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Index > Protein center > Slc5a8(Gene name) > Mouse
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  • Slc5a8 (Gene name),
  • Sodium-coupled monocarboxylate transporter 1 (Protein name ),  SC5A8_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Slc5a8(Smct;Smct1);
    Protein name:
    Sodium-coupled monocarboxylate transporter 1;
    Alternative:
    Solute carrier family 5 member 8;Electrogenic sodium monocarboxylate cotransporter;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
    Subcellular Location:
    Membrane Multi-pass membrane protein Apical cell membrane Multi-pass membrane protein Restricted to the apical cell membrane of enterocytes.
    Protein Attributes:
    Sequence length:
    611
    Sequence:
    50:
    MDASRDIGSF | VVWDYVVFAG | MLLISAAIGI | YYAFAGGGQQ | TSKDFLMGGR | 
    100:
    SMSAVPVALS | LTASFMSAVT | VLGTPAEVYR | FGAIFSIFVI | TYFFVVVISA | 
    150:
    EVFLPVFYRL | GITSTYEYLE | LRFNRCIRLC | GTILFIVQTI | LYTGIVIYAP | 
    200:
    ALALNQVTGF | DLWGAVVATG | VVCTFYCTLG | GLKAVVWTDV | FQVGIMVAGF | 
    250:
    ASVIIQASIT | QHGINKILSD | AFNGGRLNFW | NFDPNPLQRH | TFWTIVIGGT | 
    300:
    FTWTTIYGVN | QSQVQRYISC | KSRLHAKLSL | YVNLVGLWVI | LTCSIFCGLA | 
    350:
    LYSRYRECDP | WTSKKVSAID | QLMPYLVLDI | LKNYPGVPGL | FVACAYSGTL | 
    400:
    STVSSSINAL | AAVTVEDLIK | PRFKSLSEKS | LSWISQGMSV | LYGALCIGMA | 
    450:
    ALASLMGALL | QAALSIFGMV | GGPLLGLFSL | GILVPFANSI | GALTGLLAGF | 
    500:
    AISLWVGIGA | QLYPPLPERT | LPLPLETYGC | NITHNGSDWM | STTEMPFSTS | 
    550:
    AFQIHNAERT | PLMDNWYSLS | YLYFSTIGTL | TTLFVGILIS | LSTGGRKQNL | 
    600:
    DPRFLLTKQD | FLSNFDVFKK | RNHVLNYKLH | PVEVGGTDNP | AFNHVELNFT | 
    611:
    DHSGKINGTR | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Sodium-coupled monocarboxylate transporter 1
    ELISA Kit for Mouse Sodium-coupled monocarboxylate transporter 1
    CLIA Kit for Mouse Sodium-coupled monocarboxylate transporter 1
    CLIA Kit for Mouse Sodium-coupled monocarboxylate transporter 1
    Polyclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 1
    Polyclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 1
    Monoclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 1
    Monoclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 1
    Protein for Mouse Sodium-coupled monocarboxylate transporter 1
    Protein for Mouse Sodium-coupled monocarboxylate transporter 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate."
      Gopal E. , Fei Y.-J. , Sugawara M. , Miyauchi S. , Zhuang L. , Martin P. , Smith S.B. , Prasad P.D. , Ganapathy V.
      J. Biol. Chem.279:44522-44532(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;STOICHIOMETRY;STIMULATION;INHIBITION;TISSUE SPECIFICITY
      strain: C57BL/6.
      tissue: Kidney.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Kidney.
    4. 4.
      "Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family."
      Gopal E. , Fei Y.J. , Miyauchi S. , Zhuang L. , Prasad P.D. , Ganapathy V.
      Biochem. J.388:309-316(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
    5. 5.
      "Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8."
      Hong C. , Maunakea A. , Jun P. , Bollen A.W. , Hodgson J.G. , Goldenberg D.D. , Weiss W.A. , Costello J.F.
      Cancer Res.65:3617-3623(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    6. 6.
      "Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8."
      Iwanaga T. , Takebe K. , Kato I. , Karaki S. , Kuwahara A.
      Biomed. Res.27:243-254(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    7. 7.
      "Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain."
      Martin P.M. , Gopal E. , Ananth S. , Zhuang L. , Itagaki S. , Prasad B.M. , Smith S.B. , Prasad P.D. , Ganapathy V.
      J. Neurochem.98:279-288(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    8. 8.
      "Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract."
      Gopal E. , Miyauchi S. , Martin P.M. , Ananth S. , Roon P. , Smith S.B. , Ganapathy V.
      Pharm. Res.24:575-584(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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