Stromal cell-derived factor 1 (Protein name
), SDF1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
CXCL12(SDF1;SDF1A;SDF1B);
Protein name:
Stromal cell-derived factor 1(SDF-1;hSDF-1);
Alternative:
Intercrine reduced in hepatomas(IRH;hIRH);C-X-C motif chemokine 12;Pre-B cell growth-stimulating factor(PBSF);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
N/A
Function:
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS GAMMA; DELTA; EPSILON AND THETA);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;ALTERNATIVE SPLICING
"Inhibition of X4 and R5 HIV-1 by human SDF-1g, a novel chemokine that interferes with HIV transcription." Callebaut C.
,
Verdin E.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GAMMA)
6.
"Polymorphism study of cell-derived factor 1 (SDF1) gene and their correlation with HIV infection in a Chinese cohort." Zhao X.
,
Zhang H.
,
Lee S.
,
Wong K.
,
Zheng B.
Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
7.
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L.
,
Schick M.
,
Neubert P.
,
Schatten R.
,
Henze S.
,
Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND BETA)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
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Cited for: INTERACTION WITH HEPARAN SULFATE;MUTAGENESIS OF 45-LYS--LYS-48
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Cited for: IDENTIFICATION OF SDF-1ALPHA(3-67) AND SDF-1BETA(3-72) BY MASS SPECTROMETRY;PROTEOLYTIC PROCESSING OF N-TERMINUS AND C-TERMINUS
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Cited for: STRUCTURE BY NMR OF 22-88;DISULFIDE BONDS;MUTAGENESIS OF LYS-22; PRO-23; 22-LYS-PRO-23; 25-SER--SER-27; TYR-28 AND ARG-29
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Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 22-88 OF MUTANT ALA-54;DISULFIDE BONDS
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Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 22-88;DISULFIDE BONDS;MUTAGENESIS OF ARG-33; PHE-34; PHE-35; GLU-36; SER-37; HIS-38 AND 33-ARG--HIS-38
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Cited for: X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) OF 22-88 IN COMPLEX WITH HEPARIN DISACCHARIDE I-S;DISULFIDE BONDS;MUTAGENESIS OF ARG-29; ARG-33; 34-PHE-PHE-35; 36-GLU--HIS-38; HIS-46; LYS-48; 52-THR--ALA-56; ARG-62; ARG-68 AND GLN-69
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Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 22-89;DISULFIDE BONDS;MUTAGENESIS OF LYS-22
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Cited for: STRUCTURE BY NMR OF 22-89 OF MUTANT CYS-57 AND CYS-86 IN COMPLEX WITH CXCR4 FRAGMENT;SUBUNIT;DIMERIZATION;DISULFIDE BONDS;MUTAGENESIS OF ARG-41; HIS-46; LYS-48; VAL-60; ARG-62; ARG-68; VAL-70; GLU-81; GLU-84 AND LYS-85
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Cited for: STRUCTURE BY NMR OF 22-89;ASSAY ON RAT ISCHEMIA/REPERFUSION MODEL;DIMERIZATION;DISULFIDE BONDS
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Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 22-88;DIMERIZATION
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Vaild Sequence:
