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Index > Protein center > Rybp(Gene name) > Mouse
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  • Rybp (Gene name),
  • RING1 and YY1-binding protein (Protein name ),  RYBP_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Rybp(Dedaf);
    Protein name:
    RING1 and YY1-binding protein;
    Alternative:
    Death effector domain-associated factor(DED-associated factor);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Interacts with MDM2, and thereby inhibits ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP (By similarity). Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors. Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins. Interacts with ubiquitinated histone H2A.
    Function:
    Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.
    Subcellular Location:
    Nucleus Cytoplasm Nucleus nucleoplasm Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies.
    Protein Attributes:
    Sequence length:
    228
    Sequence:
    50:
    MTMGDKKSPT | RPKRQAKPAA | DEGFWDCSVC | TFRNSAEAFK | CSICDVRKGT | 
    100:
    STRKPRINSQ | LVAQQVAQQY | ATPPPPKKEK | KEKVEKPDKE | KPEKDKDISP | 
    150:
    SVTKKNTNKK | TKPKSDILKD | PPSEANSIQS | ANATTKTSET | NHTSRPRLKN | 
    200:
    VDRSTAQQLA | VTVGNVTVII | TDFKEKTRSS | STSSSTVTSS | AGSEQQNQSS | 
    228:
    SGSESTDKGS | SRSSTPKGDM | SAVNDESF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse RING1 and YY1-binding protein
    ELISA Kit for Mouse RING1 and YY1-binding protein
    CLIA Kit for Mouse RING1 and YY1-binding protein
    CLIA Kit for Mouse RING1 and YY1-binding protein
    Polyclonal Antibody for Mouse RING1 and YY1-binding protein
    Polyclonal Antibody for Mouse RING1 and YY1-binding protein
    Monoclonal Antibody for Mouse RING1 and YY1-binding protein
    Monoclonal Antibody for Mouse RING1 and YY1-binding protein
    Protein for Mouse RING1 and YY1-binding protein
    Protein for Mouse RING1 and YY1-binding protein

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryonic gonad.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    3. 3.
      "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1."
      Garcia E. , Marcos-Gutierrez C. , del Mar Lorente M. , Moreno J.C. , Vidal M.
      EMBO J.18:3404-3418(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-228;INTERACTION WITH YAF2; YY1; CBX2; RING1 AND RNF2
      strain: C57BL/10.
    4. 4.
      "Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing."
      Danen-van Oorschot A.A.M.M. , Voskamp P. , Seelen M.C.M.J. , van Miltenburg M.H.A.M. , Bolk M.W. , Tait S.W. , Boesen-de Cock J.G.R. , Rohn J.L. , Borst J. , Noteborn M.H.M.
      Cell Death Differ.11:564-573(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    5. 5.
      "Rybp/DEDAF is required for early postimplantation and for central nervous system development."
      Pirity M.K. , Locker J. , Schreiber-Agus N.
      Mol. Cell. Biol.25:7193-7202(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    6. 6.
      "The Polycomb-associated protein Rybp is a ubiquitin binding protein."
      Arrigoni R. , Alam S.L. , Wamstad J.A. , Bardwell V.J. , Sundquist W.I. , Schreiber-Agus N.
      FEBS Lett.580:6233-6241(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH RING1 AND RNF2;SUBCELLULAR LOCATION;MUTAGENESIS OF 31-THR-PHE-32;UBIQUITINATION
    7. 7.
      "Rybp interacts with Hippi and enhances Hippi-mediated apoptosis."
      Stanton S.E. , Blanck J.K. , Locker J. , Schreiber-Agus N.
      Apoptosis12:2197-2206(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IFT57;FUNCTION
    8. 8.
      "The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA."
      Neira J.L. , Roman-Trufero M. , Contreras L.M. , Prieto J. , Singh G. , Barrera F.N. , Renart M.L. , Vidal M.
      Biochemistry48:1348-1360(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF2;SUBUNIT;DOMAIN;DNA-BINDING;CIRCULAR DICHROISM
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