Gene name:
Sf3b1 (Sap155) ;
Protein name:
Splicing factor 3B subunit 1 ;
Alternative:
Spliceosome-associated protein 155 (SAP 155) ;Pre-mRNA-splicing factor SF3b 155 kDa subunit (SF3b155) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). SF3B1 interacts directly with the splicing factor U2AF. Phosphorylated form interacts with PPP1R8.
Function:
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAKIAKTHED | IEAQIREIQG | KKAALDEAQG | VGLDSTGYYD | QEIYGGSDSR |
100:
FAGYVTSIAA | TELEDDDDDY | SSSTSLLGQK | KPGYHAPVAL | LNDIPQSTEQ |
150:
YDPFAEHRPP | KIADREDEYK | KHRRTMIISP | ERLDPFADGG | KTPDPKMNAR |
200:
TYMDVMREQH | LTKEEREIRQ | QLAEKAKAGE | LKVVNGAAAS | QPPSKRKRRW |
250:
DQTADQTPGA | TPKKLSSWDQ | AETPGHTPSL | RWDETPGRAK | GSETPGATPG |
300:
SKIWDPTPSH | TPAGAATPGR | GDTPGHATPG | HGGATSSARK | NRWDETPKTE |
350:
RDTPGHGSGW | AETPRTDRGG | DSIGETPTPG | ASKRKSRWDE | TPASQMGGST |
400:
PVLTPGKTPI | GTPAMNMATP | TPGHIMSMTP | EQLQAWRWER | EIDERNRPLS |
450:
DEELDAMFPE | GYKVLPPPAG | YVPIRTPARK | LTATPTPLGG | MTGFHMQTED |
500:
RTMKSVNDQP | SGNLPFLKPD | DIQYFDKLLV | DVDESTLSPE | EQKERKIMKL |
550:
LLKIKNGTPP | MRKAALRQIT | DKAREFGAGP | LFNQILPLLM | SPTLEDQERH |
600:
LLVKVIDRIL | YKLDDLVRPY | VHKILVVIEP | LLIDEDYYAR | VEGREIISNL |
650:
AKAAGLATMI | STMRPDIDNM | DEYVRNTTAR | AFAVVASALG | IPSLLPFLKA |
700:
VCKSKKSWQA | RHTGIKIVQQ | IAILMGCAIL | PHLRSLVEII | EHGLVDEQQK |
750:
VRTISALAIA | ALAEAATPYG | IESFDSVLKP | LWKGIRQHRG | KGLAAFLKAI |
800:
GYLIPLMDAE | YANYYTREVM | LILIREFQSP | DEEMKKIVLK | VVKQCCGTDG |
850:
VEANYIKTEI | LPPFFKHFWQ | HRMALDRRNY | RQLVDTTVEL | ANKVGAAEII |
900:
SRIVDDLKDE | AEQYRKMVME | TIEKIMGNLG | AADIDHKLEE | QLIDGILYAF |
950:
QEQTTEDSVM | LNGFGTVVNA | LGKRVKPYLP | QICGTVLWRL | NNKSAKVRQQ |
1000:
AADLISRTAV | VMKTCQEEKL | MGHLGVVLYE | YLGEEYPEVL | GSILGALKAI |
1050:
VNVIGMHKMT | PPIKDLLPRL | TPILKNRHEK | VQENCIDLVG | RIADRGAEYV |
1100:
SAREWMRICF | ELLELLKAHK | KAIRRATVNT | FGYIAKAIGP | HDVLATLLNN |
1150:
LKVQERQNRV | CTTVAIAIVA | ETCSPFTVLP | ALMNEYRVPE | LNVQNGVLKS |
1200:
LSFLFEYIGE | MGKDYIYAVT | PLLEDALMDR | DLVHRQTASA | VVQHMSLGVY |
1250:
GFGCEDSLNH | LLNYVWPNVF | ETSPHVIQAV | MGALEGLRVA | IGPCRMLQYC |
1300:
LQGLFHPARK | VRDVYWKIYN | SIYIGSQDAL | IAHYPRIYND | DKNTYIRYDL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse Splicing factor 3B subunit 1
ELISA Kit for Mouse Splicing factor 3B subunit 1
CLIA Kit for Mouse Splicing factor 3B subunit 1
CLIA Kit for Mouse Splicing factor 3B subunit 1
Polyclonal Antibody for Mouse Splicing factor 3B subunit 1
Polyclonal Antibody for Mouse Splicing factor 3B subunit 1
Monoclonal Antibody for Mouse Splicing factor 3B subunit 1
Monoclonal Antibody for Mouse Splicing factor 3B subunit 1
Protein for Mouse Splicing factor 3B subunit 1
Protein for Mouse Splicing factor 3B subunit 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Ovary .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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