Protein name:
Protein S100-B ;
Alternative:
S-100 protein subunit beta ;S-100 protein beta chain ;S100 calcium-binding protein B ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER (By similarity). The S100B dimer interacts with two molecules of CAPZA1.
Function:
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MSELEKAMVA | LIDVFHQYSG | REGDKHKLKK | SELKELINNE | LSHFLEEIKE |
92:
QEVVDKVMET | LDNDGDGECD | FQEFMAFVAM | VTTACHEFFE | HE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
Rabbit
ELISA Kit for Human Protein S100-B
ELISA Kit for Human Protein S100-B
ELISA Kit for Human Protein S100-B
ELISA Kit for Human Protein S100-B
ELISA Kit for Human Protein S100-B
CLIA Kit for Human Protein S100-B
CLIA Kit for Human Protein S100-B
CLIA Kit for Human Protein S100-B
CLIA Kit for Human Protein S100-B
CLIA Kit for Human Protein S100-B
Polyclonal Antibody for Human Protein S100-B
Polyclonal Antibody for Human Protein S100-B
Polyclonal Antibody for Human Protein S100-B
Polyclonal Antibody for Human Protein S100-B
Polyclonal Antibody for Human Protein S100-B
Monoclonal Antibody for Human Protein S100-B
Monoclonal Antibody for Human Protein S100-B
Monoclonal Antibody for Human Protein S100-B
Monoclonal Antibody for Human Protein S100-B
Monoclonal Antibody for Human Protein S100-B
Protein for Human Protein S100-B
Protein for Human Protein S100-B
Protein for Human Protein S100-B
Protein for Human Protein S100-B
Protein for Human Protein S100-B
R&D Technical Data
? ? ? ?? 12% SDS-PAGE analysis
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Precision
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Recovery
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Linearity
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Citations
[1].
R Li, W Xia, Z Zhang, K Wu
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.
"The DNA sequence of human chromosome 21."
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Nature405:311-319(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Skin .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-92
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : METAL ION-BINDING PROPERTIES
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH S100A6
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AGER
10.
"The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A."
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ATAD3A
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PPP5C
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR IN COMPLEX WITH CAPZA1 AND CALCIUM