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Index > Protein center > S1PR5(Gene name) > Human
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  • S1PR5 (Gene name),
  • Sphingosine 1-phosphate receptor 5 (Protein name ),  S1PR5_HUMAN from NCBI database.
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  • Gene name:
    S1PR5(EDG8);
    Protein name:
    Sphingosine 1-phosphate receptor 5(S1P receptor 5;S1P5);
    Alternative:
    Sphingosine 1-phosphate receptor Edg-8(S1P receptor Edg-8);Endothelial differentiation G-protein-coupled receptor 8;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    398
    Sequence:
    50:
    MESGLLRPAP | VSEVIVLHYN | YTGKLRGARY | QPGAGLRADA | VVCLAVCAFI | 
    100:
    VLENLAVLLV | LGRHPRFHAP | MFLLLGSLTL | SDLLAGAAYA | ANILLSGPLT | 
    150:
    LKLSPALWFA | REGGVFVALT | ASVLSLLAIA | LERSLTMARR | GPAPVSSRGR | 
    200:
    TLAMAAAAWG | VSLLLGLLPA | LGWNCLGRLD | ACSTVLPLYA | KAYVLFCVLA | 
    250:
    FVGILAAICA | LYARIYCQVR | ANARRLPARP | GTAGTTSTRA | RRKPRSLALL | 
    300:
    RTLSVVLLAF | VACWGPLFLL | LLLDVACPAR | TCPVLLQADP | FLGLAMANSL | 
    350:
    LNPIIYTLTN | RDLRHALLRL | VCCGRHSCGR | DPSGSQQSAS | AAEASGGLRR | 
    398:
    CLPPGLDGSF | SGSERSSPQR | DGLDTSGSTG | SPGAPTAART | LVSEPAAD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    KEGG:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
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    ELISA Kit for Human S1P receptor 5
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    ELISA Kit for Human S1P receptor 5
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    ELISA Kit for Human S1P receptor 5
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    ELISA Kit for Human S1P receptor 5
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    CLIA Kit for Human S1P receptor 5
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    CLIA Kit for Human S1P receptor 5
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    U0328r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human S1P receptor 5
    Cat.:
    U0328p
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human S1P receptor 5
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    U0328m
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    Packing:
    96T
    Polyclonal Antibody for Human S1P receptor 5
    Cat.:
    P0328Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human S1P receptor 5
    Cat.:
    P0328Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human S1P receptor 5
    Cat.:
    P0328Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human S1P receptor 5
    Monoclonal Antibody for Human S1P receptor 5
    Monoclonal Antibody for Human S1P receptor 5
    Monoclonal Antibody for Human S1P receptor 5
    Monoclonal Antibody for Human S1P receptor 5
    Protein for Human S1P receptor 5
    Protein for Human S1P receptor 5
    Protein for Human S1P receptor 5
    Protein for Human S1P receptor 5

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    References
    1. 1.
      "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia."
      Kothapalli R. , Kusmartseva I. , Loughran T.P. Jr.
      Biochim. Biophys. Acta1579:117-123(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Lymphocyte.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Mammary gland.
    3. 3.
      "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors."
      Im D.-S. , Clemens J. , Macdonald T.L. , Lynch K.R.
      Biochemistry40:14053-14060(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
    4. 4.
      "Isolation of complete coding sequence for endothelial differentiation, sphingolipid GPCR 8 (EDG8)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S. , Kadowaki S. , Haga T. , Takaesu H. , Mitaku S.
      FEBS Lett.520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    7. 7.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Skin.
    9. 9.
      "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists."
      Niedernberg A. , Scherer C.R. , Busch A.E. , Kostenis E.
      Biochem. Pharmacol.64:1243-1250(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 10.
      "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers."
      Ulfig N. , Briese M.
      Acta Histochem.106:373-378(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;POSSIBLE FUNCTION
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