Gene name:
SEPT6 (KIAA0128;SEP2) ;
Protein name:
Septin-6 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT2 and SEPT7. Also interacts with SEPT9 and SEPT12. Interaction with SEPT12 alters filament structure. Interacts with SOCS7. Interacts with HCV NS5B and with HNRNPA1.
Function:
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.
Subcellular Location:
Cytoplasm
Cytoplasm
cytoskeleton
spindle
Chromosome
centromere
kinetochore
Cleavage furrow
Midbody
In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle.
Protein Attributes:
50:
MAATDIARQV | GEGCRTVPLA | GHVGFDSLPD | QLVNKSVSQG | FCFNILCVGE |
100:
TGLGKSTLMD | TLFNTKFEGE | PATHTQPGVQ | LQSNTYDLQE | SNVRLKLTIV |
150:
STVGFGDQIN | KEDSYKPIVE | FIDAQFEAYL | QEELKIRRVL | HTYHDSRIHV |
200:
CLYFIAPTGH | SLKSLDLVTM | KKLDSKVNII | PIIAKADAIS | KSELTKFKIK |
250:
ITSELVSNGV | QIYQFPTDDE | SVAEINGTMN | AHLPFAVIGS | TEELKIGNKM |
300:
MRARQYPWGT | VQVENEAHCD | FVKLREMLIR | VNMEDLREQT | HTRHYELYRR |
350:
CKLEEMGFKD | TDPDSKPFSL | QETYEAKRNE | FLGELQKKEE | EMRQMFVQRV |
400:
KEKEAELKEA | EKELHEKFDR | LKKLHQDEKK | KLEDKKKSLD | DEVNAFKQRK |
434:
TAAELLQSQG | SQAGGSQTLK | RDKEKKNNPW | LCTE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human Septin-6
ELISA Kit for Human Septin-6
ELISA Kit for Human Septin-6
CLIA Kit for Human Septin-6
CLIA Kit for Human Septin-6
CLIA Kit for Human Septin-6
Polyclonal Antibody for Human Septin-6
Polyclonal Antibody for Human Septin-6
Polyclonal Antibody for Human Septin-6
Monoclonal Antibody for Human Septin-6
Monoclonal Antibody for Human Septin-6
Monoclonal Antibody for Human Septin-6
Protein for Human Septin-6
Protein for Human Septin-6
Protein for Human Septin-6
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS I; II; IV AND V)
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more...
Nature434:325-337(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS II AND V)
tissue :
Muscle .
tissue :
Placenta .
tissue :
Testis .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-8;ACETYLATION AT ALA-2
tissue :
Platelet .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-427 (ISOFORM I)
tissue :
Bone marrow .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : COORDINATED EXPRESSION WITH SEPT2 AND SEPT7
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SEPT2 AND SEPT7
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH SOCS7
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SEPT12
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HNRNPA1 AND HCV NS5B;FUNCTION
13.
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
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Science316:1160-1166(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic kidney .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SEPT9
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-367;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 1-427 IN COMPLEX WITH GTP;ELECTRON MICROSCOPY OF SEPTIN COMPLEX;SUBUNIT