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Index > Protein center > Scnn1g(Gene name) > Rat
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  • Scnn1g (Gene name),
  • Amiloride-sensitive sodium channel subunit gamma (Protein name ),  SCNNG_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Scnn1g;
    Protein name:
    Amiloride-sensitive sodium channel subunit gamma;
    Alternative:
    Gamma-NaCH;Epithelial Na(+) channel subunit gamma(Gamma-ENaC);SCNEG;Nonvoltage-gated sodium channel 1 subunit gamma;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.
    Function:
    Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
    Subcellular Location:
    Apical cell membrane Multi-pass membrane protein Apical membrane of epithelial cells.
    Protein Attributes:
    Sequence length:
    650
    Sequence:
    50:
    MAPGEKIKAK | IKKNLPVRGP | QAPTIKDLMH | WYCMNTNTHG | CRRIVVSRGR | 
    100:
    LRRLLWIAFT | LTAVALIIWQ | CALLVFSFYT | VSVSIKVHFQ | KLDFPAVTIC | 
    150:
    NINPYKYSAV | SDLLTDLDSE | TKQALLSLYG | VKESRKRREA | GSMPSTLEGT | 
    200:
    PPRFFKLIPL | LVFNENEKGK | ARDFFTGRKR | KISGKIIHKA | SNVMHVHESK | 
    250:
    KLVGFQLCSN | DTSDCATYTF | SSGINAIQEW | YKLHYMNIMA | QVPLEKKINM | 
    300:
    SYSAEELLVT | CFFDGMSCDA | RNFTLFHHPM | YGNCYTFNNK | ENATILSTSM | 
    350:
    GGSEYGLQVI | LYINEDEYNP | FLVSSTGAKV | LIHQQNEYPF | IEDVGMEIET | 
    400:
    AMSTSIGMHL | TESFKLSEPY | SQCTEDGSDV | PVTNIYNAAY | SLQICLYSCF | 
    450:
    QTKMVEKCGC | AQYSQPLPPA | ANYCNYQQHP | NWMYCYYQLY | QAFVREELGC | 
    500:
    QSVCKQSCSF | KEWTLTTSLA | QWPSEASEKW | LLNVLTWDQS | QQINKKLNKT | 
    550:
    DLAKLLIFYK | DLNQRSIMES | PANSIEMLLS | NFGGQLGLWM | SCSVVCVIEI | 
    600:
    IEVFFIDFFS | IIARRQWHKA | KDWWARRQTP | PSTETPSSRQ | GQDNPALDTD | 
    650:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Amiloride-sensitive sodium channel subunit gamma
    ELISA Kit for Rat Amiloride-sensitive sodium channel subunit gamma
    ELISA Kit for Rat Amiloride-sensitive sodium channel subunit gamma
    ELISA Kit for Rat Amiloride-sensitive sodium channel subunit gamma
    CLIA Kit for Rat Amiloride-sensitive sodium channel subunit gamma
    CLIA Kit for Rat Amiloride-sensitive sodium channel subunit gamma
    CLIA Kit for Rat Amiloride-sensitive sodium channel subunit gamma
    CLIA Kit for Rat Amiloride-sensitive sodium channel subunit gamma
    Polyclonal Antibody for Rat Amiloride-sensitive sodium channel subunit gamma
    Polyclonal Antibody for Rat Amiloride-sensitive sodium channel subunit gamma
    Polyclonal Antibody for Rat Amiloride-sensitive sodium channel subunit gamma
    Polyclonal Antibody for Rat Amiloride-sensitive sodium channel subunit gamma
    Monoclonal Antibody for Rat Amiloride-sensitive sodium channel subunit gamma
    Monoclonal Antibody for Rat Amiloride-sensitive sodium channel subunit gamma
    Monoclonal Antibody for Rat Amiloride-sensitive sodium channel subunit gamma
    Monoclonal Antibody for Rat Amiloride-sensitive sodium channel subunit gamma
    Protein for Rat Amiloride-sensitive sodium channel subunit gamma
    Protein for Rat Amiloride-sensitive sodium channel subunit gamma
    Protein for Rat Amiloride-sensitive sodium channel subunit gamma
    Protein for Rat Amiloride-sensitive sodium channel subunit gamma

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits."
      Canessa C.M. , Schild L. , Buell G. , Thorens B. , Gautschi I. , Horisberger J.-D. , Rossier B.C.
      Nature367:463-467(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Distal colon epithelium.
    2. 2.
      "Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone."
      Lingueglia R. , Renard S. , Waldmann R. , Voilley N. , Champigny G. , Plass H. , Lazdunski M. , Barbry P.
      J. Biol. Chem.269:13736-13739(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Wistar.
      tissue: Distal colon.
    3. 3.
      "Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension."
      Kreutz R. , Struk B. , Rubattu S. , Hubner N. , Szpirer J. , Szpirer C. , Ganten D. , Lindpaintner K.
      Hypertension29:131-136(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Distal colon.
      tissue: Kidney.
    4. 4.
      "Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination."
      Staub O. , Gautschi I. , Ishikawa T. , Breitschopf K. , Ciechanover A. , Schild L. , Rotin D.
      EMBO J.16:6325-6336(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LYS-6 AND LYS-13;UBIQUITINATION
    5. 5.
      "In vivo phosphorylation of the epithelial sodium channel."
      Shimkets R.A. , Lifton R. , Canessa C.M.
      Proc. Natl. Acad. Sci. U.S.A.95:3301-3305(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    6. 6.
      "Solution structure of a Nedd4 WW domain-ENaC peptide complex."
      Kanelis V. , Rotin D. , Forman-Kay J.D.
      Nat. Struct. Biol.8:407-412(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEDD4
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