SCN4B ELISA Kit for Human(Homo sapiens) | EIAab.comSCN4B ELISA Kit for Human(Homo sapiens)

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SCN4B (Gene name),

Sodium channel subunit beta-4 (Protein name ), SCN4B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SCN4B;

Protein name:

Sodium channel subunit beta-4;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Associates with SCN2A.

Function:

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

228

Sequence:

50:

100:

150:

200:

228:

CLVSSSGNDN | TENGLPGSKA | EEKPPSKV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07686

String:

Q8IWT1

UniGene:

Hs.65239

KEGG:

hsa:6330

MIM:

608256

STRING:

9606.ENSP00000322460

SMR:

Q8IWT1

Uniprot:

Q8IWT1

FOR

ELISA Kit for Human Sodium channel subunit beta-4

CLIA Kit for Human Sodium channel subunit beta-4

Polyclonal Antibody for Human Sodium channel subunit beta-4

Monoclonal Antibody for Human Sodium channel subunit beta-4

Protein for Human Sodium channel subunit beta-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2."
Yu F.H. , Westenbroek R.E. , Silos-Santiago I. , McCormick K.A. , Lawson D. , Ge P. , Ferriera H. , Lilly J. , DiStefano P.S. , Catterall W.A. , Scheuer T. , Curtis R.
J. Neurosci.23:7577-7585(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Brain.
2.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
4.

"Crystallographic insights into sodium-channel modulation by the beta4 subunit."
Gilchrist J. , Das S. , Van Petegem F. , Bosmans F.
Proc. Natl. Acad. Sci. U.S.A.110:E5016-E5024(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 32-157;FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;DISULFIDE BOND;GLYCOSYLATION;INTERACTION WITH SCN2A;MUTAGENESIS OF CYS-58 AND CYS-131
5.

"SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome."
Medeiros-Domingo A. , Kaku T. , Tester D.J. , Iturralde-Torres P. , Itty A. , Ye B. , Valdivia C. , Ueda K. , Canizales-Quinteros S. , Tusie-Luna M.T. , Makielski J.C. , Ackerman M.J.
Circulation116:134-142(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LQT10 PHE-179;CHARACTERIZATION OF VARIANT LQT10 PHE-179
6.

"Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation."
Olesen M.S. , Jespersen T. , Nielsen J.B. , Liang B. , Moller D.V. , Hedley P. , Christiansen M. , Varro A. , Olesen S.P. , Haunso S. , Schmitt N. , Svendsen J.H.
Cardiovasc. Res.89:786-793(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"Mutations of the SCN4B-encoded sodium channel beta4 subunit in familial atrial fibrillation."
Li R.G. , Wang Q. , Xu Y.J. , Zhang M. , Qu X.K. , Liu X. , Fang W.Y. , Yang Y.Q.
Int. J. Mol. Med.32:144-150(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ATFB17;VARIANTS ATFB17 GLY-162 AND LEU-166

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