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Index > Protein center > SF3A1(Gene name) > Human
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  • SF3A1 (Gene name),
  • Splicing factor 3A subunit 1 (Protein name ),  SF3A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SF3A1(SAP114);
    Protein name:
    Splicing factor 3A subunit 1;
    Alternative:
    Spliceosome-associated protein 114(SAP 114);SF3a120;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A3.
    Function:
    Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    793
    Sequence:
    50:
    MPAGPVQAVP | PPPPVPTEPK | QPTEEEASSK | EDSAPSKPVV | GIIYPPPEVR | 
    100:
    NIVDKTASFV | ARNGPEFEAR | IRQNEINNPK | FNFLNPNDPY | HAYYRHKVSE | 
    150:
    FKEGKAQEPS | AAIPKVMQQQ | QQTTQQQLPQ | KVQAQVIQET | IVPKEPPPEF | 
    200:
    EFIADPPSIS | AFDLDVVKLT | AQFVARNGRQ | FLTQLMQKEQ | RNYQFDFLRP | 
    250:
    QHSLFNYFTK | LVEQYTKILI | PPKGLFSKLK | KEAENPREVL | DQVCYRVEWA | 
    300:
    KFQERERKKE | EEEKEKERVA | YAQIDWHDFV | VVETVDFQPN | EQGNFPPPTT | 
    350:
    PEELGARILI | QERYEKFGES | EEVEMEVESD | EEDDKQEKAE | EPPSQLDQDT | 
    400:
    QVQDMDEGSD | DEEEGQKVPP | PPETPMPPPL | PPTPDQVIVR | KDYDPKASKP | 
    450:
    LPPAPAPDEY | LVSPITGEKI | PASKMQEHMR | IGLLDPRWLE | QRDRSIREKQ | 
    500:
    SDDEVYAPGL | DIESSLKQLA | ERRTDIFGVE | ETAIGKKIGE | EEIQKPEEKV | 
    550:
    TWDGHSGSMA | RTQQAAQANI | TLQEQIEAIH | KAKGLVPEDD | TKEKIGPSKP | 
    600:
    NEIPQQPPPP | SSATNIPSSA | PPITSVPRPP | TMPPPVRTTV | VSAVPVMPRP | 
    650:
    PMASVVRLPP | GSVIAPMPPI | IHAPRINVVP | MPPSAPPIMA | PRPPPMIVPT | 
    700:
    AFVPAPPVAP | VPAPAPMPPV | HPPPPMEDEP | TSKKLKTEDS | LMPEEEFLRR | 
    750:
    NKGPVSIKVQ | VPNMQDKTEW | KLNGQVLVFT | LPLTDQVSVI | KVKIHEATGM | 
    793:
    PAGKQKLQYE | GIFIKDSNSL | AYYNMANGAV | IHLALKERGG | RKK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    MIM:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Splicing factor 3A subunit 1
    ELISA Kit for Human Splicing factor 3A subunit 1
    ELISA Kit for Human Splicing factor 3A subunit 1
    CLIA Kit for Human Splicing factor 3A subunit 1
    CLIA Kit for Human Splicing factor 3A subunit 1
    CLIA Kit for Human Splicing factor 3A subunit 1
    Polyclonal Antibody for Human Splicing factor 3A subunit 1
    Polyclonal Antibody for Human Splicing factor 3A subunit 1
    Polyclonal Antibody for Human Splicing factor 3A subunit 1
    Monoclonal Antibody for Human Splicing factor 3A subunit 1
    Monoclonal Antibody for Human Splicing factor 3A subunit 1
    Monoclonal Antibody for Human Splicing factor 3A subunit 1
    Protein for Human Splicing factor 3A subunit 1
    Protein for Human Splicing factor 3A subunit 1
    Protein for Human Splicing factor 3A subunit 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae."
      Kraemer A. , Mulhauser F. , Wersig C. , Groning K. , Bilbe G.
      RNA1:260-272(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cervix.
      tissue: Lymph.
    5. 5.
      "Functional association of U2 snRNP with the ATP-independent spliceosomal complex E."
      Das R. , Zhou Z. , Reed R.
      Mol. Cell5:779-787(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE SPLICEOSOME
    6. 6.
      "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S. , Licklider L.J. , Gygi S.P. , Grigorieff N. , Moore M.J.
      RNA8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX
    7. 7.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-456 AND TYR-759;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329 AND SER-359;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
      J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: T-cell.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329; SER-413 AND SER-451;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G. , Ye M. , Zhou H. , Jiang X. , Feng S. , Jiang X. , Tian R. , Wan D. , Zou H. , Gu J.
      Proteomics8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    12. 12.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320; SER-329; SER-359 AND SER-451;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    14. 14.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-55;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329; SER-359; SER-413 AND SER-451;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320; SER-329 AND SER-359;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Solution structure of a human ubiquitin-like domain in SF3A1."
      Structural genomics consortium (SGC)
      Submitted (2005-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 704-789
    19. 19.
      "Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP."
      Kuwasako K. , He F. , Inoue M. , Tanaka A. , Sugano S. , Guntert P. , Muto Y. , Yokoyama S.
      Structure14:1677-1689(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 48-110 AND 134-217 IN COMPLEX WITH SF3A3;SUBUNIT;SURP MOTIFS;MUTAGENESIS OF GLU-48; LYS-55; PHE-162 AND LEU-169
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-511
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