Rnf41 ELISA Kit for Mouse(Mus musculus) | EIAab.comRnf41 ELISA Kit for Mouse(Mus musculus)

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Rnf41 (Gene name),

E3 ubiquitin-protein ligase NRDP1 (Protein name ), RNF41_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Rnf41(Flrf;Nrdp1);

Protein name:

E3 ubiquitin-protein ligase NRDP1;

Alternative:

RING finger protein 41;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with USP8, ERBB3, PARK2 and BIRC6 (By similarity). Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1.

Function:

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, FLRF is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

317

Sequence:

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