Gene name:
Senp6 (Kiaa0797;Susp1) ;
Protein name:
Sentrin-specific protease 6 ;
Alternative:
Sentrin/SUMO-specific protease SENP6 ;SUMO-1-specific protease 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with RXRA. Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation. Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation.
Function:
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAAGKSGGSA | GALFLKALDR | SESKRDGGFK | NNWSFDHEEE | SEGDADKDGA |
100:
NLLSVEDEDS | EISKGKKLNR | RSEIVATSSG | DFILKTYVRR | SKTDGFKTLK |
150:
GNPIGLNMLS | NNKKLSESTA | GTALCSGTVV | HGRRFHHAHS | QTPGIRTAAQ |
200:
RKEYPPYVHK | AENSPVMLSH | GQGGDHIMKK | TEESESYVES | EIKRKVQQKR |
250:
HCSTYQLSPL | SPASKKCLTH | LEVSEQREYC | PKCGKEKENQ | TKCQSCGIVF |
300:
HNDLQRNCRQ | AVTLNEPTGP | LLRTSIHQNS | GGQKSQNTGL | TAKKFYGNSV |
350:
DKIPIDILVT | CDDSRHNYIQ | TNGKVILPGG | KIPKLTNPKE | RKISVSDLND |
400:
PIILSSDDDD | DDDDRTKRRE | STSPKPADSA | CSSPVPSTGK | VEAALNADAC |
450:
RAEQEPRSSP | AEPELNTIVI | PRKARMKDQL | GNSISTPLKR | RKVNSHAAFI |
500:
HPMSLSCQNF | ESVILNCRSI | RVGTLFRLLV | EPVIFSLESI | TIHLDGPESD |
550:
PVDIILNTSD | LTKCEWCNVR | KLPVVFLQAI | PAVYQKLSMQ | LQMSKEDKVW |
600:
NDCKGINRIT | SLEEQYIILI | FQTGLDHQAE | VVFESIITDI | GIRNNVPNFF |
650:
AKILFDEANS | RLVACTRSYE | ESIKGNCAQK | ENKVKTVSFE | SKIQLRSKQE |
700:
LQFFDDDEEA | GESHTIFIGP | VEKLIVYPPP | PAKGGISVTN | EDLHCLSEGE |
750:
FLNDVIIDFY | LKYLVLEKLK | KEDADRIHIF | SSFFYKRLNQ | RERRNPETTN |
800:
LSIQQKRHGR | VKTWTRHVDI | FEKDFIFVPL | NEAAHWFLAV | VCFPGLEKPK |
850:
YEPNPHYHEN | AVMQKTPSAE | DSCVSSASEM | GACSQNSAAK | PVIKKMLNRK |
900:
HCLAVTDSSA | AQEESEPCYR | RNAYSVKCSM | KKKNHAINEN | EEPSNGESTC |
950:
QDICDRTQSE | NGLRDECFSS | VHHPDALSKI | RLNYGDQSAD | GGKLLEDELI |
1000:
DFSEDQDDPD | DSSDDGLLAD | ENYSSEIGQW | HLKPTVCKQP | CILLMDSLRG |
1050:
PSRSNVVKIL | REYLEVEWEV | KKGSKRSFSK | DVMKGSNPKV | PQQNNFSDCG |
1100:
VYVLQYVESF | FENPVLNFEL | PMNLMNWFPP | PRMKTKREEI | RNIILKLQES |
1132:
QSKDKKLLKD | SLAETSLGDG | AEQYASASGG | SE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse Sentrin-specific protease 6
ELISA Kit for Mouse Sentrin-specific protease 6
CLIA Kit for Mouse Sentrin-specific protease 6
CLIA Kit for Mouse Sentrin-specific protease 6
Polyclonal Antibody for Mouse Sentrin-specific protease 6
Polyclonal Antibody for Mouse Sentrin-specific protease 6
Monoclonal Antibody for Mouse Sentrin-specific protease 6
Monoclonal Antibody for Mouse Sentrin-specific protease 6
Protein for Mouse Sentrin-specific protease 6
Protein for Mouse Sentrin-specific protease 6
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-231 (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Eye .
tissue :
Thymus .