Protein name:
Secreted frizzled-related protein 1 (sFRP-1) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with WNT8. Interacts with WNT1, WNT2, WNT4 and FRZD6.
Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Subcellular Location:
Secreted
Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Protein Attributes:
50:
MGVGRSARGR | GGAASGVLLA | LAAALLAAGS | ASEYDYVSFQ | SDIGSYQSGR |
100:
FYTKPPQCVD | IPVDLRLCHN | VGYKKMVLPN | LLEHETMAEV | KQQASSWVPL |
150:
LNKNCHMGTQ | VFLCSLFAPV | CLDRPIYPCR | WLCEAVRDSC | EPVMQFFGFY |
200:
WPEMLKCDKF | PEGDVCIAMT | PPNTTEASKP | QGTTVCPPCD | NELKSEAIIE |
250:
HLCASEFALR | MKIKEVKKEN | GDKKIVPKKK | KPLKLGPIKK | KELKRLVLFL |
300:
KNGADCPCHQ | LDNLSHNFLI | MGRKVKSQYL | LTAIHKWDKK | NKEFKNFMKR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
Rat
Chicken
ELISA Kit for Mouse sFRP-1
ELISA Kit for Mouse sFRP-1
ELISA Kit for Mouse sFRP-1
ELISA Kit for Mouse sFRP-1
ELISA Kit for Mouse sFRP-1
CLIA Kit for Mouse sFRP-1
CLIA Kit for Mouse sFRP-1
CLIA Kit for Mouse sFRP-1
CLIA Kit for Mouse sFRP-1
CLIA Kit for Mouse sFRP-1
Polyclonal Antibody for Mouse sFRP-1
Polyclonal Antibody for Mouse sFRP-1
Polyclonal Antibody for Mouse sFRP-1
Polyclonal Antibody for Mouse sFRP-1
Polyclonal Antibody for Mouse sFRP-1
Monoclonal Antibody for Mouse sFRP-1
Monoclonal Antibody for Mouse sFRP-1
Monoclonal Antibody for Mouse sFRP-1
Monoclonal Antibody for Mouse sFRP-1
Monoclonal Antibody for Mouse sFRP-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain :
C57BL/6J .
tissue :
Embryonic eye .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
strain :
FVB/N .
tissue :
Brain .
tissue :
Colon .
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-314
strain :
C57BL/6J .
tissue :
Cerebellum .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WNT8;DEVELOPMENTAL STAGE
6.
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Cardiovasc. Res.63:731-738(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS AN ANGIOGENIC FACTOR
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MYOC