SLC22A1 ELISA Kit for Human(Homo sapiens) | EIAab.comSLC22A1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SLC22A1(Gene name) > Human

SLC22A1 (Gene name),

Solute carrier family 22 member 1 (Protein name ), S22A1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SLC22A1(OCT1);

Protein name:

Solute carrier family 22 member 1;

Alternative:

Organic cation transporter 1(hOCT1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.

Subcellular Location:

Basolateral cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

554

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

554:

PSGT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000355930

MIM:

602607

KEGG:

hsa:6580

Pfam:

PF00083

UniGene:

Hs.117367

String:

O15245

SMR:

O15245

Uniprot:

O15245

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ELISA Kit for Human Solute carrier family 22 member 1

Cat.:

E15326h

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0.39ng/ml

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ELISA Kit for Human Solute carrier family 22 member 1

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ELISA Kit for Human Solute carrier family 22 member 1

Cat.:

E15326r

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Packing:

96T

ELISA Kit for Human Solute carrier family 22 member 1

Cat.:

E15326m

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96T

ELISA Kit for Human Solute carrier family 22 member 1

Cat.:

E15326b

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96T

ELISA Kit for Human Solute carrier family 22 member 1

Cat.:

E15326p

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96T

CLIA Kit for Human Solute carrier family 22 member 1

Cat.:

U15326p

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Packing:

96T

CLIA Kit for Human Solute carrier family 22 member 1

Cat.:

U15326h

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MSDS:

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Packing:

96T

CLIA Kit for Human Solute carrier family 22 member 1

Cat.:

U15326m

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MSDS:

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Packing:

96T

CLIA Kit for Human Solute carrier family 22 member 1

Cat.:

U15326b

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MSDS:

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Packing:

96T

CLIA Kit for Human Solute carrier family 22 member 1

MSDS:

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CLIA Kit for Human Solute carrier family 22 member 1

Cat.:

U15326r

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Packing:

96T

Polyclonal Antibody for Human Solute carrier family 22 member 1

Cat.:

P15326Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Solute carrier family 22 member 1

Cat.:

P15326Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Solute carrier family 22 member 1

Cat.:

P15326Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Solute carrier family 22 member 1

Protein for Human Solute carrier family 22 member 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of two human polyspecific organic cation transporters."
Gorboulev V. , Ulzheimer J.C. , Akhoundova A. , Ulzheimer-Teuber I. , Karbach U. , Quester S. , Baumann C. , Lang F. , Busch A.E. , Koepsell H.
DNA Cell Biol.16:871-881(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;VARIANT PHE-160
tissue: Liver.
2.

"Cloning and functional expression of a human liver organic cation transporter."
Zhang L. , Dresser M.J. , Gray A.T. , Yost S.C. , Terashita S. , Giacomini K.M.
Mol. Pharmacol.51:913-921(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
3.

"Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)."
Hayer M. , Boenisch H. , Bruess M.
Ann. Hum. Genet.63:473-482(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3 AND 4)
4.

Hayer M. , Bonisch H. , Bruss M.
Ann. Hum. Genet.64:267-267(2000)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS PHE-160; VAL-408; MET-420 DEL AND ARG-465
tissue: Caudate nucleus.
6.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PHE-160
8.

"Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)."
Zhang L. , Schaner M.E. , Giacomini K.M.
J. Pharmacol. Exp. Ther.286:354-361(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
9.

"Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides."
van Montfoort J.E. , Mueller M. , Groothuis G.M.M. , Meijer D.K.F. , Koepsell H. , Meier P.J.
J. Pharmacol. Exp. Ther.298:110-115(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Regulation of the human organic cation transporter hOCT1."
Ciarimboli G. , Struwe K. , Arndt P. , Gorboulev V. , Koepsell H. , Schlatter E. , Hirsch J.R.
J. Cell. Physiol.201:420-428(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)."
Mueller J. , Lips K.S. , Metzner L. , Neubert R.H.H. , Koepsell H. , Brandsch M.
Biochem. Pharmacol.70:1851-1860(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1."
Kimura N. , Masuda S. , Tanihara Y. , Ueo H. , Okuda M. , Katsura T. , Inui K.
Drug Metab. Pharmacokinet.20:379-386(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
13.

"The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha."
Saborowski M. , Kullak-Ublick G.A. , Eloranta J.J.
J. Pharmacol. Exp. Ther.317:778-785(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
14.

"Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain."
Amphoux A. , Vialou V. , Drescher E. , Bruess M. , Mannoury La Cour C. , Rochat C. , Millan M.J. , Giros B. , Boenisch H. , Gautron S.
Neuropharmacology50:941-952(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells."
Dias V. , Ribeiro V.
Fundam. Clin. Pharmacol.21:445-450(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
16.

"Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences."
Kerb R. , Brinkmann U. , Chatskaia N. , Gorbunov D. , Gorboulev V. , Mornhinweg E. , Keil A. , Eichelbaum M. , Koepsell H.
Pharmacogenetics12:591-595(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-61; ARG-88; PHE-160; SER-401 AND MET-420 DEL;CHARACTERIZATION OF VARIANTS CYS-61; ARG-88; PHE-160; SER-401 AND MET-420 DEL
17.

"Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1."
Shu Y. , Leabman M.K. , Feng B. , Mangravite L.M. , Huang C.C. , Stryke D. , Kawamoto M. , Johns S.J. , DeYoung J. , Carlson E. , Ferrin T.E. , Herskowitz I. , Giacomini K.M.
Proc. Natl. Acad. Sci. U.S.A.100:5902-5907(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHE-14; CYS-61; PHE-85; PHE-160; LEU-189; VAL-220; LEU-341; HIS-342; SER-401; VAL-408; MET-420 DEL; ILE-440; ILE-461; ARG-465 AND MET-488;CHARACTERIZATION OF VARIANTS PHE-14; CYS-61; PHE-85; PHE-160; LEU-189; VAL-220; LEU-341; HIS-342; SER-401; VAL-408; MET-420 DEL; ILE-440; ILE-461; ARG-465 AND MET-488;MUTAGENESIS OF GLY-465
18.

"Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions."
Sakata T. , Anzai N. , Shin H.J. , Noshiro R. , Hirata T. , Yokoyama H. , Kanai Y. , Endou H.
Biochem. Biophys. Res. Commun.313:789-793(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHE-160; LEU-283; GLY-287 AND LEU-341
19.

"Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1)."
Itoda M. , Saito Y. , Maekawa K. , Hichiya H. , Komamura K. , Kamakura S. , Kitakaze M. , Tomoike H. , Ueno K. , Ozawa S. , Sawada J.
Drug Metab. Pharmacokinet.19:308-312(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-41; PHE-160; LEU-341 AND VAL-408

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