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Index > Protein center > Sf3b1(Gene name) > Mouse
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  • Sf3b1 (Gene name),
  • Splicing factor 3B subunit 1 (Protein name ),  SF3B1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Sf3b1(Sap155);
    Protein name:
    Splicing factor 3B subunit 1;
    Alternative:
    Spliceosome-associated protein 155(SAP 155);Pre-mRNA-splicing factor SF3b 155 kDa subunit(SF3b155);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). SF3B1 interacts directly with the splicing factor U2AF. Phosphorylated form interacts with PPP1R8.
    Function:
    Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1304
    Sequence:
    50:
    MAKIAKTHED | IEAQIREIQG | KKAALDEAQG | VGLDSTGYYD | QEIYGGSDSR | 
    100:
    FAGYVTSIAA | TELEDDDDDY | SSSTSLLGQK | KPGYHAPVAL | LNDIPQSTEQ | 
    150:
    YDPFAEHRPP | KIADREDEYK | KHRRTMIISP | ERLDPFADGG | KTPDPKMNAR | 
    200:
    TYMDVMREQH | LTKEEREIRQ | QLAEKAKAGE | LKVVNGAAAS | QPPSKRKRRW | 
    250:
    DQTADQTPGA | TPKKLSSWDQ | AETPGHTPSL | RWDETPGRAK | GSETPGATPG | 
    300:
    SKIWDPTPSH | TPAGAATPGR | GDTPGHATPG | HGGATSSARK | NRWDETPKTE | 
    350:
    RDTPGHGSGW | AETPRTDRGG | DSIGETPTPG | ASKRKSRWDE | TPASQMGGST | 
    400:
    PVLTPGKTPI | GTPAMNMATP | TPGHIMSMTP | EQLQAWRWER | EIDERNRPLS | 
    450:
    DEELDAMFPE | GYKVLPPPAG | YVPIRTPARK | LTATPTPLGG | MTGFHMQTED | 
    500:
    RTMKSVNDQP | SGNLPFLKPD | DIQYFDKLLV | DVDESTLSPE | EQKERKIMKL | 
    550:
    LLKIKNGTPP | MRKAALRQIT | DKAREFGAGP | LFNQILPLLM | SPTLEDQERH | 
    600:
    LLVKVIDRIL | YKLDDLVRPY | VHKILVVIEP | LLIDEDYYAR | VEGREIISNL | 
    650:
    AKAAGLATMI | STMRPDIDNM | DEYVRNTTAR | AFAVVASALG | IPSLLPFLKA | 
    700:
    VCKSKKSWQA | RHTGIKIVQQ | IAILMGCAIL | PHLRSLVEII | EHGLVDEQQK | 
    750:
    VRTISALAIA | ALAEAATPYG | IESFDSVLKP | LWKGIRQHRG | KGLAAFLKAI | 
    800:
    GYLIPLMDAE | YANYYTREVM | LILIREFQSP | DEEMKKIVLK | VVKQCCGTDG | 
    850:
    VEANYIKTEI | LPPFFKHFWQ | HRMALDRRNY | RQLVDTTVEL | ANKVGAAEII | 
    900:
    SRIVDDLKDE | AEQYRKMVME | TIEKIMGNLG | AADIDHKLEE | QLIDGILYAF | 
    950:
    QEQTTEDSVM | LNGFGTVVNA | LGKRVKPYLP | QICGTVLWRL | NNKSAKVRQQ | 
    1000:
    AADLISRTAV | VMKTCQEEKL | MGHLGVVLYE | YLGEEYPEVL | GSILGALKAI | 
    1050:
    VNVIGMHKMT | PPIKDLLPRL | TPILKNRHEK | VQENCIDLVG | RIADRGAEYV | 
    1100:
    SAREWMRICF | ELLELLKAHK | KAIRRATVNT | FGYIAKAIGP | HDVLATLLNN | 
    1150:
    LKVQERQNRV | CTTVAIAIVA | ETCSPFTVLP | ALMNEYRVPE | LNVQNGVLKS | 
    1200:
    LSFLFEYIGE | MGKDYIYAVT | PLLEDALMDR | DLVHRQTASA | VVQHMSLGVY | 
    1250:
    GFGCEDSLNH | LLNYVWPNVF | ETSPHVIQAV | MGALEGLRVA | IGPCRMLQYC | 
    1300:
    LQGLFHPARK | VRDVYWKIYN | SIYIGSQDAL | IAHYPRIYND | DKNTYIRYDL | 
    1304:
    DYIL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Splicing factor 3B subunit 1
    ELISA Kit for Mouse Splicing factor 3B subunit 1
    CLIA Kit for Mouse Splicing factor 3B subunit 1
    CLIA Kit for Mouse Splicing factor 3B subunit 1
    Polyclonal Antibody for Mouse Splicing factor 3B subunit 1
    Polyclonal Antibody for Mouse Splicing factor 3B subunit 1
    Monoclonal Antibody for Mouse Splicing factor 3B subunit 1
    Monoclonal Antibody for Mouse Splicing factor 3B subunit 1
    Protein for Mouse Splicing factor 3B subunit 1
    Protein for Mouse Splicing factor 3B subunit 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Molecular cloning, genetic mapping, and expression of the mouse Sf3b1 (SAP155) gene for the U2 snRNP component of spliceosome."
      Isono K. , Abe K. , Tomaru Y. , Okazaki Y. , Hayashizaki Y. , Koseki H.
      Mamm. Genome12:192-198(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Ovary.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-490
      strain: C57BL/6J.
      tissue: Embryo.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-207; THR-211; THR-267 AND THR-326;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    4. 4.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CITRULLINATION AT ARG-157
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