RIPK2 ELISA Kit for Human(Homo sapiens) | EIAab.comRIPK2 ELISA Kit for Human(Homo sapiens)

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RIPK2 (Gene name),

Receptor-interacting serine/threonine-protein kinase 2 (Protein name ), RIPK2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

RIPK2(UNQ277/PRO314/PRO34092;CARDIAK;RICK;RIP2);

Protein name:

Receptor-interacting serine/threonine-protein kinase 2;

Alternative:

RIP-like-interacting CLARP kinase;CARD-containing interleukin-1 beta-converting enzyme-associated kinase(CARD-containing IL-1 beta ICE-kinase);2.7.10.2;Tyrosine-protein kinase RIPK2);Receptor-interacting protein 2(RIP-2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex. Interacts with NOD1 and NOD2. Interacts with MAP3K4; this interaction sequesters RIPK2 from the NOD2 signaling pathway. Interacts with IKBKG/NEMO. The polyubiquitinated protein interacts with MAP3K7/TAK1.

Function:

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

540

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

540:

FAKVIVQKLK | DNKQMGLQPY | PEILVVSRSP | SLNLLQNKSM |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O43353

UniGene:

Hs.103755

SMR:

O43353

MIM:

603455

Pfam:

PF00619

KEGG:

hsa:8767

STRING:

9606.ENSP00000220751

Uniprot:

O43353

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ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 2

Cat.:

E1786h

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96T

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ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 2

MSDS:

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ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 2

Cat.:

E1786m

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96T

CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 2

Cat.:

U1786m

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Packing:

96T

CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 2

MSDS:

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CLIA Kit for Human Receptor-interacting serine/threonine-protein kinase 2

Cat.:

U1786h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 2

Cat.:

P1786Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 2

Cat.:

P1786Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Receptor-interacting serine/threonine-protein kinase 2

Protein for Human Receptor-interacting serine/threonine-protein kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis."
Inohara N. , del Peso L. , Koseki T. , Chen S. , Nunez G.
J. Biol. Chem.273:12296-12300(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF LYS-47
2.

"RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase."
McCarthy J.V. , Ni J. , Dixit V.M.
J. Biol. Chem.273:16968-16975(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF LYS-47
tissue: Endothelial cell.
3.

"Identification of CARDIAK, a RIP-like kinase that associates with caspase-1."
Thome M. , Hofmann K. , Burns K. , Martinon F. , Bodmer J.-L. , Mattmann C. , Tschopp J.
Curr. Biol.8:885-888(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF ASP-146
tissue: Pancreatic adenocarcinoma.
4.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Synovium.
6.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Skin.
8.

"Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation."
Ruefli-Brasse A.A. , Lee W.P. , Hurst S. , Dixit V.M.
J. Biol. Chem.279:1570-1574(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2."
Dorsch M. , Wang A. , Cheng H. , Lu C. , Bielecki A. , Charron K. , Clauser K. , Ren H. , Polakiewicz R.D. , Parsons T. , Li P. , Ocain T. , Xu Y.
Cell. Signal.18:2223-2229(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-176
10.

"Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK."
Manon F. , Favier A. , Nunez G. , Simorre J.P. , Cusack S.
J. Mol. Biol.365:160-174(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NOD1;MUTAGENESIS OF ARG-444; ARG-483 AND ARG-488
11.

"MEKK4 sequesters RIP2 to dictate NOD2 signal specificity."
Clark N.M. , Marinis J.M. , Cobb B.A. , Abbott D.W.
Curr. Biol.18:1402-1408(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP3K4
12.

"A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation."
Hasegawa M. , Fujimoto Y. , Lucas P.C. , Nakano H. , Fukase K. , Nunez G. , Inohara N.
EMBO J.27:373-383(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKBKG/NEMO AND MAP3K7/TAK1;FUNCTION;UBIQUITINATION AT LYS-209;MUTAGENESIS OF LYS-209
13.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363; SER-527 AND SER-539;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-531;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways."
Tao M. , Scacheri P.C. , Marinis J.M. , Harhaj E.W. , Matesic L.E. , Abbott D.W.
Curr. Biol.19:1255-1263(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY ITCH;INTERACTION WITH NOD2
16.

"Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2."
Bertrand M.J. , Doiron K. , Labbe K. , Korneluk R.G. , Barker P.A. , Saleh M.
Immunity30:789-801(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY BIRC2 AND BIRC3
17.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-363; SER-393; SER-527 AND SER-539;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses."
Tigno-Aranjuez J.T. , Asara J.M. , Abbott D.W.
Genes Dev.24:2666-2677(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-474;MUTAGENESIS OF TYR-474
19.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-529;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."
Bertrand M.J. , Lippens S. , Staes A. , Gilbert B. , Roelandt R. , De Medts J. , Gevaert K. , Declercq W. , Vandenabeele P.
PLoS ONE6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY BIRC2/C-IAP1 AND BIRC3/C-IAP2;INTERACTION WITH BIRC2/C-IAP1; BIRC3/C-IAP2 AND XIAP/BIRC4
22.

"NLRP10 enhances Shigella-induced pro-inflammatory responses."
Lautz K. , Damm A. , Menning M. , Wenger J. , Adam A.C. , Zigrino P. , Kremmer E. , Kufer T.A.
Cell. Microbiol.14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRP10
23.

"Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."
Zhao Y. , Alonso C. , Ballester I. , Song J.H. , Chang S.Y. , Guleng B. , Arihiro S. , Murray P.J. , Xavier R. , Kobayashi K.S. , Reinecker H.C.
Inflamm. Bowel Dis.18:603-612(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH ARHGEF2 AND NOD2;INTERACTION WITH ARHGEF2 AND NOD2;PHOSPHORYLATION AT TYR-381
24.

"OTULIN restricts Met1-linked ubiquitination to control innate immune signaling."
Fiil B.K. , Damgaard R.B. , Wagner S.A. , Keusekotten K. , Fritsch M. , Bekker-Jensen S. , Mailand N. , Choudhary C. , Komander D. , Gyrd-Hansen M.
Mol. Cell50:818-830(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION
25.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-259; VAL-268 AND ASN-313

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