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Index > Protein center > SFTPD(Gene name) > Human
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  • SFTPD (Gene name),
  • Pulmonary surfactant-associated protein D (Protein name ),  SFTPD_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    SFTPD(COLEC7;PSPD;SFTP4);
    Protein name:
    Pulmonary surfactant-associated protein D(PSP-D;SP-D);
    Alternative:
    Collectin-7;Lung surfactant protein D;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Oligomeric complex of 4 set of homotrimers.
    Function:
    Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
    Subcellular Location:
    Secreted extracellular space extracellular matrix Secreted extracellular space surface film
    Protein Attributes:
    Sequence length:
    375
    Sequence:
    50:
    MLLFLLSALV | LLTQPLGYLE | AEMKTYSHRT | MPSACTLVMC | SSVESGLPGR | 
    100:
    DGRDGREGPR | GEKGDPGLPG | AAGQAGMPGQ | AGPVGPKGDN | GSVGEPGPKG | 
    150:
    DTGPSGPPGP | PGVPGPAGRE | GPLGKQGNIG | PQGKPGPKGE | AGPKGEVGAP | 
    200:
    GMQGSAGARG | LAGPKGERGV | PGERGVPGNT | GAAGSAGAMG | PQGSPGARGP | 
    250:
    PGLKGDKGIP | GDKGAKGESG | LPDVASLRQQ | VEALQGQVQH | LQAAFSQYKK | 
    300:
    VELFPNGQSV | GEKIFKTAGF | VKPFTEAQLL | CTQAGGQLAS | PRSAAENAAL | 
    350:
    QQLVVAKNEA | AFLSMTDSKT | EGKFTYPTGE | SLVYSNWAPG | EPNDDGGSED | 
    375:
    CVEIFTNGKW | NDRACGEKRL | VVCEF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    Pfam:
    KEGG:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human PSP-D
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    E1039h
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    96T
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    ELISA Kit for Human PSP-D
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    E1039m
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    MSDS:
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    96T
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    ELISA Kit for Human PSP-D
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    E1039b
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    96T
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    ELISA Kit for Human PSP-D
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    E1039p
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    96T
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    ELISA Kit for Human PSP-D
    Cat.:
    E1039r
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    MSDS:
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    96T
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    CLIA Kit for Human PSP-D
    Cat.:
    U1039r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human PSP-D
    Cat.:
    U1039b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PSP-D
    Cat.:
    U1039m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PSP-D
    Cat.:
    U1039h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PSP-D
    Cat.:
    U1039p
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PSP-D
    Cat.:
    P1039Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PSP-D
    Cat.:
    P1039Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PSP-D
    Cat.:
    P1039Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PSP-D
    Polyclonal Antibody for Human PSP-D
    Monoclonal Antibody for Human PSP-D
    Monoclonal Antibody for Human PSP-D
    Monoclonal Antibody for Human PSP-D
    Monoclonal Antibody for Human PSP-D
    Monoclonal Antibody for Human PSP-D
    Protein for Human PSP-D
    Protein for Human PSP-D
    Protein for Human PSP-D
    Protein for Human PSP-D
    Protein for Human PSP-D

    R&D Technical Data

    12% SDS-PAGE analysis

         12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    Citations
    [1].
    VN Ambade, AN Sontakke, MS Barthwal, et al.
    References
    1. 1.
      "Purification, characterization and cDNA cloning of human lung surfactant protein D."
      Lu J. , Willis A.C. , Reid K.B.M.
      Biochem. J.284:795-802(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 214-243;VARIANTS THR-31 AND ALA-180
      tissue: Amniotic fluid.
      tissue: Lung.
    2. 2.
      "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1."
      Crouch E. , Rust K. , Veile R. , Donis-Keller H. , Grosso L.
      J. Biol. Chem.268:2976-2983(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS THR-31 AND ALA-180
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-31; VAL-123; ALA-180; THR-290 AND LYS-309
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    7. 7.
      "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis."
      Crouch E. , Persson A. , Chang D.
      Am. J. Pathol.142:241-248(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 46-72 AND 223-260
    8. 8.
      "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain."
      Rust K. , Grosso L. , Zhang V. , Chang D. , Persson A. , Longmore W. , Cai G.-Z. , Crouch E.
      Arch. Biochem. Biophys.290:116-126(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-375;PARTIAL PROTEIN SEQUENCE
      tissue: Lung.
    9. 9.
      "The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status."
      Ortega F.J. , Pueyo N. , Moreno-Navarrete J.M. , Sabater M. , Rodriguez-Hermosa J.I. , Ricart W. , Tinahones F.J. , Fernandez-Real J.M.
      Int. J. Obes. Relat. Metab. Disord.37:1532-1538(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    10. 10.
      "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D."
      Hakansson K. , Lim N.K. , Hoppe H.-J. , Reid K.B.M.
      Structure7:255-264(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
    11. 11.
      "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."
      Wang Y. , Kuan P.J. , Xing C. , Cronkhite J.T. , Torres F. , Rosenblatt R.L. , DiMaio J.M. , Kinch L.N. , Grishin N.V. , Garcia C.K.
      Am. J. Hum. Genet.84:52-59(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-31; VAL-123; ALA-180 AND THR-290
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