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Index > Protein center > Senp6(Gene name) > Mouse
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  • Senp6 (Gene name),
  • Sentrin-specific protease 6 (Protein name ),  SENP6_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Senp6(Kiaa0797;Susp1);
    Protein name:
    Sentrin-specific protease 6;
    Alternative:
    Sentrin/SUMO-specific protease SENP6;SUMO-1-specific protease 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.
    Function:
    Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1132
    Sequence:
    50:
    MAAGKSGGSA | GALFLKALDR | SESKRDGGFK | NNWSFDHEEE | SEGDADKDGA | 
    100:
    NLLSVEDEDS | EISKGKKLNR | RSEIVATSSG | DFILKTYVRR | SKTDGFKTLK | 
    150:
    GNPIGLNMLS | NNKKLSESTA | GTALCSGTVV | HGRRFHHAHS | QTPGIRTAAQ | 
    200:
    RKEYPPYVHK | AENSPVMLSH | GQGGDHIMKK | TEESESYVES | EIKRKVQQKR | 
    250:
    HCSTYQLSPL | SPASKKCLTH | LEVSEQREYC | PKCGKEKENQ | TKCQSCGIVF | 
    300:
    HNDLQRNCRQ | AVTLNEPTGP | LLRTSIHQNS | GGQKSQNTGL | TAKKFYGNSV | 
    350:
    DKIPIDILVT | CDDSRHNYIQ | TNGKVILPGG | KIPKLTNPKE | RKISVSDLND | 
    400:
    PIILSSDDDD | DDDDRTKRRE | STSPKPADSA | CSSPVPSTGK | VEAALNADAC | 
    450:
    RAEQEPRSSP | AEPELNTIVI | PRKARMKDQL | GNSISTPLKR | RKVNSHAAFI | 
    500:
    HPMSLSCQNF | ESVILNCRSI | RVGTLFRLLV | EPVIFSLESI | TIHLDGPESD | 
    550:
    PVDIILNTSD | LTKCEWCNVR | KLPVVFLQAI | PAVYQKLSMQ | LQMSKEDKVW | 
    600:
    NDCKGINRIT | SLEEQYIILI | FQTGLDHQAE | VVFESIITDI | GIRNNVPNFF | 
    650:
    AKILFDEANS | RLVACTRSYE | ESIKGNCAQK | ENKVKTVSFE | SKIQLRSKQE | 
    700:
    LQFFDDDEEA | GESHTIFIGP | VEKLIVYPPP | PAKGGISVTN | EDLHCLSEGE | 
    750:
    FLNDVIIDFY | LKYLVLEKLK | KEDADRIHIF | SSFFYKRLNQ | RERRNPETTN | 
    800:
    LSIQQKRHGR | VKTWTRHVDI | FEKDFIFVPL | NEAAHWFLAV | VCFPGLEKPK | 
    850:
    YEPNPHYHEN | AVMQKTPSAE | DSCVSSASEM | GACSQNSAAK | PVIKKMLNRK | 
    900:
    HCLAVTDSSA | AQEESEPCYR | RNAYSVKCSM | KKKNHAINEN | EEPSNGESTC | 
    950:
    QDICDRTQSE | NGLRDECFSS | VHHPDALSKI | RLNYGDQSAD | GGKLLEDELI | 
    1000:
    DFSEDQDDPD | DSSDDGLLAD | ENYSSEIGQW | HLKPTVCKQP | CILLMDSLRG | 
    1050:
    PSRSNVVKIL | REYLEVEWEV | KKGSKRSFSK | DVMKGSNPKV | PQQNNFSDCG | 
    1100:
    VYVLQYVESF | FENPVLNFEL | PMNLMNWFPP | PRMKTKREEI | RNIILKLQES | 
    1132:
    QSKDKKLLKD | SLAETSLGDG | AEQYASASGG | SE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Sentrin-specific protease 6
    ELISA Kit for Mouse Sentrin-specific protease 6
    CLIA Kit for Mouse Sentrin-specific protease 6
    CLIA Kit for Mouse Sentrin-specific protease 6
    Polyclonal Antibody for Mouse Sentrin-specific protease 6
    Polyclonal Antibody for Mouse Sentrin-specific protease 6
    Monoclonal Antibody for Mouse Sentrin-specific protease 6
    Monoclonal Antibody for Mouse Sentrin-specific protease 6
    Protein for Mouse Sentrin-specific protease 6
    Protein for Mouse Sentrin-specific protease 6

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Embryonic tail.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Limb.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-231 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Eye.
      tissue: Thymus.
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