Squamous cell carcinoma antigen recognized by T-cells 3 (Protein name
), SART3_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
SART3(KIAA0156;TIP110);
Protein name:
Squamous cell carcinoma antigen recognized by T-cells 3(SART-3;hSART-3);
Alternative:
Tat-interacting protein of 110 kDa(Tip110);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with HIV-1 Tat. Interacts with EIF2C1 and EIF2C2.
Function:
Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.
Subcellular Location:
Cytoplasm
Nucleus speckle
Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;FUNCTION;INTERACTION WITH TAT;REGION
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-23
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
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Cited for: FUNCTION (ISOFORM 2);INTERACTION WITH PRPF3;REGION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PROTEIN SEQUENCE OF 2-17; 121-130; 233-243; 295-322; 329-335; 350-356; 360-370; 452-463; 494-502; 555-568; 646-669; 758-768 AND 911-918;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;INTERACTION WITH PRPF3 AND USP4;REGION
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;INTERACTION WITH USP15
25.
"Solution structure of the RNA binding domain of squamous cell carcinoma antigen recognized by T cells 3." RIKEN structural genomics initiative (RSGI)
Submitted (2007-04) to the PDB data bank
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Cited for: STRUCTURE BY NMR OF 791-877
Vaild Sequence:
