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Index > Protein center > Sfrp1(Gene name) > Mouse
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  • Sfrp1 (Gene name),
  • Secreted frizzled-related protein 1 (Protein name ),  SFRP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Sfrp1;
    Protein name:
    Secreted frizzled-related protein 1(sFRP-1);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with WNT8. Interacts with WNT1, WNT2, WNT4 and FRZD6.
    Function:
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
    Subcellular Location:
    Secreted Cell membrane or extracellular matrix-associated. Released by heparin-binding.
    Protein Attributes:
    Sequence length:
    314
    Sequence:
    50:
    MGVGRSARGR | GGAASGVLLA | LAAALLAAGS | ASEYDYVSFQ | SDIGSYQSGR | 
    100:
    FYTKPPQCVD | IPVDLRLCHN | VGYKKMVLPN | LLEHETMAEV | KQQASSWVPL | 
    150:
    LNKNCHMGTQ | VFLCSLFAPV | CLDRPIYPCR | WLCEAVRDSC | EPVMQFFGFY | 
    200:
    WPEMLKCDKF | PEGDVCIAMT | PPNTTEASKP | QGTTVCPPCD | NELKSEAIIE | 
    250:
    HLCASEFALR | MKIKEVKKEN | GDKKIVPKKK | KPLKLGPIKK | KELKRLVLFL | 
    300:
    KNGADCPCHQ | LDNLSHNFLI | MGRKVKSQYL | LTAIHKWDKK | NKEFKNFMKR | 
    314:
    MKNHECPTFQ | SVFK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse sFRP-1
    Cat.:
    E1165m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse sFRP-1
    Cat.:
    E1165h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse sFRP-1
    Cat.:
    E1165b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse sFRP-1
    Cat.:
    E1165r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse sFRP-1
    Cat.:
    E1165c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse sFRP-1
    Cat.:
    U1165m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse sFRP-1
    Cat.:
    U1165h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse sFRP-1
    Cat.:
    U1165c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse sFRP-1
    Cat.:
    U1165r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse sFRP-1
    Cat.:
    U1165b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse sFRP-1
    Polyclonal Antibody for Mouse sFRP-1
    Cat.:
    P1165Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse sFRP-1
    Polyclonal Antibody for Mouse sFRP-1
    Cat.:
    P1165Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse sFRP-1
    Cat.:
    P1165Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse sFRP-1
    Monoclonal Antibody for Mouse sFRP-1
    Monoclonal Antibody for Mouse sFRP-1
    Monoclonal Antibody for Mouse sFRP-1
    Monoclonal Antibody for Mouse sFRP-1
    Protein for Mouse sFRP-1
    Protein for Mouse sFRP-1
    Protein for Mouse sFRP-1
    Protein for Mouse sFRP-1
    Protein for Mouse sFRP-1

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    References
    1. 1.
      "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors."
      Rattner A. , Hsieh J.-C. , Smallwood P.M. , Gilbert D.J. , Copeland N.G. , Jenkins N.A. , Nathans J.
      Proc. Natl. Acad. Sci. U.S.A.94:2859-2863(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      strain: C57BL/6J.
      tissue: Embryonic eye.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Colon.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-314
      strain: C57BL/6J.
      tissue: Cerebellum.
    4. 4.
      "Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family."
      Leimeister C. , Bach A. , Gessler M.
      Mech. Dev.75:29-42(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    5. 5.
      "Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis."
      Jaspard B. , Couffinhal T. , Dufourcq P. , Moreau C. , Duplaa C.
      Mech. Dev.90:263-267(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WNT8;DEVELOPMENTAL STAGE
    6. 6.
      "FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo."
      Ezan J. , Leroux L. , Barandon L. , Dufourcq P. , Jaspard B. , Moreau C. , Allieres C. , Daret D. , Couffinhal T. , Duplaa C.
      Cardiovasc. Res.63:731-738(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN ANGIOGENIC FACTOR
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOC
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