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Index > Protein center > SFRP4(Gene name) > Human
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  • SFRP4 (Gene name),
  • Secreted frizzled-related protein 4 (Protein name ),  SFRP4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SFRP4(FRPHE);
    Protein name:
    Secreted frizzled-related protein 4(sFRP-4);
    Alternative:
    Frizzled protein, human endometrium(FrpHE);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
    Subcellular Location:
    Secreted Cytoplasmic in ovarian tumor cells.
    Protein Attributes:
    Sequence length:
    346
    Sequence:
    50:
    MFLSILVALC | LWLHLALGVR | GAPCEAVRIP | MCRHMPWNIT | RMPNHLHHST | 
    100:
    QENAILAIEQ | YEELVDVNCS | AVLRFFLCAM | YAPICTLEFL | HDPIKPCKSV | 
    150:
    CQRARDDCEP | LMKMYNHSWP | ESLACDELPV | YDRGVCISPE | AIVTDLPEDV | 
    200:
    KWIDITPDMM | VQERPLDVDC | KRLSPDRCKC | KKVKPTLATY | LSKNYSYVIH | 
    250:
    AKIKAVQRSG | CNEVTTVVDV | KEIFKSSSPI | PRTQVPLITN | SSCQCPHILP | 
    300:
    HQDVLIMCYE | WRSRMMLLEN | CLVEKWRDQL | SKRSIQWEER | LQEQRRTVQD | 
    346:
    KKKTAGRTSR | SNPPKPKGKP | PAPKPASPKK | NIKTRSAQKR | TNPKRV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    MIM:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human sFRP-4
    Cat.:
    E1650m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human sFRP-4
    Cat.:
    E1650h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human sFRP-4
    Cat.:
    E1650r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human sFRP-4
    Cat.:
    U1650h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human sFRP-4
    Cat.:
    U1650m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human sFRP-4
    Cat.:
    U1650r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human sFRP-4
    Cat.:
    P1650Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human sFRP-4
    Cat.:
    P1650Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human sFRP-4
    Cat.:
    P1650Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human sFRP-4
    Monoclonal Antibody for Human sFRP-4
    Monoclonal Antibody for Human sFRP-4
    Protein for Human sFRP-4
    Protein for Human sFRP-4
    Protein for Human sFRP-4

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    Linearity
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    References
    1. 1.
      "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy."
      Abu-Jawdeh G.M. , Comella N. , Brown L.F. , Tognazzi K. , Kocher O.
      Lab. Invest.79:439-447(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Endometrium.
    2. 2.
      "Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent."
      Berndt T. , Craig T.A. , Bowe A.E. , Vassiliadis J. , Reczek D. , Finnegan R. , Jan De Beur S.M. , Schiavi S.C. , Kumar R.
      J. Clin. Invest.112:785-794(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];POSSIBLE FUNCTION AS A PHOSPHATURIC AGENT
      tissue: Mesenchymal tumor.
    3. 3.
      "Open reading frame of the human secreted frizzled related protein 4."
      Drake J.M. , Zeps N. , Dharmarajan A.
      Submitted (2006-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-320
      tissue: Ovary.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS THR-320 AND LYS-340
      tissue: Testis.
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Human chromosome 7: DNA sequence and biology."
      Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
      Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT THR-320
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS THR-320 AND LYS-340
      tissue: Brain.
    9. 9.
      "Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression."
      Schumann H. , Holtz J. , Zerkowski H.R. , Hatzfeld M.
      Cardiovasc. Res.45:720-728(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 10.
      "Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours."
      Drake J. , Shearwood A.M. , White J. , Friis R. , Zeps N. , Charles A. , Dharmarajan A.
      Eur. J. Gynaecol. Oncol.30:133-141(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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