Gene name:
    SLC5A11 (KST1;SLGTX;SMIT2) ;
    
 
    Protein name:
    Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) ;
    
    Alternative:
    
    Sodium/glucose cotransporter KST1 ;Sodium-dependent glucose cotransporter ;Solute carrier family 5 member 11 ;Solute carrier family 5 member 11 (SMIT2) ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Function:
    Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Membrane  
      Multi-pass membrane protein 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MESGTSSPQP |  PQLDPLDAFP |  QKGLEPGDIA |  VLVLYFLFVL |  AVGLWSTVKT |  
    
 
    100:
    KRDTVKGYFL |  AGGDMVWWPV |  GASLFASNVG |  SGHFIGLAGS |  GAATGISVSA |  
    
 
    150:
    YELNGLFSVL |  MLAWIFLPIY |  IAGQVTTMPE |  YLRKRFGGIR |  IPIILAVLYL |  
    
 
    200:
    FIYIFTKISV |  DMYAGAIFIQ |  QSLHLDLYLA |  IVGLLAITAV |  YTVAGGLAAV |  
    
 
    250:
    IYTDALQTLI |  MLIGALTLMG |  YSFAAVGGME |  GLKEKYFLAL |  ASNRSENSSC |  
    
 
    300:
    GLPREDAFHI |  FRDPLTSDLP |  WPGVLFGMSI |  PSLWYWCTDQ |  VIVQRTLAAK |  
    
 
    350:
    NLSHAKGGAL |  MAAYLKVLPL |  FIMVFPGMVS |  RILFPDQVAC |  ADPEICQKIC |  
    
 
    400:
    SNPSGCSDIA |  YPKLVLELLP |  TGLRGLMMAV |  MVAALMSSLT |  SIFNSASTIF |  
    
 
    450:
    TMDLWNHLRP |  RASEKELMIV |  GRVFVLLLVL |  VSILWIPVVQ |  ASQGGQLFIY |  
    
 
    500:
    IQSISSYLQP |  PVAVVFIMGC |  FWKRTNEKGA |  FWGLISGLLL |  GLVRLVLDFI |  
    
 
    550:
    YVQPRCDQPD |  ERPVLVKSIH |  YLYFSMILST |  VTLITVSTVS |  WFTEPPSKEM |  
    
 
    600:
    VSHLTWFTRH |  DPVVQKEQAP |  PAAPLSLTLS |  QNGMPEASSS |  SSVQFEMVQE |  
    
 
    650:
    NTSKTHSCDM |  TPKQSKVVKA |  ILWLCGIQEK |  GKEELPARAE |  AIIVSLEENP |  
    
 
    675:
    LVKTLLDVNL |  IFCVSCAIFI |  WGYFA
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Rat
         
        
        Pig
         
        
        Human
         
        
        Rabbit
         
        
        Mouse
         
        
        Bovine
         
        
     
    
        ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Protein for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Protein for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Protein for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Protein for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Protein for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
    
        Protein for Human Na(+)/myo-inositol cotransporter 2
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;VARIANTS ALA-182; LEU-258 AND ILE-526 
                    
                    
                    tissue :
                    
Brain .  
             
         
            
        
            
                2.
                
                    
                        
                            "Cloning of the human ortholog of RKST1, a member of the SGLT gene family of sodium-coupled cotransporters." 
                        
                        
                            Mount D.B. 
                        
                        
                        
                            Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-182 
                    
                    
                 
             
         
            
        
            
                3.
                
                    
                        
                            "Cloning and functional characterization of a new human sugar transporter in kidney." 
                        
                        
                            Bruss M. 
                        ,
                            
Bonisch H. 
                        
                        
                        
                            Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Kidney .  
             
         
            
        
            
                4.
                
                    
                        
                            "Complete sequencing and characterization of 21,243 full-length human cDNAs." 
                        
                        
                            Ota T. 
                        ,
                            
Suzuki Y. 
                        ,
                            
Nishikawa T. 
                        ,
                            
Otsuki T. 
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                            Nat. Genet.36:40-45(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5);VARIANT ALA-182 
                    
                    
                    tissue :
                    
Corpus callosum . tissue :
                    
Kidney .  
             
         
            
        
            
                5.
                
                    
                        
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                              more...   
                             
                        
                        
                        
                            Nature432:988-994(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                        
                        
                            Mural R.J. 
                        ,
                            
Istrail S. 
                        ,
                            
Sutton G.G. 
                        ,
                            
Florea L. 
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Mobarry C.M. 
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                            Venter J.C. 
                        
                             
                              more...   
                             
                        
                        
                            Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 6);VARIANT ARG-452 
                    
                    
                    tissue :
                    
Brain . tissue :
                    
Hypothalamus .  
             
         
            
        
            
                8.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;VARIANT ALA-182 
                    
                    
                 
             
         
            
        
            
                9.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for POSSIBLE ROLE IN SLE