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Index > Protein center > FAM109A(Gene name) > Human
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  • FAM109A (Gene name),
  • Sesquipedalian-1 (Protein name ),  SESQ1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FAM109A;
    Protein name:
    Sesquipedalian-1(Ses1);
    Alternative:
    27 kDa inositol polyphosphate phosphatase-interacting protein A(IPIP27A);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms homodimers and heterodimers with FAM109B. Interacts with OCRL and INPP5B.
    Function:
    Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
    Subcellular Location:
    Early endosome Recycling endosome Golgi apparatus trans-Golgi network Cytoplasmic vesicle clathrin-coated vesicle Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.
    Protein Attributes:
    Sequence length:
    249
    Sequence:
    50:
    MKLNERSLAF | YATCDAPVDN | AGFLYKKGGR | HAAYHRRWFV | LRGNMLFYFE | 
    100:
    DAASREPVGV | IILEGCTVEL | VEAAEEFAFA | VRFAGTRART | YVLAAESQDA | 
    150:
    MEGWVKALSR | ASFDYLRLVV | RELEQQLAAV | RGGGGMALPQ | PQPQSLPLPP | 
    200:
    SLPSALAPVP | SLPSAPAPVP | ALPLPRRPSA | LPPKENGCAV | WSTEATFRPG | 
    249:
    PEPPPPPPRR | RASAPHGPLD | MAPFARLHEC | YGQEIRALRG | QWLSSRVQP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ses1
    ELISA Kit for Human Ses1
    ELISA Kit for Human Ses1
    CLIA Kit for Human Ses1
    CLIA Kit for Human Ses1
    CLIA Kit for Human Ses1
    Polyclonal Antibody for Human Ses1
    Polyclonal Antibody for Human Ses1
    Polyclonal Antibody for Human Ses1
    Monoclonal Antibody for Human Ses1
    Monoclonal Antibody for Human Ses1
    Monoclonal Antibody for Human Ses1
    Protein for Human Ses1
    Protein for Human Ses1
    Protein for Human Ses1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Prostate.
    2. 2.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-80 (ISOFORM 4)
      tissue: Brain.
    4. 4.
      "Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1."
      Swan L.E. , Tomasini L. , Pirruccello M. , Lunardi J. , De Camilli P.
      Proc. Natl. Acad. Sci. U.S.A.107:3511-3516(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH OCRL AND INPP5B;SUBCELLULAR LOCATION;F&H MOTIF;MUTAGENESIS OF PHE-224 AND HIS-228
    5. 5.
      "The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway."
      Noakes C.J. , Lee G. , Lowe M.
      Mol. Biol. Cell22:606-623(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH OCRL AND INPP5B;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF PHE-224; HIS-228 AND 234-GLU-ILE-235
    6. 6.
      "Recognition of the F&H motif by the Lowe syndrome protein OCRL."
      Pirruccello M. , Swan L.E. , Folta-Stogniew E. , De Camilli P.
      Nat. Struct. Mol. Biol.18:789-795(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 223-235 IN COMPLEX WITH OCRL;F&H MOTIF
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