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Index > Protein center > Slc4a8(Gene name) > Mouse
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  • Slc4a8 (Gene name),
  • Electroneutral sodium bicarbonate exchanger 1 (Protein name ),  S4A8_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Slc4a8(Kiaa0739);
    Protein name:
    Electroneutral sodium bicarbonate exchanger 1;
    Alternative:
    Solute carrier family 4 member 8;Electroneutral Na+-driven Cl-HCO3 exchanger;k-NBC3;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1089
    Sequence:
    50:
    MPAGSNEPDG | VLSYQRPDEE | AVVDQGGTST | ILNIHYEKEE | LEGHRTLYVG | 
    100:
    VRMPLGRQSH | RHHRTHGQKH | RRRGGRGKGA | SQGEEGLEAL | AHDTPSQRVQ | 
    150:
    FILGTEEDEE | HVPHELFTEL | DEICMKEGED | AEWKETARWL | KFEEDVEDGG | 
    200:
    ERWSKPYVAT | LSLHSLFELR | SCLINGSVLL | DMRASSIEEI | SDLILDQQEL | 
    250:
    LRDLSDSVRV | KVREALLKKH | HHQNERRRNN | LIPIVRSFAE | VGKKQSDPHS | 
    300:
    MDRDGQTVSP | QSATNLEVKN | GVNCEHSPVD | LSKVDLHFMK | KIPTGAEASN | 
    350:
    VLVGEVDTLD | RPIVAFVRLS | PAVLLSGLTE | VPIPTRFLFI | LLGPVGKGQQ | 
    400:
    YHEIGRSMAT | IMTDEIFHDV | AYKAKERDDL | LAGIDEFLDQ | VTVLPPGEWD | 
    450:
    PSIRIEPPKN | VPSQEKRKMP | GVPNGNVCHI | EPEPHGGHSG | PELERTGRLF | 
    500:
    GGLVLDVKRK | APWYWSDYRD | ALSLQCLASF | LFLYCACMSP | VITFGGLLGE | 
    550:
    ATEGRISAIE | SLFGASMTGI | AYSLFAGQPL | TILGSTGPVL | VFEKILFKFC | 
    600:
    KDYALSYLSL | RALIGLWTAF | LCIVLVATDA | SSLVCYITRF | TEEAFASLIC | 
    650:
    IIFIYEAIEK | LIHLAETYPI | HMHSQLDHLS | LYYCRCVLPE | NPNNHTLQYW | 
    700:
    KDHNILAAEV | NWANLTVSEC | QEMHGEFMGS | ACGHHGPYTP | DVLFWSCILF | 
    750:
    FATFIVSSTL | KTFKTSRYFP | TRVRSMVSDF | AVFLTIFTMV | VLDFLIGVPS | 
    800:
    PKLQVPNVFK | PTRDDRGWFI | NPIGPNPWWT | VIAAIIPALL | CTILIFMDQQ | 
    850:
    ITAVIINRKE | HKLKKGCGYH | LDLLMVAVML | GVCSIMGLPW | FVAATVLSIT | 
    900:
    HVNSLKLESE | CSAPGEQPKF | LGIREQRVTG | LMIFVLMGCS | VFMTAVLKFI | 
    950:
    PMPVLYGVFL | YMGVSSLQGI | QFFDRLKLFG | MPAKHQPDFI | YLRHVPLRKV | 
    1000:
    HLFTLVQLTC | LVLLWVIKAS | PAAIVFPMMV | LALVFVRKVM | DLCFSKRELS | 
    1050:
    WLDDLMPESK | KKKLDDAKKK | EEEEAEKMLD | IGGDKFPLES | RKLLSSPGKS | 
    1089:
    SSFRCDPSEI | NISDEMPKTT | VWKALSINSG | NTKEKSPFN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    SMR:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Electroneutral sodium bicarbonate exchanger 1
    ELISA Kit for Mouse Electroneutral sodium bicarbonate exchanger 1
    ELISA Kit for Mouse Electroneutral sodium bicarbonate exchanger 1
    CLIA Kit for Mouse Electroneutral sodium bicarbonate exchanger 1
    CLIA Kit for Mouse Electroneutral sodium bicarbonate exchanger 1
    CLIA Kit for Mouse Electroneutral sodium bicarbonate exchanger 1
    Polyclonal Antibody for Mouse Electroneutral sodium bicarbonate exchanger 1
    Polyclonal Antibody for Mouse Electroneutral sodium bicarbonate exchanger 1
    Polyclonal Antibody for Mouse Electroneutral sodium bicarbonate exchanger 1
    Monoclonal Antibody for Mouse Electroneutral sodium bicarbonate exchanger 1
    Monoclonal Antibody for Mouse Electroneutral sodium bicarbonate exchanger 1
    Monoclonal Antibody for Mouse Electroneutral sodium bicarbonate exchanger 1
    Protein for Mouse Electroneutral sodium bicarbonate exchanger 1
    Protein for Mouse Electroneutral sodium bicarbonate exchanger 1
    Protein for Mouse Electroneutral sodium bicarbonate exchanger 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mouse Na+: HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution."
      Wang Z. , Conforti L. , Petrovic S. , Amlal H. , Burnham C.E. , Soleimani M.
      Kidney Int.59:1405-1414(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INHIBITION
      tissue: Kidney inner medulla.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Dendritic cell.
      tissue: Spinal cord.
    3. 3.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Seino S. , Nishimura M. , Kaisho T. , Hoshino K. , Kitamura H. , Nagase T. , Ohara O. , Koga H.
      DNA Res.11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Fetal brain.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Retina.
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