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Index > Protein center > Rnf4(Gene name) > Mouse
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  • Rnf4 (Gene name),
  • E3 ubiquitin ligase RNF4 (Protein name ),  RNF4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Rnf4;
    Protein name:
    E3 ubiquitin ligase RNF4;
    Alternative:
    RING finger protein 4;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer (via RING-type zinc finger domain). Interacts with AR/the androgen receptor and TBP (By similarity). Interacts with PATZ1 (By similarity). Interacts with PML; SUMO1-dependent. Interacts with PML; SUMO2-dependent (By similarity). Interacts with TRPS1; negatively regulates the TRPS1 transcriptional repressor activity. Interacts with GSC2. Interacts with TCF20. Interacts with PARP1.
    Function:
    E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
    Subcellular Location:
    Cytoplasm Nucleus Nucleus PML body Nucleus nucleoplasm
    Protein Attributes:
    Sequence length:
    194
    Sequence:
    50:
    MSTRNPQRKR | RGGTVNSRQT | QKRTRETTST | PEVSLETEPI | ELVETVGDEI | 
    100:
    VDLTCESLEP | VVVDLTHNDS | VVIVEERRRP | RRNGRRLRQD | HADSCVVSSD | 
    150:
    DEELSRDKDV | YVTTHTPRST | KDDGATGPRP | SGTVSCPICM | DGYSEIVQNG | 
    194:
    RLIVSTECGH | VFCSQCLRDS | LKNANTCPTC | RKKINHKRYH | PIYI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    String:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin ligase RNF4
    ELISA Kit for Mouse E3 ubiquitin ligase RNF4
    ELISA Kit for Mouse E3 ubiquitin ligase RNF4
    CLIA Kit for Mouse E3 ubiquitin ligase RNF4
    CLIA Kit for Mouse E3 ubiquitin ligase RNF4
    CLIA Kit for Mouse E3 ubiquitin ligase RNF4
    Polyclonal Antibody for Mouse E3 ubiquitin ligase RNF4
    Polyclonal Antibody for Mouse E3 ubiquitin ligase RNF4
    Polyclonal Antibody for Mouse E3 ubiquitin ligase RNF4
    Monoclonal Antibody for Mouse E3 ubiquitin ligase RNF4
    Monoclonal Antibody for Mouse E3 ubiquitin ligase RNF4
    Monoclonal Antibody for Mouse E3 ubiquitin ligase RNF4
    Protein for Mouse E3 ubiquitin ligase RNF4
    Protein for Mouse E3 ubiquitin ligase RNF4
    Protein for Mouse E3 ubiquitin ligase RNF4

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region."
      Galili N. , Nayak S. , Epstein J.A. , Buck C.A.
      Dev. Dyn.218:102-111(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH GSC2
      strain: CD-1.
      tissue: Embryo.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Bone marrow.
      tissue: Embryo.
      tissue: Kidney.
      tissue: Lymph node.
      tissue: Visual cortex.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3."
      Chiariotti L. , Benvenuto G. , Fedele M. , Santoro M. , Simeone A. , Fusco A. , Bruni C.B.
      Genomics47:258-265(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-178
      tissue: Embryo.
    5. 5.
      "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers."
      Lyngsoe C. , Bouteiller G. , Damgaard C.K. , Ryom D. , Sanchez-Munoz S. , Noerby P.L. , Bonven B.J. , Joergensen P.
      J. Biol. Chem.275:26144-26149(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TCF20
    6. 6.
      "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor."
      Kaiser F.J. , Moeroey T. , Chang G.T. , Horsthemke B. , Luedecke H.J.
      J. Biol. Chem.278:38780-38785(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRPS1
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    8. 8.
      "PARP-1 transcriptional activity is regulated by sumoylation upon heat shock."
      Martin N. , Schwamborn K. , Schreiber V. , Werner A. , Guillier C. , Zhang X.D. , Bischof O. , Seeler J.S. , Dejean A.
      EMBO J.28:3534-3548(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PARP1
    9. 9.
      "RING domain dimerization is essential for RNF4 function."
      Liew C.W. , Sun H. , Hunter T. , Day C.L.
      Biochem. J.431:23-29(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;AUTOUBIQUITINATION;MUTAGENESIS OF VAL-134; SER-155; VAL-161 AND TYR-193;SUBUNIT
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