Protein name:
Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) ;
Alternative:
Suppressor of tumorigenicity 15 protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MMP-9.
Function:
Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
Subcellular Location:
Cell membrane
Lipid-anchor
GPI-anchor
Protein Attributes:
50:
MATVRASLRG | ALLLLLAVAG | VAEVAGGLAP | GSAGALCCNH | SKDNQMCRDV |
100:
CEQIFSSKSE | SRLKHLLQRA | PDYCPETMVE | IWNCMNSSLP | GVFKKSDGWV |
150:
GLGCCELAIA | LECRQACKQA | SSKNDISKVC | RKEYENALFS | CISRNEMGSV |
200:
CCSYAGHHTN | CREYCQAIFR | TDSSPGPSQI | KAVENYCASI | SPQLIHCVNN |
250:
YTQSYPMRNP | TDSLYCCDRA | EDHACQNACK | RILMSKKTEM | EIVDGLIEGC |
300:
KTQPLPQDPL | WQCFLESSQS | VHPGVTVHPP | PSTGLDGAKL | HCCSKANTST |
350:
CRELCTKLYS | MSWGNTQSWQ | EFDRFCEYNP | VEVSMLTCLA | DVREPCQLGC |
400:
RNLTYCTNFN | NRPTELFRSC | NAQSDQGAMN | DMKLWEKGSI | KMPFINIPVL |
450:
DIKKCQPEMW | KAIACSLQIK | PCHSKSRGSI | ICKSDCVEIL | KKCGDQNKFP |
500:
EDHTAESICE | LLSPTDDLKN | CIPLDTYLRP | STLGNIVEEV | THPCNPNPCP |
550:
ANELCEVNRK | GCPSGDPCLP | YFCVQGCKLG | EASDFIVRQG | TLIQVPSSAG |
600:
EVGCYKICSC | GQSGLLENCM | EMHCIDLQKS | CIVGGKRKSH | GTSFSIDCNV |
650:
CSCFAGNLVC | STRLCLSEHS | SEDDRRTFTG | LPCNCADQFV | PVCGQNGRTY |
700:
PSACIARCVG | LQDHQFEFGS | CMSKDPCNPN | PCQKNQRCIP | KPQVCLTTFD |
750:
KFGCSQYECV | PRQLACDQVQ | DPVCDTDHME | HNNLCTLYQR | GKSLSYKGPC |
800:
QPFCRATEPV | CGHNGETYSS | VCAAYSDRVA | VDYYGDCQAV | GVLSEHSSVA |
850:
ECASVKCPSL | LAAGCKPIIP | PGACCPLCAG | MLRVLFDKEK | LDTIAKVTNK |
900:
KPITVLEILQ | KIRMHVSVPQ | CDVFGYFSIE | SEIVILIIPV | DHYPKALQIE |
950:
ACNKEAEKIE | SLINSDSPTL | ASHVPLSALI | ISQVQVSSSV | PSAGVRARPS |
971:
CHSLLLPLSL | GLALHLLWTY | N
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human hRECK
ELISA Kit for Human hRECK
Polyclonal Antibody for Human hRECK
Polyclonal Antibody for Human hRECK
Monoclonal Antibody for Human hRECK
Monoclonal Antibody for Human hRECK
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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Linearity
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References
1.
"Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK."
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION
tissue :
Fibroblast .
2.
"DNA sequence and analysis of human chromosome 9."
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Nature429:369-374(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
Mural R.J.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .