SAM domain-containing protein SAMSN-1 (Protein name
), SAMN1_MOUSE from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
Samsn1;
Protein name:
SAM domain-containing protein SAMSN-1;
Alternative:
SH3 protein expressed in lymphocytes 2;SAM domain, SH3 domain and nuclear localization signals protein 1;SH3-lymphocyte protein 2(SLy2);
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with FASLG (By similarity). Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1.
Function:
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
Subcellular Location:
Nucleus
Cytoplasm
Cell projection
ruffle
Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.
"SLy: a novel family of putative adaptor proteins in lymphocytes." von Holleben M.
,
Kloeter S.
,
Beer S.
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]
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Cited for: FUNCTION;INDUCTION BY IL4 AND LIPOPOLYSACCHARIDE;SUBCELLULAR LOCATION;SUBUNIT;INTERACTION WITH TYROSINE PHOSPHORYLATED PROTEINS;TISSUE SPECIFICITY
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-160;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-23;INTERACTION WITH SAP30; HDAC1; YWHAB; YWHAE; YWHAG; YWHAH; YWHAZ AND SFN;SUBUNIT;MUTAGENESIS OF SER-23
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CTTN
Vaild Sequence:
