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Index > Protein center > SEPT6(Gene name) > Human
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  • SEPT6 (Gene name),
  • Septin-6 (Protein name ),  SEPT6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    SEPT6(KIAA0128;SEP2);
    Protein name:
    Septin-6;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT2 and SEPT7. Also interacts with SEPT9 and SEPT12. Interaction with SEPT12 alters filament structure. Interacts with SOCS7. Interacts with HCV NS5B and with HNRNPA1.
    Function:
    Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.
    Subcellular Location:
    Cytoplasm Cytoplasm cytoskeleton spindle Chromosome centromere kinetochore Cleavage furrow Midbody In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle.
    Protein Attributes:
    Sequence length:
    434
    Sequence:
    50:
    MAATDIARQV | GEGCRTVPLA | GHVGFDSLPD | QLVNKSVSQG | FCFNILCVGE | 
    100:
    TGLGKSTLMD | TLFNTKFEGE | PATHTQPGVQ | LQSNTYDLQE | SNVRLKLTIV | 
    150:
    STVGFGDQIN | KEDSYKPIVE | FIDAQFEAYL | QEELKIRRVL | HTYHDSRIHV | 
    200:
    CLYFIAPTGH | SLKSLDLVTM | KKLDSKVNII | PIIAKADAIS | KSELTKFKIK | 
    250:
    ITSELVSNGV | QIYQFPTDDE | SVAEINGTMN | AHLPFAVIGS | TEELKIGNKM | 
    300:
    MRARQYPWGT | VQVENEAHCD | FVKLREMLIR | VNMEDLREQT | HTRHYELYRR | 
    350:
    CKLEEMGFKD | TDPDSKPFSL | QETYEAKRNE | FLGELQKKEE | EMRQMFVQRV | 
    400:
    KEKEAELKEA | EKELHEKFDR | LKKLHQDEKK | KLEDKKKSLD | DEVNAFKQRK | 
    434:
    TAAELLQSQG | SQAGGSQTLK | RDKEKKNNPW | LCTE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    SMR:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Septin-6
    Cat.:
    E2257h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Septin-6
    Cat.:
    E2257m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Septin-6
    Cat.:
    E2257b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Septin-6
    Cat.:
    U2257h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Septin-6
    Cat.:
    U2257b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Septin-6
    Cat.:
    U2257m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Septin-6
    Cat.:
    P2257Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Septin-6
    Polyclonal Antibody for Human Septin-6
    Cat.:
    P2257Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Septin-6
    Monoclonal Antibody for Human Septin-6
    Monoclonal Antibody for Human Septin-6
    Protein for Human Septin-6
    Protein for Human Septin-6
    Protein for Human Septin-6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24."
      Ono R. , Taki T. , Taketani T. , Kawaguchi H. , Taniwaki M. , Okamura T. , Kawa K. , Hanada R. , Kobayashi M. , Hayashi Y.
      Cancer Res.62:333-337(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS I; II; IV AND V)
    2. 2.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS II AND V)
      tissue: Muscle.
      tissue: Placenta.
      tissue: Testis.
    4. 4.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-8;ACETYLATION AT ALA-2
      tissue: Platelet.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Seki N. , Tanaka A. , Ishikawa K. , Nomura N.
      DNA Res.2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-427 (ISOFORM I)
      tissue: Bone marrow.
    6. 6.
      "Expression profiling the human septin gene family."
      Hall P.A. , Jung K. , Hillan K.J. , Russell S.E.H.
      J. Pathol.206:269-278(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 7.
      "Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4."
      Kremer B.E. , Haystead T. , Macara I.G.
      Mol. Biol. Cell16:4648-4659(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COORDINATED EXPRESSION WITH SEPT2 AND SEPT7
    8. 8.
      "A mitotic septin scaffold required for mammalian chromosome congression and segregation."
      Spiliotis E.T. , Kinoshita M. , Nelson W.J.
      Science307:1781-1785(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "Structural analysis of septin 2, 6, and 7 complexes."
      Low C. , Macara I.G.
      J. Biol. Chem.281:30697-30706(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SEPT2 AND SEPT7
    10. 10.
      "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7."
      Kremer B.E. , Adang L.A. , Macara I.G.
      Cell130:837-850(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SOCS7
    11. 11.
      "SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells."
      Ding X. , Yu W. , Liu M. , Shen S. , Chen F. , Wan B. , Yu L.
      J. Biochem. Mol. Biol.40:973-978(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SEPT12
    12. 12.
      "An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication."
      Kim C.S. , Seol S.K. , Song O.-K. , Park J.H. , Jang S.K.
      J. Virol.81:3852-3865(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HNRNPA1 AND HCV NS5B;FUNCTION
    13. 13.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    14. 14.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SEPT9
    16. 16.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-367;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Structural insight into filament formation by mammalian septins."
      Sirajuddin M. , Farkasovsky M. , Hauer F. , Kuehlmann D. , Macara I.G. , Weyand M. , Stark H. , Wittinghofer A.
      Nature449:311-315(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 1-427 IN COMPLEX WITH GTP;ELECTRON MICROSCOPY OF SEPTIN COMPLEX;SUBUNIT
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