Protein name:
Electrogenic sodium bicarbonate cotransporter 4 ;
Alternative:
Solute carrier family 4 member 5 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Basolateral cell membrane
Multi-pass membrane protein
Localised predominantly to the basolateral sinusoidal membrane in hepatocytes.
Protein Attributes:
50:
MKVEEKAGVK | KLEPTSYRRR | HPEQDFPSIH | IGFPVPGYSQ | RKSDSKGHLS |
100:
GLQRVQWSLQ | PDKSQQDLAG | PDGIKASSLG | GSVDFTKRIR | SPAAEQLQDI |
150:
LGEEDEAPNP | TLFTEMDTLQ | HDGDQMEWKE | SARWIKFEEK | VEEGGERWSK |
200:
PHVSTLSLHS | LFELRTCLQT | GTVLLDLDSG | SLPQIIDDVI | EKQIEGGLLR |
250:
PELRERVSYV | LLRKHRHQTK | KPIHRSLADI | GKSVSTTNRS | SARSPSAGPT |
300:
LHHSTEDLRI | RQSTSYGHLC | HAQSRSMNDI | SHTPNTDQRK | NKFMKKIPKD |
350:
SEASNVLVGE | VDFLDQPFIA | FVRLAQSSML | GGVTEVPVPT | RFLFILLGPS |
400:
GRAKSYNEIG | RAIATLMVDD | LFSDVAYKAR | NREDLIAGVD | EFLDEVIVLP |
450:
PGEWDPNIRI | EPPKKVPSAD | KRKSVFSLAE | LGQMNGSVGR | SGASAGGGGS |
500:
GGGAGGSGAG | GGGSGNEAEM | PAMHEIGEEL | IWTGRFFGGL | RLDVKRKLPW |
550:
FPSDFYDGFH | IQSISAVLFI | YLGCITNAIT | FGGLLGDATD | NYQGVMESFL |
600:
GTAMAGSLFC | LFSGQPLIIL | SSTGPILIFE | KLLFDFSKAN | GLDYMEFRLW |
650:
IGLHSAIQCL | ILVATDASFI | IKYITRFTEE | GFSTLISFIF | IYDAIKKMIG |
700:
AFKYYPINTD | FKPDSITTYK | CECVAPDTVN | TTTVNDSALL | VPNTNMSVYT |
750:
PLNLTALDWS | LLSKKECLSY | GGRLLGSSCQ | FVPDLALMSF | ILFFGTYSMT |
800:
LTLKKFKFSR | YFPTKVRTLV | ADFSIVFSIL | LFCGIDACFG | LQTPKLHVPN |
850:
VIKPTRPDRG | WFVAPFGKNP | WWVYPASILP | ALLVTILIFM | DQQITAVIVN |
900:
RKENKLRKAA | GYHLDLFWVG | ILMALCSFMG | LPWYVAATVI | SIAHIDSLKM |
950:
ETETSAPGEQ | PQFLGVREQR | VTGVMVFILT | GISVFLAPIL | KYIPMPVLYG |
1000:
VFLYMGVASL | NGIQFWDRCK | LFLMPAKHQP | DHAFLRHVPL | RRIHLFTLVQ |
1050:
ILCLALLWIL | KSTMAAIIFP | VMILGLIIVR | RLLDLIFSQH | DLAWIDNILP |
1100:
EKEKKESDRK | KRRKEVHENT | DKEPQFLPPS | VVKIPMEGIP | SDPQNGIHCV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
ELISA Kit for Rat Electrogenic sodium bicarbonate cotransporter 4
ELISA Kit for Rat Electrogenic sodium bicarbonate cotransporter 4
CLIA Kit for Rat Electrogenic sodium bicarbonate cotransporter 4
CLIA Kit for Rat Electrogenic sodium bicarbonate cotransporter 4
Polyclonal Antibody for Rat Electrogenic sodium bicarbonate cotransporter 4
Polyclonal Antibody for Rat Electrogenic sodium bicarbonate cotransporter 4
Monoclonal Antibody for Rat Electrogenic sodium bicarbonate cotransporter 4
Monoclonal Antibody for Rat Electrogenic sodium bicarbonate cotransporter 4
Protein for Rat Electrogenic sodium bicarbonate cotransporter 4
Protein for Rat Electrogenic sodium bicarbonate cotransporter 4
R&D Technical Data
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Precision
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain :
Sprague-Dawley .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY