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Index > Protein center > Slc22a8(Gene name) > Mouse
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  • Slc22a8 (Gene name),
  • Solute carrier family 22 member 8 (Protein name ),  S22A8_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Slc22a8(Oat3;Roct);
    Protein name:
    Solute carrier family 22 member 8;
    Alternative:
    Reduced in osteosclerosis transporter;Organic anion transporter 3(mOat3);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Mediates the uptake of p-amino-hippurate (PAH) and estron sulfate (ES). Also mediates uptake of several organic compounds such as prostaglandin E(2), prostaglandin F(2-alpha), allopurinol, 6-mercaptopurine (6-MP), 5-fluorouracil (5-FU), and L-carnitine.
    Subcellular Location:
    Basolateral cell membrane Multi-pass membrane protein Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC).
    Protein Attributes:
    Sequence length:
    537
    Sequence:
    50:
    MTFSEILDRV | GSMGPFQYLH | VTLLALPILG | IANHNLLQIF | TATTPDHHCR | 
    100:
    PPPNASLEPW | VLPLGPNGKP | EKCLRFVHLP | NASLPNDTQG | ATEPCLDGWI | 
    150:
    YNSTRDTIVT | EWDLVCGSNK | LKEMAQSVFM | AGILVGGPVF | GELSDRFGRK | 
    200:
    PILTWSYLLL | AASGSSAAFS | PSLTVYMIFR | FLCGCSISGI | SLSTIILNVE | 
    250:
    WVPTSTRAIS | STTIGYCYTI | GQFILPGLAY | AVPQWRWLQL | SVSAAFFIFS | 
    300:
    LLSWWVPESI | RWLVLSGKFS | KALKTLQRVA | TFNGKKEEGE | KLTVEELKFN | 
    350:
    LQKDITSAKV | KYGLSDLFRV | SILRRVTFCL | SLAWFATGFA | YYSLAMGVEE | 
    400:
    FGVNIYILQI | IFGGVDIPAK | FITILSISYL | GRRITQGFLL | ILAGVAILAL | 
    450:
    IFVSSEMQLL | RTALAVFGKG | CLSGSFSCLF | LYTSELYPTV | LRQTGMGISN | 
    500:
    IWARVGSMIA | PLVKITGELQ | PFIPNVIFGT | MTLLGGSAAF | FLLETLNRPL | 
    537:
    PETIEDIQDW | YQQTKKTKQE | PEAEKASQTI | PLKTGGP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Solute carrier family 22 member 8
    ELISA Kit for Mouse Solute carrier family 22 member 8
    ELISA Kit for Mouse Solute carrier family 22 member 8
    ELISA Kit for Mouse Solute carrier family 22 member 8
    ELISA Kit for Mouse Solute carrier family 22 member 8
    CLIA Kit for Mouse Solute carrier family 22 member 8
    CLIA Kit for Mouse Solute carrier family 22 member 8
    CLIA Kit for Mouse Solute carrier family 22 member 8
    CLIA Kit for Mouse Solute carrier family 22 member 8
    CLIA Kit for Mouse Solute carrier family 22 member 8
    Polyclonal Antibody for Mouse Solute carrier family 22 member 8
    Polyclonal Antibody for Mouse Solute carrier family 22 member 8
    Polyclonal Antibody for Mouse Solute carrier family 22 member 8
    Polyclonal Antibody for Mouse Solute carrier family 22 member 8
    Polyclonal Antibody for Mouse Solute carrier family 22 member 8
    Monoclonal Antibody for Mouse Solute carrier family 22 member 8
    Monoclonal Antibody for Mouse Solute carrier family 22 member 8
    Monoclonal Antibody for Mouse Solute carrier family 22 member 8
    Monoclonal Antibody for Mouse Solute carrier family 22 member 8
    Monoclonal Antibody for Mouse Solute carrier family 22 member 8
    Protein for Mouse Solute carrier family 22 member 8
    Protein for Mouse Solute carrier family 22 member 8
    Protein for Mouse Solute carrier family 22 member 8
    Protein for Mouse Solute carrier family 22 member 8
    Protein for Mouse Solute carrier family 22 member 8

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse."
      Brady K.P. , Dushkin H. , Foernzler D. , Koike T. , Magner F. , Her H. , Gullans S. , Segre G.V. , Green R.M. , Beier D.R.
      Genomics56:254-261(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Kidney.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Inner ear.
      tissue: Medulla oblongata.
      tissue: Retina.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Kidney.
    4. 4.
      "Cloning and functional characterization of mOAT3 (Roct)."
      Kobayashi Y. , Shibusawa A. , Ohshiro N. , Sasaki T. , Tokuyama S. , Yamamoto T.
      Submitted (2002-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-537
      tissue: Kidney.
    5. 5.
      "Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice."
      Sweet D.H. , Miller D.S. , Pritchard J.B. , Fujiwara Y. , Beier D.R. , Nigam S.K.
      J. Biol. Chem.277:26934-26943(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    6. 6.
      "Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice."
      Sykes D. , Sweet D.H. , Lowes S. , Nigam S.K. , Pritchard J.B. , Miller D.S.
      Am. J. Physiol.286:F972-F978(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3."
      Kobayashi Y. , Ohshiro N. , Tsuchiya A. , Kohyama N. , Ohbayashi M. , Yamamoto T.
      Drug Metab. Dispos.32:479-483(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
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