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Index > Protein center > SLC5A11(Gene name) > Human
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  • SLC5A11 (Gene name),
  • Sodium/myo-inositol cotransporter 2 (Protein name ),  SC5AB_HUMAN from NCBI database.
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  • Gene name:
    SLC5A11(KST1;SLGTX;SMIT2);
    Protein name:
    Sodium/myo-inositol cotransporter 2(Na(+)/myo-inositol cotransporter 2);
    Alternative:
    Sodium/glucose cotransporter KST1;Sodium-dependent glucose cotransporter;Solute carrier family 5 member 11;Solute carrier family 5 member 11(SMIT2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    675
    Sequence:
    50:
    MESGTSSPQP | PQLDPLDAFP | QKGLEPGDIA | VLVLYFLFVL | AVGLWSTVKT | 
    100:
    KRDTVKGYFL | AGGDMVWWPV | GASLFASNVG | SGHFIGLAGS | GAATGISVSA | 
    150:
    YELNGLFSVL | MLAWIFLPIY | IAGQVTTMPE | YLRKRFGGIR | IPIILAVLYL | 
    200:
    FIYIFTKISV | DMYAGAIFIQ | QSLHLDLYLA | IVGLLAITAV | YTVAGGLAAV | 
    250:
    IYTDALQTLI | MLIGALTLMG | YSFAAVGGME | GLKEKYFLAL | ASNRSENSSC | 
    300:
    GLPREDAFHI | FRDPLTSDLP | WPGVLFGMSI | PSLWYWCTDQ | VIVQRTLAAK | 
    350:
    NLSHAKGGAL | MAAYLKVLPL | FIMVFPGMVS | RILFPDQVAC | ADPEICQKIC | 
    400:
    SNPSGCSDIA | YPKLVLELLP | TGLRGLMMAV | MVAALMSSLT | SIFNSASTIF | 
    450:
    TMDLWNHLRP | RASEKELMIV | GRVFVLLLVL | VSILWIPVVQ | ASQGGQLFIY | 
    500:
    IQSISSYLQP | PVAVVFIMGC | FWKRTNEKGA | FWGLISGLLL | GLVRLVLDFI | 
    550:
    YVQPRCDQPD | ERPVLVKSIH | YLYFSMILST | VTLITVSTVS | WFTEPPSKEM | 
    600:
    VSHLTWFTRH | DPVVQKEQAP | PAAPLSLTLS | QNGMPEASSS | SSVQFEMVQE | 
    650:
    NTSKTHSCDM | TPKQSKVVKA | ILWLCGIQEK | GKEELPARAE | AIIVSLEENP | 
    675:
    LVKTLLDVNL | IFCVSCAIFI | WGYFA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
    ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
    ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
    ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
    ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
    ELISA Kit for Human Na(+)/myo-inositol cotransporter 2
    CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
    CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
    CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
    CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
    CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
    CLIA Kit for Human Na(+)/myo-inositol cotransporter 2
    Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Polyclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Monoclonal Antibody for Human Na(+)/myo-inositol cotransporter 2
    Protein for Human Na(+)/myo-inositol cotransporter 2
    Protein for Human Na(+)/myo-inositol cotransporter 2
    Protein for Human Na(+)/myo-inositol cotransporter 2
    Protein for Human Na(+)/myo-inositol cotransporter 2
    Protein for Human Na(+)/myo-inositol cotransporter 2
    Protein for Human Na(+)/myo-inositol cotransporter 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families."
      Roll P. , Massacrier A. , Pereira S. , Robaglia-Schlupp A. , Cau P. , Szepetowski P.
      Gene285:141-148(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;VARIANTS ALA-182; LEU-258 AND ILE-526
      tissue: Brain.
    2. 2.
      "Cloning of the human ortholog of RKST1, a member of the SGLT gene family of sodium-coupled cotransporters."
      Mount D.B.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-182
    3. 3.
      "Cloning and functional characterization of a new human sugar transporter in kidney."
      Bruss M. , Bonisch H.
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Kidney.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5);VARIANT ALA-182
      tissue: Corpus callosum.
      tissue: Kidney.
    5. 5.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 6);VARIANT ARG-452
      tissue: Brain.
      tissue: Hypothalamus.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANT ALA-182
    9. 9.
      "The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modifier gene in SLE."
      Tsai L.-J. , Hsiao S.-H. , Tsai L.-M. , Lin C.-Y. , Tsai J.-J. , Liou D.-M. , Lan J.-L.
      Tissue Antigens71:114-126(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE ROLE IN SLE
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