S1pr1 ELISA Kit for Mouse(Mus musculus) | EIAab.comS1pr1 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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S1pr1 (Gene name),

Sphingosine 1-phosphate receptor 1 (Protein name ), S1PR1_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

S1pr1(Edg1;Lpb1);

Protein name:

Sphingosine 1-phosphate receptor 1(S1P receptor 1;S1P1);

Alternative:

Lysophospholipid receptor B1;Endothelial differentiation G-protein coupled receptor 1;Sphingosine 1-phosphate receptor Edg-1(S1P receptor Edg-1);

CD:

CD363;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

N/A

Function:

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

382

Sequence:

50:

MVSTSIPEVK | ALRSSVSDYG | NYDIIVRHYN | YTGKLNIGAE | KDHGIKLTSV |

100:

VFILICCFII | LENIFVLLTI | WKTKKFHRPM | YYFIGNLALS | DLLAGVAYTA |

150:

NLLLSGATTY | KLTPAQWFLR | EGSMFVALSA | SVFSLLAIAI | ERYITMLKMK |

200:

LHNGSNSSRS | FLLISACWVI | SLILGGLPIM | GWNCISSLSS | CSTVLPLYHK |

250:

HYILFCTTVF | TLLLLSIVIL | YCRIYSLVRT | RSRRLTFRKN | ISKASRSSEK |

300:

SLALLKTVII | VLSVFIACWA | PLFILLLLDV | GCKAKTCDIL | YKAEYFLVLA |

350:

VLNSGTNPII | YTLTNKEMRR | AFIRIVSCCK | CPNGDSAGKF | KRPIIPGMEF |

382:

SRSKSDNSSH | PQKDDGDNPE | TIMSSGNVNS | SS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

String:

Pfam:

KEGG:

UniGene:

Uniprot:

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ELISA Kit for Mouse S1P receptor 1

Cat.:

E1433h

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96T

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ELISA Kit for Mouse S1P receptor 1

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E1433m

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96T

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ELISA Kit for Mouse S1P receptor 1

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E1433r

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ELISA Kit for Mouse S1P receptor 1

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E1433b

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96T

CLIA Kit for Mouse S1P receptor 1

Cat.:

U1433h

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96T

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CLIA Kit for Mouse S1P receptor 1

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U1433m

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96T

CLIA Kit for Mouse S1P receptor 1

Cat.:

U1433r

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96T

CLIA Kit for Mouse S1P receptor 1

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U1433b

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96T

Polyclonal Antibody for Mouse S1P receptor 1

Polyclonal Antibody for Mouse S1P receptor 1

Cat.:

P1433Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse S1P receptor 1

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P1433Rb-h

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Polyclonal Antibody for Mouse S1P receptor 1

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P1433Rb-m

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Monoclonal Antibody for Mouse S1P receptor 1

Monoclonal Antibody for Mouse S1P receptor 1

Monoclonal Antibody for Mouse S1P receptor 1

Monoclonal Antibody for Mouse S1P receptor 1

Protein for Mouse S1P receptor 1

Protein for Mouse S1P receptor 1

Protein for Mouse S1P receptor 1

Protein for Mouse S1P receptor 1

R&D Technical Data

s

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s

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

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Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

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Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
Saliva(n=3)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
Saliva(n=3)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"The mouse gene for the inducible G-protein-coupled receptor edg-1."
Liu C.H. , Hla T.
Genomics43:15-24(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: BALB/c.
tissue: Liver.
2.

"Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate."
Zhang G. , Contos J.J.A. , Weiner J.A. , Fukushima N. , Chun J.
Gene227:89-99(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
strain: 129/SvJ.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Heart.
tissue: Lung.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Eye.
6.

"Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation."
Liu Y. , Wada R. , Yamashita T. , Mi Y. , Deng C.X. , Hobson J.P. , Rosenfeldt H.M. , Nava V.E. , Chae S.S. , Lee M.J. , Liu C.H. , Hla T. , Spiegel S. , Proia R.L.
J. Clin. Invest.106:951-961(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN VASCULAR MATURATION AND CHEMOTAXIS;TISSUE SPECIFICITY
7.

"EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration."
Rosenfeldt H.M. , Hobson J.P. , Maceyka M. , Olivera A. , Nava V.E. , Milstien S. , Spiegel S.
FASEB J.15:2649-2659(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN FIBROBLAST CHEMOTAXIS;DISRUPTION PHENOTYPE
8.

"Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility."
Hobson J.P. , Rosenfeldt H.M. , Barak L.S. , Olivera A. , Poulton S. , Caron M.G. , Milstien S. , Spiegel S.
Science291:1800-1803(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation."
Allende M.L. , Yamashita T. , Proia R.L.
Blood102:3665-3667(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN VASCULAR MATURATION
10.

"Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration."
Allende M.L. , Dreier J.L. , Mandala S. , Proia R.L.
J. Biol. Chem.279:15396-15401(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN T CELL MIGRATION
11.

"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1."
Matloubian M. , Lo C.G. , Cinamon G. , Lesneski M.J. , Xu Y. , Brinkmann V. , Allende M.L. , Proia R.L. , Cyster J.G.
Nature427:355-360(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN T CELL MIGRATION
12.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
13.

"Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids."
Singleton P.A. , Chatchavalvanich S. , Fu P. , Xing J. , Birukova A.A. , Fortune J.A. , Klibanov A.M. , Garcia J.G. , Birukov K.G.
Circ. Res.104:978-986(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis."
Ishii M. , Egen J.G. , Klauschen F. , Meier-Schellersheim M. , Saeki Y. , Vacher J. , Proia R.L. , Germain R.N.
Nature458:524-528(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN OSTEOCLAST MIGRATION AND BONE HOMEOSTASIS
15.

"The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development."
Poulsen R.R. , McClaskey C.M. , Rivkees S.A. , Wendler C.C.
BMC Dev. Biol.11:37-37(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN HEART MORPHOGENESIS AND DEVELOPMENT
16.

"S1P1 inhibits sprouting angiogenesis during vascular development."
Ben Shoham A. , Malkinson G. , Krief S. , Shwartz Y. , Ely Y. , Ferrara N. , Yaniv K. , Zelzer E.
Development139:3859-3869(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN SPROUTING ANGIOGENESIS
17.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT VAL-2 AND LYS-10;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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