Protein name:
E3 ubiquitin ligase RNF4 ;
Alternative:
RING finger protein 4 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer (via RING-type zinc finger domain). Interacts with AR/the androgen receptor and TBP (By similarity). Interacts with PATZ1 (By similarity). Interacts with PML; SUMO1-dependent. Interacts with PML; SUMO2-dependent (By similarity). Interacts with TRPS1; negatively regulates the TRPS1 transcriptional repressor activity. Interacts with GSC2. Interacts with TCF20. Interacts with PARP1.
Function:
E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
Subcellular Location:
Cytoplasm
Nucleus
Nucleus
PML body
Nucleus
nucleoplasm
Protein Attributes:
50:
MSTRNPQRKR | RGGTVNSRQT | QKRTRETTST | PEVSLETEPI | ELVETVGDEI |
100:
VDLTCESLEP | VVVDLTHNDS | VVIVEERRRP | RRNGRRLRQD | HADSCVVSSD |
150:
DEELSRDKDV | YVTTHTPRST | KDDGATGPRP | SGTVSCPICM | DGYSEIVQNG |
194:
RLIVSTECGH | VFCSQCLRDS | LKNANTCPTC | RKKINHKRYH | PIYI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Mouse E3 ubiquitin ligase RNF4
ELISA Kit for Mouse E3 ubiquitin ligase RNF4
ELISA Kit for Mouse E3 ubiquitin ligase RNF4
CLIA Kit for Mouse E3 ubiquitin ligase RNF4
CLIA Kit for Mouse E3 ubiquitin ligase RNF4
CLIA Kit for Mouse E3 ubiquitin ligase RNF4
Polyclonal Antibody for Mouse E3 ubiquitin ligase RNF4
Polyclonal Antibody for Mouse E3 ubiquitin ligase RNF4
Polyclonal Antibody for Mouse E3 ubiquitin ligase RNF4
Monoclonal Antibody for Mouse E3 ubiquitin ligase RNF4
Monoclonal Antibody for Mouse E3 ubiquitin ligase RNF4
Monoclonal Antibody for Mouse E3 ubiquitin ligase RNF4
Protein for Mouse E3 ubiquitin ligase RNF4
Protein for Mouse E3 ubiquitin ligase RNF4
Protein for Mouse E3 ubiquitin ligase RNF4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH GSC2
strain :
CD-1 .
tissue :
Embryo .
2.
"The transcriptional landscape of the mammalian genome."
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[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Bone marrow .
tissue :
Embryo .
tissue :
Kidney .
tissue :
Lymph node .
tissue :
Visual cortex .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 16-178
tissue :
Embryo .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TCF20
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TRPS1
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PARP1
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;AUTOUBIQUITINATION;MUTAGENESIS OF VAL-134; SER-155; VAL-161 AND TYR-193;SUBUNIT