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Index > Protein center > RECK(Gene name) > Human
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  • RECK (Gene name),
  • Reversion-inducing cysteine-rich protein with Kazal motifs (Protein name ),  RECK_HUMAN from NCBI database.
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  • Antigen Annotation
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  • Gene name:
    RECK(ST15);
    Protein name:
    Reversion-inducing cysteine-rich protein with Kazal motifs(hRECK);
    Alternative:
    Suppressor of tumorigenicity 15 protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MMP-9.
    Function:
    Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    971
    Sequence:
    50:
    MATVRASLRG | ALLLLLAVAG | VAEVAGGLAP | GSAGALCCNH | SKDNQMCRDV | 
    100:
    CEQIFSSKSE | SRLKHLLQRA | PDYCPETMVE | IWNCMNSSLP | GVFKKSDGWV | 
    150:
    GLGCCELAIA | LECRQACKQA | SSKNDISKVC | RKEYENALFS | CISRNEMGSV | 
    200:
    CCSYAGHHTN | CREYCQAIFR | TDSSPGPSQI | KAVENYCASI | SPQLIHCVNN | 
    250:
    YTQSYPMRNP | TDSLYCCDRA | EDHACQNACK | RILMSKKTEM | EIVDGLIEGC | 
    300:
    KTQPLPQDPL | WQCFLESSQS | VHPGVTVHPP | PSTGLDGAKL | HCCSKANTST | 
    350:
    CRELCTKLYS | MSWGNTQSWQ | EFDRFCEYNP | VEVSMLTCLA | DVREPCQLGC | 
    400:
    RNLTYCTNFN | NRPTELFRSC | NAQSDQGAMN | DMKLWEKGSI | KMPFINIPVL | 
    450:
    DIKKCQPEMW | KAIACSLQIK | PCHSKSRGSI | ICKSDCVEIL | KKCGDQNKFP | 
    500:
    EDHTAESICE | LLSPTDDLKN | CIPLDTYLRP | STLGNIVEEV | THPCNPNPCP | 
    550:
    ANELCEVNRK | GCPSGDPCLP | YFCVQGCKLG | EASDFIVRQG | TLIQVPSSAG | 
    600:
    EVGCYKICSC | GQSGLLENCM | EMHCIDLQKS | CIVGGKRKSH | GTSFSIDCNV | 
    650:
    CSCFAGNLVC | STRLCLSEHS | SEDDRRTFTG | LPCNCADQFV | PVCGQNGRTY | 
    700:
    PSACIARCVG | LQDHQFEFGS | CMSKDPCNPN | PCQKNQRCIP | KPQVCLTTFD | 
    750:
    KFGCSQYECV | PRQLACDQVQ | DPVCDTDHME | HNNLCTLYQR | GKSLSYKGPC | 
    800:
    QPFCRATEPV | CGHNGETYSS | VCAAYSDRVA | VDYYGDCQAV | GVLSEHSSVA | 
    850:
    ECASVKCPSL | LAAGCKPIIP | PGACCPLCAG | MLRVLFDKEK | LDTIAKVTNK | 
    900:
    KPITVLEILQ | KIRMHVSVPQ | CDVFGYFSIE | SEIVILIIPV | DHYPKALQIE | 
    950:
    ACNKEAEKIE | SLINSDSPTL | ASHVPLSALI | ISQVQVSSSV | PSAGVRARPS | 
    971:
    CHSLLLPLSL | GLALHLLWTY | N
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    KEGG:
    Pfam:
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human hRECK
    Cat.:
    E3240h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human hRECK
    Cat.:
    E3240m
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human hRECK
    Cat.:
    U3240h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human hRECK
    Cat.:
    U3240m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human hRECK
    Cat.:
    P3240Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human hRECK
    Cat.:
    P3240Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human hRECK
    Monoclonal Antibody for Human hRECK
    Protein for Human hRECK
    Protein for Human hRECK

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    Linearity
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    References
    1. 1.
      "Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK."
      Takahashi C. , Sheng Z. , Horan T.P. , Kitayama H. , Maki M. , Hitomi K. , Kitaura Y. , Takai S. , Sasahara R.M. , Horimoto A. , Ikawa Y. , Ratzkin B.J. , Arakawa T. , Noda M.
      Proc. Natl. Acad. Sci. U.S.A.95:13221-13226(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION
      tissue: Fibroblast.
    2. 2.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
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