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Index > Protein center > Scn1a(Gene name) > Rat
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  • Scn1a (Gene name),
  • Sodium channel protein type 1 subunit alpha (Protein name ),  SCN1A_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Scn1a;
    Protein name:
    Sodium channel protein type 1 subunit alpha;
    Alternative:
    Sodium channel protein type I subunit alpha;Sodium channel protein brain I subunit alpha;Voltage-gated sodium channel subunit alpha Nav1.1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide.
    Function:
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    2009
    Sequence:
    50:
    MEQTVLVPPG | PDSFNFFTRE | SLAAIERRIA | EEKAKNPKPD | KKDDDENGPK | 
    100:
    PNSDLEAGKN | LPFIYGDIPP | EMVSEPLEDL | DPYYINKKTF | IVLNKGKAIF | 
    150:
    RFSATSALYI | LTPFNPLRKI | AIKILVHSLF | SMLIMCTILT | NCVFMTMSNP | 
    200:
    PDWTKNVEYT | FTGIYTFESL | IKIIARGFCL | EDFTFLRDPW | NWLDFTVITF | 
    250:
    AYVTEFVDLG | NVSALRTFRV | LRALKTISVI | PGLKTIVGAL | IQSVKKLSDV | 
    300:
    MILTVFCLSV | FALIGLQLFM | GNLRNKCVQW | PPTNASLEEH | SIEKNVTTDY | 
    350:
    NGTLVNETVF | EFDWKSYIQD | SRYHYFLEGV | LDALLCGNSS | DAGQCPEGYM | 
    400:
    CVKAGRNPNY | GYTSFDTFSW | AFLSLFRLMT | QDFWENLYQL | TLRAAGKTYM | 
    450:
    IFFVLVIFLG | SFYLINLILA | VVAMAYEEQN | QATLEEAEQK | EAEFQQMLEQ | 
    500:
    LKKQQEAAQQ | AAAATASEHS | REPSAAGRLS | DSSSEASKLS | SKSAKERRNR | 
    550:
    RKKRKQKEQS | GGEEKDDDEF | HKSESEDSIR | RKGFRFSIEG | NRLTYEKRYS | 
    600:
    SPHQSLLSIR | GSLFSPRRNS | RTSLFSFRGR | AKDVGSENDF | ADDEHSTFED | 
    650:
    NESRRDSLFV | PRRHGERRNS | NLSQTSRSSR | MLAGLPANGK | MHSTVDCNGV | 
    700:
    VSLVGGPSVP | TSPVGQLLPE | VIIDKPATDD | NGTTTETEMR | KRRSSSFHVS | 
    750:
    MDFLEDPSQR | QRAMSIASIL | TNTVEELEES | RQKCPPCWYK | FSNIFLIWDC | 
    800:
    SPYWLKVKHI | VNLVVMDPFV | DLAITICIVL | NTLFMAMEHY | PMTEHFNHVL | 
    850:
    TVGNLVFTGI | FTAEMFLKII | AMDPYYYFQE | GWNIFDGFIV | TLSLVELGLA | 
    900:
    NVEGLSVLRS | FRLLRVFKLA | KSWPTLNMLI | KIIGNSVGAL | GNLTLVLAII | 
    950:
    VFIFAVVGMQ | LFGKSYKDCV | CKIATDCKLP | RWHMNDFFHS | FLIVFRVLCG | 
    1000:
    EWIETMWDCM | EVAGQAMCLT | VFMMVMVIRN | LVVLNLFLAL | LLSSFSADNL | 
    1050:
    AATDDDNEMN | NLQIAVDRMH | KGVAYVKRKI | YEFIQQSFVR | KQKILDEIKP | 
    1100:
    LDDLNNRKDN | CTSNHTTEIG | KDLDCLKDVN | GTTSGIGTGS | SVEKYIIDES | 
    1150:
    DYMSFINNPS | LTVTVPIAVG | ESDFENLNTE | DFSSESDLEE | SKEKLNESSS | 
    1200:
    SSEGSTVDIG | APAEEQPVME | PEETLEPEAC | FTEGCVQRFK | CCQISVEEGR | 
    1250:
    GKQWWNLRRT | CFRIVEHNWF | ETFIVFMILL | SSGALAFEDI | YIDQRKTIKT | 
    1300:
    MLEYADKVFT | YIFILEMLLK | WVAYGYQTYF | TNAWCWLDFL | IVDVSLVSLT | 
    1350:
    ANALGYSELG | AIKSLRTLRA | LRPLRALSRF | EGMRVVVNAL | LGAIPSIMNV | 
    1400:
    LLVCLIFWLI | FSIMGVNLFA | GKFYHCVNTT | TGDTFEITEV | NNHSDCLKLI | 
    1450:
    ERNETARWKN | VKVNFDNVGF | GYLSLLQVAT | FKGWMDIMYA | AVDSRNVELQ | 
    1500:
    PKYEESLYMY | LYFVIFIIFG | SFFTLNLFIG | VIIDNFNQQK | KKFGGQDIFM | 
    1550:
    TEEQKKYYNA | MKKLGSKKPQ | KPIPRPGNKF | QGMVFDFVTR | QVFDISIMIL | 
    1600:
    ICLNMVTMMV | ETDDQSDYVT | SILSRINLVF | IVLFTGECVL | KLISLRHYYF | 
    1650:
    TIGWNIFDFV | VVILSIVGMF | LAELIEKYFV | SPTLFRVIRL | ARIGRILRLI | 
    1700:
    KGAKGIRTLL | FALMMSLPAL | FNIGLLLFLV | MFIYAIFGMS | NFAYVKREVG | 
    1750:
    IDDMFNFETF | GNSMICLFQI | TTSAGWDGLL | APILNSKPPD | CDPNKVNPGS | 
    1800:
    SVKGDCGNPS | VGIFFFVSYI | IISFLVVVNM | YIAVILENFS | VATEESAEPL | 
    1850:
    SEDDFEMFYE | VWEKFDPDAT | QFMEFEKLSQ | FAAALEPPLN | LPQPNKLQLI | 
    1900:
    AMDLPMVSGD | RIHCLDILFA | FTKRVLGESG | EMDALRIQME | ERFMASNPSK | 
    1950:
    VSYQPITTTL | KRKQEEVSAV | IIQRAYRRHL | LKRTVKQASF | TYNKNKLKGG | 
    2000:
    ANLLVKEDMI | IDRINENSIT | EKTDLTMSTA | ACPPSYDRVT | KPIVEKHEQE | 
    2009:
    GKDEKAKGK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Sodium channel protein type 1 subunit alpha
    ELISA Kit for Rat Sodium channel protein type 1 subunit alpha
    CLIA Kit for Rat Sodium channel protein type 1 subunit alpha
    CLIA Kit for Rat Sodium channel protein type 1 subunit alpha
    Polyclonal Antibody for Rat Sodium channel protein type 1 subunit alpha
    Polyclonal Antibody for Rat Sodium channel protein type 1 subunit alpha
    Monoclonal Antibody for Rat Sodium channel protein type 1 subunit alpha
    Monoclonal Antibody for Rat Sodium channel protein type 1 subunit alpha
    Protein for Rat Sodium channel protein type 1 subunit alpha
    Protein for Rat Sodium channel protein type 1 subunit alpha

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Existence of distinct sodium channel messenger RNAs in rat brain."
      Noda M. , Ikeda T. , Kayano T. , Suzuki H. , Takeshima H. , Kurasaki M. , Takahashi H. , Numa S.
      Nature320:188-192(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Structure and function of sodium channel."
      Noda M. , Numa S.
      J. Recept. Res.7:467-497(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs."
      Sarao R. , Gupta S.K. , Auld V.J. , Dunn R.J.
      Nucleic Acids Res.19:5673-5679(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 177-253
      strain: Sprague-Dawley.
      tissue: Brain.
    4. 4.
      "Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain."
      Berendt F.J. , Park K.S. , Trimmer J.S.
      J. Proteome Res.9:1976-1984(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-470; SER-551 AND SER-607
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