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Index > Protein center > Uba2(Gene name) > Mouse
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  • Uba2 (Gene name),
  • SUMO-activating enzyme subunit 2 (Protein name ),  SAE2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Uba2(Sae2;Uble1b);
    Protein name:
    SUMO-activating enzyme subunit 2;
    Alternative:
    Ubiquitin-like 1-activating enzyme E1B;Anthracycline-associated resistance ARX;Ubiquitin-like modifier-activating enzyme 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
    Function:
    The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    638
    Sequence:
    50:
    MALSRGLPRE | LAEAVSGGRV | LVVGAGGIGC | ELLKNLVLTG | FSHIDLIDLD | 
    100:
    TIDVSNLNRQ | FLFQKKHVGR | SKAQVAKESV | LQFHPQANIE | AHHDSIMNPD | 
    150:
    YNVEFFRQFI | LVMNALDNRA | ARNHVNRMCL | AADVPLIESG | TAGYLGQVTT | 
    200:
    IKKGVTECYE | CHPKPTQRTF | PGCTIRNTPS | EPIHCIVWAK | YLFNQLFGEE | 
    250:
    DADQEVSPDR | ADPEAAWEPT | EAEARARASN | EDGDIKRIST | KEWAKSTGYD | 
    300:
    PVKLFTKLFK | DDIRYLLTMD | KLWRKRKPPV | PLDWAEVQSQ | GEANADQQNE | 
    350:
    PQLGLKDQQV | LDVKSYASLF | SKSIETLRVH | LAEKGDGAEL | IWDKDDPPAM | 
    400:
    DFVTSAANLR | MHIFSMNMKS | RFDIKSMAGN | IIPAIATTNA | VIAGLIVLEG | 
    450:
    LKILSGKIDQ | CRTIFLNKQP | NPRKKLLVPC | ALDPPNTNCY | VCASKPEVTV | 
    500:
    RLNVHKVTVL | TLQDKIVKEK | FAMVAPDVQI | EDGKGTILIS | SEEGETEANN | 
    550:
    PKKLSDFGIR | NGSRLQADDF | LQDYTLLINI | LHSEDLGKDV | EFEVVGDSPE | 
    600:
    KVGPKQAEDA | AKSIANGSDD | GAQPSTSTAQ | EQDDVLIVDS | DEEGPSNSTD | 
    638:
    CSGDDKARKR | KLEENEAAST | KKCRLEQMED | PDDVIALD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SUMO-activating enzyme subunit 2
    ELISA Kit for Mouse SUMO-activating enzyme subunit 2
    CLIA Kit for Mouse SUMO-activating enzyme subunit 2
    CLIA Kit for Mouse SUMO-activating enzyme subunit 2
    Polyclonal Antibody for Mouse SUMO-activating enzyme subunit 2
    Polyclonal Antibody for Mouse SUMO-activating enzyme subunit 2
    Monoclonal Antibody for Mouse SUMO-activating enzyme subunit 2
    Monoclonal Antibody for Mouse SUMO-activating enzyme subunit 2
    Protein for Mouse SUMO-activating enzyme subunit 2
    Protein for Mouse SUMO-activating enzyme subunit 2

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      Mizunuma N. , Terashima M. , Yamauchi T. , Kufe D.W. , Slapak C.A.
      Submitted (1995-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: DBA/2J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Amnion.
      tissue: Bone marrow.
      tissue: Corpora quadrigemina.
      tissue: Head.
      tissue: Kidney.
      tissue: Lung.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      "Expression and regulation of the mammalian SUMO-1 E1 enzyme."
      Azuma Y. , Tan S.-H. , Cavenagh M.M. , Ainsztein A.M. , Saitoh H. , Dasso M.
      FASEB J.15:1825-1827(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;TISSUE SPECIFICITY
    5. 5.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-271 AND LYS-611;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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