Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > INPP5D(Gene name) > Human
  • Add your favorite
  • INPP5D (Gene name),
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (Protein name ),  SHIP1_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Citations  (1)
  • |
  • Feedback
  • Gene name:
    INPP5D(SHIP;SHIP1);
    Protein name:
    Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1;
    Alternative:
    SH2 domain-containing inositol-5'-phosphatase 1(SH2 domain-containing inositol phosphatase 1;SHIP-1);Inositol polyphosphate-5-phosphatase of 145 kDa(SIP-145);p150Ship(hp51CN);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with tyrosine phosphorylated forms of SHC1, DOK1, DOK3, PTPN11/SHP-2, SLAMF1/CD150. Interacts with PTPN11 in response to IL-3. Interacts with receptors EPOR, MS4A2/FCER1B and FCER1G, FCGR2A, FCGR2B and FCGR3. Interacts with GRB2 and PLCG1. Interacts with tyrosine kinases SRC and TEC. Interacts with FCGR2A, leading to regulate gene expression during the phagocytic process. Interacts with c-Met/MET (By similarity). Interacts with MILR1 (tyrosine-phosphorylated).
    Function:
    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
    Subcellular Location:
    Cytoplasm Membrane Peripheral membrane protein Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate to membrane localization.
    Protein Attributes:
    Sequence length:
    1189
    Sequence:
    50:
    MVPCWNHGNI | TRSKAEELLS | RTGKDGSFLV | RASESISRAY | ALCVLYRNCV | 
    100:
    YTYRILPNED | DKFTVQASEG | VSMRFFTKLD | QLIEFYKKEN | MGLVTHLQYP | 
    150:
    VPLEEEDTGD | DPEEDTVESV | VSPPELPPRN | IPLTASSCEA | KEVPFSNENP | 
    200:
    RATETSRPSL | SETLFQRLQS | MDTSGLPEEH | LKAIQDYLST | QLAQDSEFVK | 
    250:
    TGSSSLPHLK | KLTTLLCKEL | YGEVIRTLPS | LESLQRLFDQ | QLSPGLRPRP | 
    300:
    QVPGEANPIN | MVSKLSQLTS | LLSSIEDKVK | ALLHEGPESP | HRPSLIPPVT | 
    350:
    FEVKAESLGI | PQKMQLKVDV | ESGKLIIKKS | KDGSEDKFYS | HKKILQLIKS | 
    400:
    QKFLNKLVIL | VETEKEKILR | KEYVFADSKK | REGFCQLLQQ | MKNKHSEQPE | 
    450:
    PDMITIFIGT | WNMGNAPPPK | KITSWFLSKG | QGKTRDDSAD | YIPHDIYVIG | 
    500:
    TQEDPLSEKE | WLEILKHSLQ | EITSVTFKTV | AIHTLWNIRI | VVLAKPEHEN | 
    550:
    RISHICTDNV | KTGIANTLGN | KGAVGVSFMF | NGTSLGFVNS | HLTSGSEKKL | 
    600:
    RRNQNYMNIL | RFLALGDKKL | SPFNITHRFT | HLFWFGDLNY | RVDLPTWEAE | 
    650:
    TIIQKIKQQQ | YADLLSHDQL | LTERREQKVF | LHFEEEEITF | APTYRFERLT | 
    700:
    RDKYAYTKQK | ATGMKYNLPS | WCDRVLWKSY | PLVHVVCQSY | GSTSDIMTSD | 
    750:
    HSPVFATFEA | GVTSQFVSKN | GPGTVDSQGQ | IEFLRCYATL | KTKSQTKFYL | 
    800:
    EFHSSCLESF | VKSQEGENEE | GSEGELVVKF | GETLPKLKPI | ISDPEYLLDQ | 
    850:
    HILISIKSSD | SDESYGEGCI | ALRLEATETQ | LPIYTPLTHH | GELTGHFQGE | 
    900:
    IKLQTSQGKT | REKLYDFVKT | ERDESSGPKT | LKSLTSHDPM | KQWEVTSRAP | 
    950:
    PCSGSSITEI | INPNYMGVGP | FGPPMPLHVK | QTLSPDQQPT | AWSYDQPPKD | 
    1000:
    SPLGPCRGES | PPTPPGQPPI | SPKKFLPSTA | NRGLPPRTQE | SRPSDLGKNA | 
    1050:
    GDTLPQEDLP | LTKPEMFENP | LYGSLSSFPK | PAPRKDQESP | KMPRKEPPPC | 
    1100:
    PEPGILSPSI | VLTKAQEADR | GEGPGKQVPA | PRLRSFTCSS | SAEGRAAGGD | 
    1150:
    KSQGKPKTPV | SSQAPVPAKR | PIKPSRSEIN | QQTPPTPTPR | PPLPVKSPAV | 
    1189:
    LHLQHSKGRD | YRDNTELPHH | GKHRPEEGPP | GPLGRTAMQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    UniGene:
    String:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Cat.:
    E8909m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Cat.:
    E8909r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Cat.:
    E8909h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Cat.:
    U8909h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Cat.:
    U8909m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Cat.:
    U8909r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Cat.:
    P8909Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Cat.:
    P8909Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Monoclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Monoclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Monoclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Protein for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Protein for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
    Protein for Human Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase."
      Drayer A.L. , Pesesse X. , De Smedt F. , Woscholski R. , Parker P. , Erneux C.
      Biochem. Biophys. Res. Commun.225:243-249(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ENZYME ACTIVITY;TISSUE SPECIFICITY;VARIANT TYR-1169
    2. 2.
      "Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation."
      Ware M.D. , Rosten P. , Damen J.E. , Liu L. , Humphries R.K. , Krystal G.
      Blood88:2833-2840(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;INTERACTION WITH SHC1
    3. 3.
      "Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2."
      Kavanaugh W.M. , Pot D.A. , Chin S.M. , Deuter-Reinhard M. , Jefferson A.B. , Norris F.A. , Masiarz F.R. , Cousens L.S. , Majerus P.W. , Williams L.T.
      Curr. Biol.6:438-445(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [MRNA] OF 1-1139 (ISOFORM 1);ENZYME ACTIVITY;INTERACTION WITH GRB2
      tissue: Lung.
    4. 4.
      "The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood."
      Geier S.J. , Algate P.A. , Carlberg K. , Flowers D. , Friedman C. , Trask B. , Rohrschneider L.R.
      Blood89:1876-1885(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    5. 5.
      "Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl."
      Odai H. , Sasaki K. , Iwamatsu A. , Nakamoto T. , Ueno H. , Yamagata T. , Mitani K. , Yazaki Y. , Hirai H.
      Blood89:2745-2756(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;PHOSPHORYLATION;INTERACTION WITH GRB2
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT TYR-1169
      tissue: B-cell.
      tissue: Lymph.
    7. 7.
      "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis."
      Mikhalap S.V. , Shlapatska L.M. , Berdova A.G. , Law C.L. , Clark E.A. , Sidorenko S.P.
      J. Immunol.162:5719-5727(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLAMF1
    8. 8.
      "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells."
      Dunant N.M. , Wisniewski D. , Strife A. , Clarkson B. , Resh M.D.
      Cell. Signal.12:317-326(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH DOK1
    9. 9.
      "Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors."
      Freeburn R.W. , Wright K.L. , Burgess S.J. , Astoul E. , Cantrell D.A. , Ward S.G.
      J. Immunol.169:5441-5450(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-915;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils."
      Vaillancourt M. , Levasseur S. , Tremblay M.-L. , Marois L. , Rollet-Labelle E. , Naccache P.H.
      Cell. Signal.18:2022-2032(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Solution structure of the human SHIP SH2 domain."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2008-04) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-112
    14. 14.
      "Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia."
      Luo J.-M. , Yoshida H. , Komura S. , Ohishi N. , Pan L. , Shigeno K. , Hanamura I. , Miura K. , Iida S. , Ueda R. , Naoe T. , Akao Y. , Ohno R. , Ohnishi K.
      Leukemia17:1-8(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLU-685
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter