Ring1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comRing1 ELISA Kit for Rat(Rattus norvegicus)

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Ring1 (Gene name),

E3 ubiquitin-protein ligase RING1 (Protein name ), RING1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ring1(Rnf1);

Protein name:

E3 ubiquitin-protein ligase RING1;

Alternative:

RING finger protein 1;Polycomb complex protein RING1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Component of chromatin-associated Polycomb (PcG) complexes. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with BMI1, PHC2, PCGF2, RNF2; CBX6, CBX7 and CBX8.

Function:

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Subcellular Location:

Nucleus speckle

Protein Attributes:

Sequence length:

406

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

406:

PTKDPK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.116589

SMR:

Q6MGB6

String:

Q6MGB6

KEGG:

rno:309626

Pfam:

PF00097

Uniprot:

Q6MGB6

FOR

ELISA Kit for Rat E3 ubiquitin-protein ligase RING1

CLIA Kit for Rat E3 ubiquitin-protein ligase RING1

Polyclonal Antibody for Rat E3 ubiquitin-protein ligase RING1

Monoclonal Antibody for Rat E3 ubiquitin-protein ligase RING1

Protein for Rat E3 ubiquitin-protein ligase RING1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The genomic sequence and comparative analysis of the rat major histocompatibility complex."
Hurt P. , Walter L. , Sudbrak R. , Klages S. , Mueller I. , Shiina T. , Inoko H. , Lehrach H. , Guenther E. , Reinhardt R. , Himmelbauer H.
Genome Res.14:631-639(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 2)
strain: Brown Norway.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: Brown Norway.
tissue: Lung.
3.

"Physical mapping of the Ring1, Ring2, Ke6, Ke4, Rxrb, Col11a2 and RT1.Hb genes of the rat major histocompatibility complex."
Walter L. , Fischer K. , Guenther E.
Immunogenetics44:218-221(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-78
strain: Lewis.

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