structural basis for ligand recognition and activation of RAGE."
      Koch M. , Chitayat S. , Dattilo B.M. , Schiefner A. , Diez J. , Chazin W.J. , Fritz G.
      Structure18:1342-1352(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 23-240;INTERACTION WITH S100B;DISULFIDE BONDS
    21. 21.
      "Advanced glycation end product recognition by the receptor for AGEs."
      Xue J. , Rai V. , Singer D. , Chabierski S. , Xie J. , Reverdatto S. , Burz D.S. , Schmidt A.M. , Hoffmann R. , Shekhtman A.
      Structure19:722-732(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 23-125;FUNCTION;DISULFIDE BONDS
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