Protein name:
RING1 and YY1-binding protein ;
Alternative:
Death effector domain-associated factor (DED-associated factor) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Interacts with MDM2, and thereby inhibits ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP (By similarity). Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors. Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins. Interacts with ubiquitinated histone H2A.
Function:
Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.
Subcellular Location:
Nucleus
Cytoplasm
Nucleus
nucleoplasm
Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies.
Protein Attributes:
50:
MTMGDKKSPT | RPKRQAKPAA | DEGFWDCSVC | TFRNSAEAFK | CSICDVRKGT |
100:
STRKPRINSQ | LVAQQVAQQY | ATPPPPKKEK | KEKVEKPDKE | KPEKDKDISP |
150:
SVTKKNTNKK | TKPKSDILKD | PPSEANSIQS | ANATTKTSET | NHTSRPRLKN |
200:
VDRSTAQQLA | VTVGNVTVII | TDFKEKTRSS | STSSSTVTSS | AGSEQQNQSS |
228:
SGSESTDKGS | SRSSTPKGDM | SAVNDESF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse RING1 and YY1-binding protein
ELISA Kit for Mouse RING1 and YY1-binding protein
CLIA Kit for Mouse RING1 and YY1-binding protein
CLIA Kit for Mouse RING1 and YY1-binding protein
Polyclonal Antibody for Mouse RING1 and YY1-binding protein
Polyclonal Antibody for Mouse RING1 and YY1-binding protein
Monoclonal Antibody for Mouse RING1 and YY1-binding protein
Monoclonal Antibody for Mouse RING1 and YY1-binding protein
Protein for Mouse RING1 and YY1-binding protein
Protein for Mouse RING1 and YY1-binding protein
R&D Technical Data
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Embryonic gonad .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2-228;INTERACTION WITH YAF2; YY1; CBX2; RING1 AND RNF2
strain :
C57BL/10 .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT;INTERACTION WITH RING1 AND RNF2;SUBCELLULAR LOCATION;MUTAGENESIS OF 31-THR-PHE-32;UBIQUITINATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IFT57;FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RNF2;SUBUNIT;DOMAIN;DNA-BINDING;CIRCULAR DICHROISM