RAD23A ELISA Kit for Human(Homo sapiens) | EIAab.comRAD23A ELISA Kit for Human(Homo sapiens)

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RAD23A (Gene name),

UV excision repair protein RAD23 homolog A (Protein name ), RD23A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RAD23A;

Protein name:

UV excision repair protein RAD23 homolog A(HR23A;hHR23A);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3. Interacts with HIV-1 vpr. Interacts with UBQLN2.

Function:

Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

363

Sequence:

50:

100:

150:

200:

250:

300:

350:

363:

AANFLLSQNF | DDE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

600061

Pfam:

PF00627

UniGene:

Hs.643267

SMR:

P54725

KEGG:

hsa:5886

STRING:

9606.ENSP00000321365

String:

P54725

Uniprot:

P54725

FOR

ELISA Kit for Human HR23A

CLIA Kit for Human HR23A

Polyclonal Antibody for Human HR23A

Monoclonal Antibody for Human HR23A

Protein for Human HR23A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23."
Masutani C. , Sugasawa K. , Yanagisawa J. , Sonoyama T. , Ui M. , Enomoto T. , Takio K. , Tanaka K. , van der Spek P.J. , Bootsma D. , Hoeijmakers J.H.J. , Hanaoka F.
EMBO J.13:1831-1843(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

NIEHS SNPs program
Submitted (2002-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ALA-131 AND MET-200
3.

"Full-length cDNA libraries and normalization."
Li W.B. , Gruber C. , Jessee J. , Polayes D.
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Fetal liver.
4.

"Homo sapiens protein coding cDNA."
Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ALA-131
tissue: Brain.
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue: Pancreas.
tissue: Testis.
7.

"Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair."
Withers-Ward E.S. , Jowett J.B. , Stewart S.A. , Xie Y.M. , Garfinkel A. , Shibagaki Y. , Chow S.A. , Shah N. , Hanaoka F. , Sawitz D.G. , Armstrong R.W. , Souza L.M. , Chen I.S.
J. Virol.71:9732-9742(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 VPR
8.

"Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity."
Sugasawa K. , Ng J.M. , Masutani C. , Maekawa T. , Uchida A. , van der Spek P.J. , Eker A.P. , Rademakers S. , Visser C. , Aboussekhra A. , Wood R.D. , Hanaoka F. , Bootsma D. , Hoeijmakers J.H.
Mol. Cell. Biol.17:6924-6931(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DNA REPAIR
9.

"Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome."
Hiyama H. , Yokoi M. , Masutani C. , Sugasawa K. , Maekawa T. , Tanaka K. , Hoeijmakers J.H. , Hanaoka F.
J. Biol. Chem.274:28019-28025(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMD4
10.

"Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B."
Wang G. , Sawai N. , Kotliarova S. , Kanazawa I. , Nukina N.
Hum. Mol. Genet.9:1795-1803(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATXN3
11.

"Ubiquitin recognition by the DNA repair protein hHR23a."
Wang Q. , Goh A.M. , Howley P.M. , Walters K.J.
Biochemistry42:13529-13535(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;POLYUBIQUITIN-BINDING
12.

"Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains."
Raasi S. , Pickart C.M.
J. Biol. Chem.278:8951-8959(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PROTEASOMAL DEGRADATION;POLYUBIQUITIN-BINDING
13.

"Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A."
Raasi S. , Orlov I. , Fleming K.G. , Pickart C.M.
J. Mol. Biol.341:1367-1379(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN POLYUBIQUITIN-BINDING
14.

"Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B."
Chen L. , Madura K.
FEBS Lett.580:3401-3408(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMD1; PSMC1 AND EEF1A1;MUTAGENESIS OF LYS-8 AND THR-79
15.

"Ubiquitin receptor proteins hHR23a and hPLIC2 interact."
Kang Y. , Zhang N. , Koepp D.M. , Walters K.J.
J. Mol. Biol.365:1093-1101(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBQLN2
16.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
17.

"Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins."
Goh A.M. , Walters K.J. , Elsasser S. , Verma R. , Deshaies R.J. , Finley D. , Howley P.M.
BMC Biochem.9:4-4(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-10; LYS-47 AND THR-77
18.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123; SER-133; SER-205 AND SER-295;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
20.

"HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome."
Li G. , Elder R.T. , Dubrovsky L. , Liang D. , Pushkarsky T. , Chiu K. , Fan T. , Sire J. , Bukrinsky M. , Zhao R.Y.
PLoS ONE5:E11371-E11371(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VIRAL REPLICATION
21.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr."
Dieckmann T. , Withers-Ward E.S. , Jarosinski M.A. , Liu C.F. , Chen I.S.Y. , Feigon J.
Nat. Struct. Biol.5:1042-1047(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 319-363
25.

"Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr."
Withers-Ward E.S. , Mueller T.D. , Chen I.S.Y. , Feigon J.
Biochemistry39:14103-14112(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 319-363;INTERACTION WITH HIV-1 VPR;MUTAGENESIS OF PRO-333
26.

"Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions."
Mueller T.D. , Feigon J.
J. Mol. Biol.319:1243-1255(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 156-204
27.

"Structural determinants for the binding of ubiquitin-like domains to the proteasome."
Mueller T.D. , Feigon J.
EMBO J.22:4634-4645(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-78;INTERACTION WITH PSMD4;MUTAGENESIS OF ILE-49; ILE-54; PHE-71 AND THR-77
28.

"DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a."
Walters K.J. , Lech P.J. , Goh A.M. , Wang Q. , Howley P.M.
Proc. Natl. Acad. Sci. U.S.A.100:12694-12699(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 2-363;INTERACTION WITH PSMD4;MUTAGENESIS OF THR-9 AND ILE-49
29.

"Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction."
Kamionka M. , Feigon J.
Protein Sci.13:2370-2377(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 223-317
30.

"Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain."
Varadan R. , Assfalg M. , Raasi S. , Pickart C. , Fushman D.
Mol. Cell18:687-698(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 315-363

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