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Index > Protein center > SLC47A1(Gene name) > Human
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  • SLC47A1 (Gene name),
  • Multidrug and toxin extrusion protein 1 (Protein name ),  S47A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC47A1(MATE1);
    Protein name:
    Multidrug and toxin extrusion protein 1(MATE-1;hMATE-1);
    Alternative:
    Solute carrier family 47 member 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Predominantly localized at the plasma membrane but also found in intracellular organelles.
    Protein Attributes:
    Sequence length:
    570
    Sequence:
    50:
    MEAPEEPAPV | RGGPEATLEV | RGSRCLRLSA | FREELRALLV | LAGPAFLVQL | 
    100:
    MVFLISFISS | VFCGHLGKLE | LDAVTLAIAV | INVTGVSVGF | GLSSACDTLI | 
    150:
    SQTYGSQNLK | HVGVILQRSA | LVLLLCCFPC | WALFLNTQHI | LLLFRQDPDV | 
    200:
    SRLTQTYVTI | FIPALPATFL | YMLQVKYLLN | QGIVLPQIVT | GVAANLVNAL | 
    250:
    ANYLFLHQLH | LGVIGSALAN | LISQYTLALL | LFLYILGKKL | HQATWGGWSL | 
    300:
    ECLQDWASFL | RLAIPSMLML | CMEWWAYEVG | SFLSGILGMV | ELGAQSIVYE | 
    350:
    LAIIVYMVPA | GFSVAASVRV | GNALGAGDME | QARKSSTVSL | LITVLFAVAF | 
    400:
    SVLLLSCKDH | VGYIFTTDRD | IINLVAQVVP | IYAVSHLFEA | LACTSGGVLR | 
    450:
    GSGNQKVGAI | VNTIGYYVVG | LPIGIALMFA | TTLGVMGLWS | GIIICTVFQA | 
    500:
    VCFLGFIIQL | NWKKACQQAQ | VHANLKVNNV | PRSGNSALPQ | DPLHPGCPEN | 
    550:
    LEGILTNDVG | KTGEPQSDQQ | MRQEEPLPEH | PQDGAKLSRK | QLVLRRGLLL | 
    570:
    LGVFLILLVG | ILVRFYVRIQ | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MATE-1
    ELISA Kit for Human MATE-1
    ELISA Kit for Human MATE-1
    ELISA Kit for Human MATE-1
    CLIA Kit for Human MATE-1
    CLIA Kit for Human MATE-1
    CLIA Kit for Human MATE-1
    CLIA Kit for Human MATE-1
    Polyclonal Antibody for Human MATE-1
    Polyclonal Antibody for Human MATE-1
    Polyclonal Antibody for Human MATE-1
    Polyclonal Antibody for Human MATE-1
    Monoclonal Antibody for Human MATE-1
    Monoclonal Antibody for Human MATE-1
    Monoclonal Antibody for Human MATE-1
    Monoclonal Antibody for Human MATE-1
    Protein for Human MATE-1
    Protein for Human MATE-1
    Protein for Human MATE-1
    Protein for Human MATE-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    2. 2.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cerebellum.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Colon.
      tissue: Eye.
    5. 5.
      "A human transporter protein that mediates the final excretion step for toxic organic cations."
      Otsuka M. , Matsumoto T. , Morimoto R. , Arioka S. , Omote H. , Moriyama Y.
      Proc. Natl. Acad. Sci. U.S.A.102:17923-17928(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF GLU-273;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;BIOPHYSICOCHEMICAL PROPERTIES
    6. 6.
      "Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations."
      Hiasa M. , Matsumoto T. , Komatsu T. , Moriyama Y.
      Am. J. Physiol.291:C678-C686(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    7. 7.
      "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations."
      Omote H. , Hiasa M. , Matsumoto T. , Otsuka M. , Moriyama Y.
      Trends Pharmacol. Sci.27:587-593(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters."
      Tanihara Y. , Masuda S. , Sato T. , Katsura T. , Ogawa O. , Inui K.
      Biochem. Pharmacol.74:359-371(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
    9. 9.
      "Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity."
      Yokoo S. , Yonezawa A. , Masuda S. , Fukatsu A. , Katsura T. , Inui K.
      Biochem. Pharmacol.74:477-487(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family."
      Chen Y. , Zhang S. , Sorani M. , Giacomini K.M.
      J. Pharmacol. Exp. Ther.322:695-700(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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