Gene name:
Slc22a8 (Oat3;Roct) ;
Protein name:
Solute carrier family 22 member 8 ;
Alternative:
Reduced in osteosclerosis transporter ;Organic anion transporter 3 (mOat3) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Mediates the uptake of p-amino-hippurate (PAH) and estron sulfate (ES). Also mediates uptake of several organic compounds such as prostaglandin E(2), prostaglandin F(2-alpha), allopurinol, 6-mercaptopurine (6-MP), 5-fluorouracil (5-FU), and L-carnitine.
Subcellular Location:
Basolateral cell membrane
Multi-pass membrane protein
Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC).
Protein Attributes:
50:
MTFSEILDRV | GSMGPFQYLH | VTLLALPILG | IANHNLLQIF | TATTPDHHCR |
100:
PPPNASLEPW | VLPLGPNGKP | EKCLRFVHLP | NASLPNDTQG | ATEPCLDGWI |
150:
YNSTRDTIVT | EWDLVCGSNK | LKEMAQSVFM | AGILVGGPVF | GELSDRFGRK |
200:
PILTWSYLLL | AASGSSAAFS | PSLTVYMIFR | FLCGCSISGI | SLSTIILNVE |
250:
WVPTSTRAIS | STTIGYCYTI | GQFILPGLAY | AVPQWRWLQL | SVSAAFFIFS |
300:
LLSWWVPESI | RWLVLSGKFS | KALKTLQRVA | TFNGKKEEGE | KLTVEELKFN |
350:
LQKDITSAKV | KYGLSDLFRV | SILRRVTFCL | SLAWFATGFA | YYSLAMGVEE |
400:
FGVNIYILQI | IFGGVDIPAK | FITILSISYL | GRRITQGFLL | ILAGVAILAL |
450:
IFVSSEMQLL | RTALAVFGKG | CLSGSFSCLF | LYTSELYPTV | LRQTGMGISN |
500:
IWARVGSMIA | PLVKITGELQ | PFIPNVIFGT | MTLLGGSAAF | FLLETLNRPL |
537:
PETIEDIQDW | YQQTKKTKQE | PEAEKASQTI | PLKTGGP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Pig
Rabbit
Rat
Human
ELISA Kit for Mouse Solute carrier family 22 member 8
ELISA Kit for Mouse Solute carrier family 22 member 8
ELISA Kit for Mouse Solute carrier family 22 member 8
ELISA Kit for Mouse Solute carrier family 22 member 8
ELISA Kit for Mouse Solute carrier family 22 member 8
CLIA Kit for Mouse Solute carrier family 22 member 8
CLIA Kit for Mouse Solute carrier family 22 member 8
CLIA Kit for Mouse Solute carrier family 22 member 8
CLIA Kit for Mouse Solute carrier family 22 member 8
CLIA Kit for Mouse Solute carrier family 22 member 8
Polyclonal Antibody for Mouse Solute carrier family 22 member 8
Polyclonal Antibody for Mouse Solute carrier family 22 member 8
Polyclonal Antibody for Mouse Solute carrier family 22 member 8
Polyclonal Antibody for Mouse Solute carrier family 22 member 8
Polyclonal Antibody for Mouse Solute carrier family 22 member 8
Monoclonal Antibody for Mouse Solute carrier family 22 member 8
Monoclonal Antibody for Mouse Solute carrier family 22 member 8
Monoclonal Antibody for Mouse Solute carrier family 22 member 8
Monoclonal Antibody for Mouse Solute carrier family 22 member 8
Monoclonal Antibody for Mouse Solute carrier family 22 member 8
Protein for Mouse Solute carrier family 22 member 8
Protein for Mouse Solute carrier family 22 member 8
Protein for Mouse Solute carrier family 22 member 8
Protein for Mouse Solute carrier family 22 member 8
Protein for Mouse Solute carrier family 22 member 8
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue :
Kidney .
2.
"The transcriptional landscape of the mammalian genome."
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Inner ear .
tissue :
Medulla oblongata .
tissue :
Retina .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Kidney .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 13-537
tissue :
Kidney .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY