SFRP1 ELISA Kit for Human(Homo sapiens) | EIAab.comSFRP1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SFRP1(Gene name) > Human

SFRP1 (Gene name),

Secreted frizzled-related protein 1 (Protein name ), SFRP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SFRP1(FRP;FRP1;SARP2);

Protein name:

Secreted frizzled-related protein 1(FRP-1;sFRP-1);

Alternative:

Secreted apoptosis-related protein 2(SARP-2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8.

Function:

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Subcellular Location:

Secreted Cell membrane or extracellular matrix-associated. Released by heparin-binding.

Protein Attributes:

Sequence length:

314

Sequence:

50:

100:

150:

200:

250:

300:

314:

MKNHECPTFQ | SVFK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

604156

Pfam:

PF01392

SMR:

Q8N474

String:

Q8N474

KEGG:

hsa:6422

UniGene:

Hs.213424

STRING:

9606.ENSP00000220772

Uniprot:

Q8N474

FOR

ELISA Kit for Human FRP-1

Cat.:

E1165m

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Packing:

96T

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ELISA Kit for Human FRP-1

Cat.:

E1165h

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96T

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ELISA Kit for Human FRP-1

Cat.:

E1165b

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MSDS:

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96T

ELISA Kit for Human FRP-1

Cat.:

E1165r

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96T

ELISA Kit for Human FRP-1

Cat.:

E1165c

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Packing:

96T

CLIA Kit for Human FRP-1

Cat.:

U1165m

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MSDS:

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Packing:

96T

CLIA Kit for Human FRP-1

Cat.:

U1165h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human FRP-1

Cat.:

U1165c

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MSDS:

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Packing:

96T

CLIA Kit for Human FRP-1

Cat.:

U1165r

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MSDS:

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Packing:

96T

CLIA Kit for Human FRP-1

Cat.:

U1165b

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Packing:

96T

Polyclonal Antibody for Human FRP-1

Cat.:

P1165Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human FRP-1

Cat.:

P1165Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human FRP-1

Cat.:

P1165Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human FRP-1

Protein for Human FRP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action."
Finch P.W. , He X. , Kelley M.J. , Uren A. , Schaudies R.P. , Popescu N.C. , Rudikoff S. , Aaronson S.A. , Varmus H.E. , Rubin J.S.
Proc. Natl. Acad. Sci. U.S.A.94:6770-6775(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 39-78
tissue: Embryonic lung fibroblast.
2.

"SARPs: a family of secreted apoptosis-related proteins."
Melkonyan H.S. , Chang W.C. , Shapiro J.P. , Mahadevappa M. , Fitzpatrick P.A. , Kiefer M.C. , Tomei L.D. , Umansky S.R.
Proc. Natl. Acad. Sci. U.S.A.94:13636-13641(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Heart.
3.

"Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors."
Zhou Z. , Wang J. , Han X. , Zhou J. , Linder S.
Int. J. Cancer78:95-99(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
5.

"Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules."
Chong J.M. , Ueren A. , Rubin J.S. , Speicher D.W.
J. Biol. Chem.277:5134-5144(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-314;DISULFIDE BONDS;MASS SPECTROMETRY;GLYCOSYLATION AT ASN-173;MUTAGENESIS OF ASN-173 AND ASN-263
6.

"Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling."
Bafico A. , Gazit A. , Pramila T. , Finch P.W. , Yaniv A. , Aaronson S.A.
J. Biol. Chem.274:16180-16187(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WNT1; WNT2 AND FRZD6
7.

"Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity."
Fukuhara K. , Kariya M. , Kita M. , Shime H. , Kanamori T. , Kosaka C. , Orii A. , Fujita J. , Fujii S.
J. Clin. Endocrinol. Metab.87:1729-1736(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION

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