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Index > Protein center > SH2D1B(Gene name) > Human
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  • SH2D1B (Gene name),
  • SH2 domain-containing protein 1B (Protein name ),  SH21B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SH2D1B(EAT2);
    Protein name:
    SH2 domain-containing protein 1B;
    Alternative:
    EWS/FLI1-activated transcript 2(EAT-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to the phosphorylated receptors CD84, SLAMF1, LY9 and CD244. Does not bind to non-phosphorylated SLAMF1.
    Function:
    Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    132
    Sequence:
    50:
    MDLPYYHGRL | TKQDCETLLL | KEGVDGNFLL | RDSESIPGVL | CLCVSFKNIV | 
    100:
    YTYRIFREKH | GYYRIQTAEG | SPKQVFPSLK | ELISKFEKPN | QGMVVHLLKP | 
    132:
    IKRTSPSLRW | RGLKLELETF | VNSNSDYVDV | LP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human SH2 domain-containing protein 1B
    ELISA Kit for Human SH2 domain-containing protein 1B
    CLIA Kit for Human SH2 domain-containing protein 1B
    CLIA Kit for Human SH2 domain-containing protein 1B
    Polyclonal Antibody for Human SH2 domain-containing protein 1B
    Polyclonal Antibody for Human SH2 domain-containing protein 1B
    Monoclonal Antibody for Human SH2 domain-containing protein 1B
    Monoclonal Antibody for Human SH2 domain-containing protein 1B
    Protein for Human SH2 domain-containing protein 1B
    Protein for Human SH2 domain-containing protein 1B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells."
      Morra M. , Lu J. , Poy F. , Martin M. , Sayos J. , Calpe S. , Gullo C. , Howie D. , Rietdijk S. , Thompson A. , Coyle A.J. , Denny C. , Yaffe M.B. , Engel P. , Eck M.J. , Terhorst C.
      EMBO J.20:5840-5852(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION
    2. 2.
      Colonna M.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Leukocyte.
    3. 3.
      "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2."
      Tangye S.G. , van de Weerdt B.C.M. , Avery D.T. , Hodgkin P.D.
      Eur. J. Immunol.32:1640-1649(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH CD84;VARIANT LYS-122
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Spleen.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Leukocyte.
      tissue: Lung.
    8. 8.
      "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene."
      Thompson A.D. , Braun B.S. , Arvand A. , Stewart S.D. , May W.A. , Chen E. , Korenberg J. , Denny C.
      Oncogene13:2649-2658(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45
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