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Index > Protein center > SFTPA1(Gene name) > Human
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  • SFTPA1 (Gene name),
  • Pulmonary surfactant-associated protein A1 (Protein name ),  SFTA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SFTPA1(COLEC4;PSAP;SFTP1;SFTPA;SFTPA1B);
    Protein name:
    Pulmonary surfactant-associated protein A1(PSP-A;PSPA;SP-A;SP-A1);
    Alternative:
    Alveolar proteinosis protein;35 kDa pulmonary surfactant-associated protein;Collectin-4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Oligomeric complex of 6 set of homotrimers.
    Function:
    In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
    Subcellular Location:
    Secreted extracellular space extracellular matrix Secreted extracellular space surface film
    Protein Attributes:
    Sequence length:
    248
    Sequence:
    50:
    MWLCPLALNL | ILMAASGAVC | EVKDVCVGSP | GIPGTPGSHG | LPGRDGRDGL | 
    100:
    KGDPGPPGPM | GPPGEMPCPP | GNDGLPGAPG | IPGECGEKGE | PGERGPPGLP | 
    150:
    AHLDEELQAT | LHDFRHQILQ | TRGALSLQGS | IMTVGEKVFS | SNGQSITFDA | 
    200:
    IQEACARAGG | RIAVPRNPEE | NEAIASFVKK | YNTYAYVGLT | EGPSPGDFRY | 
    248:
    SDGTPVNYTN | WYRGEPAGRG | KEQCVEMYTD | GQWNDRNCLY | SRLTICEF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    SMR:
    String:
    UniGene:
    Uniprot:
     
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    ELISA Kit for Human PSP-A
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    ELISA Kit for Human PSP-A
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    CLIA Kit for Human PSP-A
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    CLIA Kit for Human PSP-A
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    CLIA Kit for Human PSP-A
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    CLIA Kit for Human PSP-A
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    CLIA Kit for Human PSP-A
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    Polyclonal Antibody for Human PSP-A
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    P0890Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PSP-A
    Polyclonal Antibody for Human PSP-A
    Polyclonal Antibody for Human PSP-A
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    Polyclonal Antibody for Human PSP-A
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    Packing:
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    Polyclonal Antibody for Human PSP-A
    Polyclonal Antibody for Human PSP-A
    Monoclonal Antibody for Human PSP-A
    Monoclonal Antibody for Human PSP-A
    Monoclonal Antibody for Human PSP-A
    Monoclonal Antibody for Human PSP-A
    Monoclonal Antibody for Human PSP-A
    Monoclonal Antibody for Human PSP-A
    Monoclonal Antibody for Human PSP-A
    Protein for Human PSP-A
    Protein for Human PSP-A
    Protein for Human PSP-A
    Protein for Human PSP-A
    Protein for Human PSP-A
    Protein for Human PSP-A
    Protein for Human PSP-A

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    References
    1. 1.
      "Isolation and characterization of the human pulmonary surfactant apoprotein gene."
      White R.T. , Damm D. , Miller J. , Spratt K. , Schilling J. , Hawgood S. , Benson B. , Cordell B.
      Nature317:361-363(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein."
      Floros J. , Steinbrink R. , Jacobs K. , Phelps D. , Kriz R. , Recny M. , Sultzman L. , Jones S. , Taeusch H.W. , Frank H.A. , Fritsch E.F.
      J. Biol. Chem.261:9029-9033(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-19;ACETYLATION AT GLU-21
    3. 3.
      "Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene."
      Silveyra P. , Wang G. , Floros J.
      Am. J. Physiol.299:L523-L534(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ALA-19; VAL-50 AND TRP-219
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-9; ALA-19; VAL-50 AND TRP-219
    6. 6.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    10. 10.
      "Genetics of the hydrophilic surfactant proteins A and D."
      Floros J. , Hoover R.R.
      Biochim. Biophys. Acta1408:312-322(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEFINITION OF SFTPA1 ALLELES
    11. 11.
      "Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population."
      Raemet M. , Haataja R. , Marttila R. , Floros J. , Hallman M.
      Am. J. Hum. Genet.66:1569-1579(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RDS
    12. 12.
      "Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis."
      Selman M. , Lin H.-M. , Montano M. , Jenkins A.L. , Estrada A. , Lin Z. , Wang G. , DiAngelo S.L. , Guo X. , Umstead T.M. , Lang C.M. , Pardo A. , Phelps D.S. , Floros J.
      Hum. Genet.113:542-550(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-219;ASSOCIATION WITH IDIOPATHIC PULMONARY FIBROSIS
    13. 13.
      "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."
      Wang Y. , Kuan P.J. , Xing C. , Cronkhite J.T. , Torres F. , Rosenblatt R.L. , DiMaio J.M. , Kinch L.N. , Grishin N.V. , Garcia C.K.
      Am. J. Hum. Genet.84:52-59(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-5; THR-9; ALA-19; VAL-50 AND TRP-219
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