Senp3 ELISA Kit for Mouse(Mus musculus) | EIAab.comSenp3 ELISA Kit for Mouse(Mus musculus)

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Senp3 (Gene name),

Sentrin-specific protease 3 (Protein name ), SENP3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Senp3(Smt3ip;Smt3ip1);

Protein name:

Sentrin-specific protease 3;

Alternative:

Sentrin/SUMO-specific protease SENP3;SUMO-1-specific protease 3;Smt3-specific isopeptidase 1(Smt3ip1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds to SUMO1 and SUMO3 (By similarity). Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with EP300, NPM1 and CDCA8.

Function:

Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (By similarity). Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability.

Subcellular Location:

Nucleus nucleolus Nucleus nucleoplasm Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress.

Protein Attributes:

Sequence length:

568

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