Erc1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comErc1 ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Erc1(Gene name) > Rat

Erc1 (Gene name),

ELKS/Rab6-interacting/CAST family member 1 (Protein name ), RB6I2_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Erc1(Cast2;Elks;Rab6ip2);

Protein name:

ELKS/Rab6-interacting/CAST family member 1(ERC-1);

Alternative:

Rab6-interacting protein 2;CAZ-associated structural protein 2(CAST2);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Isoform 1 interacts through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1 (By similarity). Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA.

Function:

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Golgi apparatus membrane Peripheral membrane protein In neurons, isoform 1 is localized to the cytoplasm and to synapses where it is detected in presynaptic nerve terminals close to the active zone. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.

Protein Attributes:

Sequence length:

948

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

948:

VQQLKQQTQN | RMKLMADNYE | DDHFRSSRSN | QTNHKPSPDQ | DEEEGIWA

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

Q811U3

STRING:

10116.ENSRNOP00000046625

UniGene:

Rn.207836

KEGG:

rno:266806

Pfam:

PF10174

Uniprot:

Q811U3

FOR

ELISA Kit for Rat ERC-1

CLIA Kit for Rat ERC-1

Polyclonal Antibody for Rat ERC-1

Monoclonal Antibody for Rat ERC-1

Protein for Rat ERC-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST."
Deguchi-Tawarada M. , Inoue E. , Takao-Rikitsu E. , Inoue M. , Ohtsuka T. , Takai Y.
Genes Cells9:15-23(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH RIMS1 AND CAST1
strain: Sprague-Dawley.
2.

"A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones."
Wang Y. , Liu X. , Biederer T. , Suedhof T.C.
Proc. Natl. Acad. Sci. U.S.A.99:14464-14469(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH RIMS1 AND RIMS2;MUTAGENESIS OF 943-GLU--ALA-948
3.

"Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide."
Lu J. , Li H. , Wang Y. , Sudhof T.C. , Rizo J.
J. Mol. Biol.352:455-466(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 939-948 IN COMPLEX WITH RIMS1;INTERACTION WITH RIMS1

Product Feedback Wall

* Email:
*Comments: